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DRUG:

Alunbrig (brigatinib)

i
Other names: AP 26113, AP26113, AP-26113
Company:
Takeda
Drug class:
EGFR inhibitor, ALK inhibitor
Related drugs:
3d
Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2) (clinicaltrials.gov)
P2, N=100, Active, not recruiting, Scott R. Plotkin, MD, PhD | Recruiting --> Active, not recruiting
Enrollment closed • Pan tumor
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NF2 (Neurofibromin 2)
|
Nerlynx (neratinib) • Alunbrig (brigatinib)
22d
Long-Term Response of Lorlatinib to Leptomeningeal Metastasis in Patients with Anaplastic Lymphoma Kinase Fusion Positive Non-Small Lung Cancer: A Case Report. (PubMed, Case Rep Oncol)
In further analysis, lorlatinib revealed superior intracranial efficacy and prolonged time to intracranial progression compared with crizotinib. Herein, we report a case of ALK-positive NSCLC with leptomeningeal metastasis that was successfully treated with lorlatinib after progression to brigatinib and alectinib. This case demonstrates the potential of lorlatinib in managing leptomeningeal metastasis in ALK-positive NSCLC. The case suggests a paradigm shift in therapeutic approaches for CNS metastasis, including brain and leptomeningeal metastases.
Journal
|
ALK (Anaplastic lymphoma kinase)
|
ALK positive • ALK rearrangement • ALK fusion
|
Xalkori (crizotinib) • Alecensa (alectinib) • Lorbrena (lorlatinib) • Alunbrig (brigatinib)
1m
ALK-tyrosine kinase inhibitor intrinsic resistance due to de novo MET-amplification in metastatic ALK-rearranged non-small cell lung cancer effectively treated by alectinib-crizotinib combination-case report. (PubMed, Transl Lung Cancer Res)
A 43-year-old, female diagnosed with T4N3M1c NSCLC harboring the echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion variant 1 (EML4-ALK v.1) and TP53 co-mutation, displayed only mixed response after three months and highly symptomatic progression after 6 months of first-line brigatinib treatment. The latter may represent a mechanism of intrinsic ALK-TKI resistance and its recognition by FISH, in NGS-negative cases, may be considered before initiating first-line treatment. This recognition is clinically important as combined therapy with ALK-TKI and MET-inhibitor should be the preferred first-line treatment.
Journal • Metastases
|
ALK (Anaplastic lymphoma kinase) • TP53 (Tumor protein P53) • MET (MET proto-oncogene, receptor tyrosine kinase) • EML4 (EMAP Like 4)
|
TP53 mutation • MET amplification • ALK rearrangement • MET overexpression • ALK fusion • MET expression
|
Xalkori (crizotinib) • Alecensa (alectinib) • Alunbrig (brigatinib)
1m
Pulmonary Physiology and Systemic Inflammatory in EO Pulmonary Events With Brigatinib Use in NSCLC and Other Diseases (clinicaltrials.gov)
P=N/A, N=18, Active, not recruiting, Academic Thoracic Oncology Medical Investigators Consortium | Trial completion date: Aug 2024 --> Aug 2025
Trial completion date
|
Alunbrig (brigatinib)
1m
NRG-LU003: Targeted Treatment for ALK Positive Patients Who Have Previously Been Treated for Non-squamous Non-small Cell Lung Cancer (clinicaltrials.gov)
P2, N=10, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Sep 2024 --> Sep 2025
Trial completion date
|
MET (MET proto-oncogene, receptor tyrosine kinase)
|
ALK positive • MET amplification • ALK rearrangement
|
cisplatin • Xalkori (crizotinib) • carboplatin • Alecensa (alectinib) • Lorbrena (lorlatinib) • Zykadia (ceritinib) • pemetrexed • Alunbrig (brigatinib) • Ensacove (ensartinib)
1m
IFCT-2101 MASTERPROTOCOL ALK: Study of Safety and Efficacy of Brigatinib Plus Chemotherapy or Brigatinib Only in Advanced ALK-Positive Lung Cancer (MASTERPROTOCOL ALK) (clinicaltrials.gov)
P2, N=110, Active, not recruiting, Intergroupe Francophone de Cancerologie Thoracique | Recruiting --> Active, not recruiting
Enrollment closed • Metastases
|
ALK (Anaplastic lymphoma kinase)
|
ALK rearrangement
|
carboplatin • pemetrexed • Alunbrig (brigatinib)
1m
Cardiovascular toxicity of anaplastic lymphoma kinase inhibitors for patients with non-small cell lung cancer: a network meta-analysis. (PubMed, Future Oncol)
Aim: We conducted network meta-analysis to assess cardiovascular toxicity of anaplastic lymphoma kinase-tyrosine kinase inhibitors (ALK-TKIs).Materials & Eleven articles involving 2855 patients and six interventions including crizotinib, alectinib, ceritinib, lorlatinib, brigatinib and chemotherapy were analyzed. No significant difference was observed in overall cardiovascular risk among ALK-TKIs. For vascular toxicity, crizotinib and ceritinib had a higher risk of thrombotic events than brigatinib. Crizotinib and lorlatinib were more likely to cause blood pressure abnormalities. Clinicians should carefully monitoring cardiovascular events when ALK-TKIs used in NSCLCs patients with baseline cardiovascular diseases.
Retrospective data • Review • Journal
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ALK (Anaplastic lymphoma kinase)
|
Xalkori (crizotinib) • Alecensa (alectinib) • Lorbrena (lorlatinib) • Zykadia (ceritinib) • Alunbrig (brigatinib)
1m
Soluplus-TPGS Mixed Micelles as a Delivery System for Brigatinib: Characterization and In Vitro Evaluation. (PubMed, ACS Omega)
The results of the in vitro stability experiment showed that the selected mixed micelle (F6) was stable at both room temperature and 4 °C, with only minor changes in size and PDI. Our results indicate great potential for the developed Soluplus-TPGS mixed micelles as a delivery system for BGT.
Preclinical • Journal
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ALK (Anaplastic lymphoma kinase)
|
ALK mutation
|
Alunbrig (brigatinib)
1m
Therapeutic effects of an ALK inhibitor, brigatinib, on lung large cell neuroendocrine carcinoma with EML4-ALK fusion. (PubMed, Respir Investig)
Based on the genomic analysis, we treated the patient with brigatinib, an ALK inhibitor. We describe here a patient with LCNEC who responded significantly to brigatinib without serious adverse events.
Journal
|
ALK (Anaplastic lymphoma kinase) • EML4 (EMAP Like 4)
|
ALK rearrangement • EML4-ALK fusion • ALK fusion • EML4-ALK rearrangement
|
Oncomine™ Dx Target Test
|
Alunbrig (brigatinib)
1m
Taiwan Nationwide Study of First-Line ALK-TKI Therapy in ALK-Positive Lung Adenocarcinoma. (PubMed, Target Oncol)
For patients with ALK+ NSCLC, treatments including next-generation ALK-TKIs were independently associated with longer survival outcomes.
Journal
|
ALK (Anaplastic lymphoma kinase)
|
ALK positive • ALK rearrangement
|
Xalkori (crizotinib) • Alecensa (alectinib) • Lorbrena (lorlatinib) • Zykadia (ceritinib) • Alunbrig (brigatinib)
1m
BOUNCE: Brigatinib Post Definitive Chemo-radiotherapy in Patients with ALK-fusion Non-small Cell Lung Cancer (clinicaltrials.gov)
P2, N=0, Withdrawn, ETOP IBCSG Partners Foundation | N=44 --> 0 | Trial completion date: Apr 2029 --> Sep 2024 | Recruiting --> Withdrawn | Trial primary completion date: Apr 2027 --> Sep 2024
Enrollment change • Trial completion date • Trial withdrawal • Trial primary completion date
|
ALK fusion
|
Imfinzi (durvalumab) • Alunbrig (brigatinib)
2ms
Systematic review and network meta-analysis of lorlatinib with comparison to other anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) as first-line treatment for ALK-positive advanced non-smallcell lung cancer (NSCLC). (PubMed, Lung Cancer)
Our NMA analysis adds to existing findings and supplements data gaps from other published NMAs. Findings from eight published NMAs consistently supported lorlatinib as a clinically effective 1L treatment for ALK + advanced NSCLC patients compared to other TKIs.
Retrospective data • Review • Journal • Metastases
|
ALK (Anaplastic lymphoma kinase)
|
ALK positive
|
Xalkori (crizotinib) • Alecensa (alectinib) • Lorbrena (lorlatinib) • Alunbrig (brigatinib)
2ms
Early prediction and impact assessment of CYP3A4-related drug-drug interactions for small molecule anti-cancer drugs using human-CYP3A4-transgenic mouse models. (PubMed, Drug Metab Dispos)
Victim drugs brigatinib and lorlatinib were evaluated with the new approach in combination with the perpetrator drugs itraconazole and rifampicin. The model was able to adequately describe the inhibition of CYP3A4 metabolism and the subsequent magnitude of change in exposure. However, it was unable to accurately predict the magnitude of change in exposure of victim drugs in combination with an inducer.
Preclinical • Journal
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CYP3A4 (Cytochrome P450, family 3, subfamily A, polypeptide 4)
|
Lorbrena (lorlatinib) • Alunbrig (brigatinib) • itraconazole • rifampicin
2ms
Trial completion
|
ALK (Anaplastic lymphoma kinase)
|
ALK rearrangement
|
Alecensa (alectinib) • Zykadia (ceritinib) • Alunbrig (brigatinib)
2ms
Correlation between ALK+ non-small cell lung cancer targeted therapy and thrombosis: a systematic review and network meta-analysis. (PubMed, BMJ Open)
Compared with chemotherapy, alectinib, lorlatinib, brigatinib and ceritinib, crizotinib significantly increased the risk of TE and VTE.
Clinical • Retrospective data • Review • Journal
|
ALK (Anaplastic lymphoma kinase)
|
ALK positive
|
Xalkori (crizotinib) • Alecensa (alectinib) • Lorbrena (lorlatinib) • Zykadia (ceritinib) • Alunbrig (brigatinib)
2ms
Trial completion
|
ALK (Anaplastic lymphoma kinase)
|
ALK positive • ALK rearrangement
|
FoundationOne® CDx • VENTANA ALK (D5F3) CDx Assay
|
Xalkori (crizotinib) • Alecensa (alectinib) • Alunbrig (brigatinib)
2ms
ALK Tyrosine Kinase Inhibitors in ALK-rearranged Advanced Squamous Cell Carcinoma (clinicaltrials.gov)
P2, N=90, Recruiting, Hunan Province Tumor Hospital | Phase classification: P --> P2
Phase classification • Metastases
|
ALK (Anaplastic lymphoma kinase)
|
ALK positive
|
Xalkori (crizotinib) • carboplatin • paclitaxel • Alecensa (alectinib) • Lorbrena (lorlatinib) • pemetrexed • Alunbrig (brigatinib)
2ms
Efficacy of ALK inhibitors in Asian patients with ALK inhibitor-naïve advanced ALK-positive non-small cell lung cancer: a systematic review and network meta-analysis. (PubMed, Transl Lung Cancer Res)
Eight studies, involving 1,477 Asian patients and seven treatments (crizotinib, alectinib, brigatinib, ensartinib, envonalkib, iruplinalkib, and lorlatinib), were included in the NMA. Next-generation ALK inhibitors had better efficacy than crizotinib in the treatment of Asian patients with ALK inhibitor-naïve advanced ALK-positive NSCLC. Iruplinalkib may have more favorable PFS benefit than other ALK inhibitors for Asians.
Retrospective data • Review • Journal • Metastases
|
ALK (Anaplastic lymphoma kinase)
|
ALK positive
|
Xalkori (crizotinib) • Alecensa (alectinib) • Lorbrena (lorlatinib) • Alunbrig (brigatinib) • Ensacove (ensartinib) • Qi Xinke (iruplinalkib) • Anluoqing (envonalkib)
3ms
Comparative Efficacy and Safety of Lorlatinib Versus Alectinib and Lorlatinib Versus Brigatinib for ALK-Positive Advanced/Metastatic NSCLC: Matching-Adjusted Indirect Comparisons. (PubMed, Clin Lung Cancer)
Lorlatinib was estimated to have superior efficacy over first- and second-generation ALK-TKIs, but a higher rate of Grade ≥3 AEs compared to alectinib. These data support the use of lorlatinib as a first-line treatment for ALK+ advanced/metastatic NSCLC.
Journal • Metastases
|
ALK (Anaplastic lymphoma kinase)
|
ALK positive
|
Xalkori (crizotinib) • Alecensa (alectinib) • Lorbrena (lorlatinib) • Alunbrig (brigatinib)
3ms
DELINOR: A Study to Learn About the Effectiveness of Cancer Medicines in Patients With Metastatic Non-small Cell Lung Cancer in Norway. (clinicaltrials.gov)
P=N/A, N=1, Completed, Pfizer | Recruiting --> Completed | N=20605 --> 1 | Trial completion date: Feb 2025 --> Jan 2024 | Trial primary completion date: Feb 2025 --> Jan 2024
Trial completion • Enrollment change • Trial completion date • Trial primary completion date • Metastases
|
Keytruda (pembrolizumab) • Opdivo (nivolumab) • Avastin (bevacizumab) • Xalkori (crizotinib) • Tagrisso (osimertinib) • Tecentriq (atezolizumab) • erlotinib • Gilotrif (afatinib) • carboplatin • gefitinib • Rozlytrek (entrectinib) • paclitaxel • docetaxel • Alecensa (alectinib) • Lorbrena (lorlatinib) • Zykadia (ceritinib) • Alunbrig (brigatinib) • Vizimpro (dacomitinib)
3ms
Real-world treatment sequencing and effectiveness of second- and third-generation ALK tyrosine kinase inhibitors for ALK-positive advanced non-small cell lung cancer. (PubMed, Lung Cancer)
In this large real-world study, TTD2 and the total time on sequential ALK TKIs was approximately 2.5 years. The high attrition rate from 1L to 2L and the longest clinical benefit observed with 1L therapy support using the drug with the longest 1L effectiveness up front in patients with ALK-positive advanced NSCLC.
Journal • HEOR • Real-world evidence • Real-world • Metastases
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ALK (Anaplastic lymphoma kinase)
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Alecensa (alectinib) • Alunbrig (brigatinib)
3ms
Targeting ALK receptors in non-small cell lung cancer: what is the road ahead? (PubMed, Expert Opin Ther Targets)
Second- and third-generation ALK inhibitors (alectinib, brigatinib, and lorlatinib) offer to NSCLC patients a clinically meaningful prolongment of survival with a very good quality of life profile...Very recently, alectinib has been demonstrated to improve efficacy outcomes compared with chemotherapy also in resected stage IB-IIIA ALK-rearranged NSCLC, extending the clinical benefit offered by ALK inhibitors also to the adjuvant setting. Future development of ALK inhibitors in NSCLC treatment includes the search for optimal management of acquired resistance to first-line treatments and the extension of use of ALK inhibitors also to neoadjuvant and preferably to perioperative setting.
Journal
|
ALK (Anaplastic lymphoma kinase)
|
Xalkori (crizotinib) • Alecensa (alectinib) • Lorbrena (lorlatinib) • Alunbrig (brigatinib)
3ms
Trial primary completion date • Metastases
|
ALK (Anaplastic lymphoma kinase)
|
FoundationOne® CDx • VENTANA ALK (D5F3) CDx Assay
|
Xalkori (crizotinib) • Alecensa (alectinib) • Alunbrig (brigatinib)
4ms
EROS: ERectile Dysfunctions, gOnadotoxicity and Sexual Health Assessment in Men With Lung Cancer (clinicaltrials.gov)
P=N/A, N=80, Recruiting, Fondazione Policlinico Universitario Agostino Gemelli IRCCS
New trial
|
Keytruda (pembrolizumab) • Opdivo (nivolumab) • Mekinist (trametinib) • Tagrisso (osimertinib) • Tafinlar (dabrafenib) • carboplatin • paclitaxel • Alecensa (alectinib) • Lorbrena (lorlatinib) • Lumakras (sotorasib) • Retevmo (selpercatinib) • pemetrexed • Alunbrig (brigatinib) • Libtayo (cemiplimab-rwlc)
4ms
Longitudinal Assessment of Genomic Alterations and Clonal Evolution in ALK-positive NSCLC (Galileo Project) (clinicaltrials.gov)
P=N/A, N=108, Recruiting, Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Trial primary completion date: Mar 2024 --> Mar 2026
Trial primary completion date
|
ALK (Anaplastic lymphoma kinase)
|
Alecensa (alectinib) • Lorbrena (lorlatinib) • Alunbrig (brigatinib)
4ms
Case report: Pathological complete response to neoadjuvant brigatinib in stage III non-small cell lung cancer with ALK rearrangement. (PubMed, Front Oncol)
The patient remained disease-free during a 13-month follow-up period. This case report provides compelling evidence of pCR following brigatinib therapy in ALK-positive NSCLC, suggesting that surgery after neoadjuvant therapy with brigatinib may offer a safe and effective approach for patients with ALK-positive NSCLC.
Journal
|
ALK (Anaplastic lymphoma kinase)
|
Alunbrig (brigatinib)
4ms
New P2 trial • Metastases
|
carboplatin • pemetrexed • Alunbrig (brigatinib)
4ms
Intrinsic ALK-TKI Resistance Due to Met-Coamplification in ALK+ NSCLC, Effectively Treated by Alectinib-crizotinib Combination (IASLC-WCLC 2024)
Yet, to our knowledge, we present herein the first case of ALK + NSCLC rapidly progressing on 1 st line Brigatinib treatment due to de novo MET- amplification. The recognition of this mechanism of ALK-TKI resistance by FISH, especially in NGS-negative cases, should be considered before initiating 1 st line treatment. This is of clinical importance, as effective combined therapy with ALK-TKI and MET-inhibitor is feasible.
ALK (Anaplastic lymphoma kinase) • TP53 (Tumor protein P53) • MET (MET proto-oncogene, receptor tyrosine kinase) • EML4 (EMAP Like 4)
|
TP53 mutation • MET amplification • ALK rearrangement • MET overexpression • EML4-ALK fusion • ALK fusion • MET expression • ALK amplification • TP53 G245S
|
Oncomine™ Comprehensive Assay v3M • Archer® FusionPlex® Lung Kit • FusionPlex® Dx
|
Xalkori (crizotinib) • Alecensa (alectinib) • Alunbrig (brigatinib)
4ms
Real-world evidence of brigatinib as second-line treatment after crizotinib for ALK+ non-small cell lung cancer using South Korean claims data (K-AREAL). (PubMed, Cancer Med)
In this first nationwide retrospective study using national insurance claim data, brigatinib demonstrated real-world clinical benefit as second-line treatment after prior crizotinib in ALK+ NSCLC patients in South Korea.
Retrospective data • Journal • HEOR • Real-world evidence • Real-world
|
ALK (Anaplastic lymphoma kinase)
|
Xalkori (crizotinib) • Alunbrig (brigatinib)
4ms
Clinical utility of liquid biopsy for non-small cell lung cancer patients with ALK fusion variants treated with brigatinib (ESMO 2024)
Detection rate by ctDNA profiling is higher compared with RNA-based approaches and it is of prognostic significance.
Clinical • Tumor mutational burden • Liquid biopsy • Biopsy
|
ALK (Anaplastic lymphoma kinase) • TMB (Tumor Mutational Burden) • EML4 (EMAP Like 4)
|
ALK positive • ALK fusion • EML4-ALK variant 1
|
TruSight Oncology 500 Assay • Oncomine Focus Assay • TruSight Oncology 500 ctDNA v2
|
Alunbrig (brigatinib)
4ms
Journal • Real-world evidence • Real-world
|
ALK (Anaplastic lymphoma kinase) • TP53 (Tumor protein P53) • EML4 (EMAP Like 4)
|
Alecensa (alectinib) • Lorbrena (lorlatinib) • Zykadia (ceritinib) • Alunbrig (brigatinib)
4ms
Phase II study of brigatinib in patients with ROS1 fusion-positive non-small-cell lung cancer: the Barossa study. (PubMed, ESMO Open)
Brigatinib was effective in TKI-naive patients with ROS1-rearranged NSCLC. The safety profile of brigatinib was consistent with that reported from previous studies.
P2 data • Journal
|
ALK (Anaplastic lymphoma kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
|
Xalkori (crizotinib) • Alunbrig (brigatinib)
4ms
Survey of Brigatinib Used To Treat People With Non-Small Cell Lung Cancer (clinicaltrials.gov)
P=N/A, N=500, Recruiting, Takeda | Trial completion date: May 2026 --> Nov 2027 | Trial primary completion date: May 2026 --> Nov 2027
Trial completion date • Trial primary completion date
|
ALK (Anaplastic lymphoma kinase)
|
Alunbrig (brigatinib)
4ms
Analysis of the resistance profile of real-world alectinib first-line therapy in patients with ALK rearrangement-positive advanced non-small cell lung cancer using organoid technology in one case of lung cancer. (PubMed, J Thorac Dis)
For one patient who maintained original baseline ALK rearrangement positive without acquired mutation after progression of ceritinib resistance, lung cancer-like organ culture with sequential brigatinib and lorlatinib led to a PFS of 3.2 and 1.9 months, respectively, which aligned with the corresponding drug susceptibility testing results for this patient. NGS testing of patients' blood or tissue samples after disease progression may provide insight into the etiology of alectinib resistance. Patient-sourced drug sensitivity testing of lung cancer-like organs selects drug-sensitive medications based on NGS results and provides a reference for subsequent drug therapy for patients after drug resistance, particularly those who remain ALK rearrangement-positive at baseline.
Journal • Real-world evidence • Real-world • Metastases
|
ALK (Anaplastic lymphoma kinase) • EML4 (EMAP Like 4)
|
Alecensa (alectinib) • Lorbrena (lorlatinib) • Zykadia (ceritinib) • Alunbrig (brigatinib)
5ms
Molecular tumor board: molecularly adjusted therapy upon identification and functional validation of a novel ALK resistance mutation in a case of lung adenocarcinoma. (PubMed, Oncologist)
Our approach demonstrates preclinical, in silico, and clinical evidence of a novel crizotinib resistance mutation in ALK as well as sensitivity toward brigatinib and potentially lorlatinib. In future cases, this procedure represents an important contribution to functional diagnostics in the context of molecular tumor boards.
Journal
|
ALK (Anaplastic lymphoma kinase) • EML4 (EMAP Like 4) • ARG1 (Arginase 1)
|
Xalkori (crizotinib) • Lorbrena (lorlatinib) • Alunbrig (brigatinib)
5ms
Successful intracranial response of lorlatinib after resistance with alectinib and brigatinib in patients with ALK-positive lung adenocarcinoma: Implications of CNS penetration rate of brigatinib. (PubMed, Thorac Cancer)
Taken together, we speculate that the low CNS penetration rate of brigatinib confers CNS progression. Further studies are warranted to reveal the resistance mechanism and propose a treatment strategy for CNS progression in ALK-positive patients.
Journal
|
ALK (Anaplastic lymphoma kinase)
|
Alecensa (alectinib) • Lorbrena (lorlatinib) • Alunbrig (brigatinib)
5ms
Brigatinib in NF2-Related Schwannomatosis with Progressive Tumors. (PubMed, N Engl J Med)
Brigatinib treatment resulted in radiographic responses in multiple tumor types and clinical benefit in a heavily pretreated cohort of patients with NF2-SWN. (Funded by the Children's Tumor Foundation and others; INTUITT-NF2 ClinicalTrials.gov number, NCT04374305.).
Journal
|
NF2 (Neurofibromin 2)
|
Alunbrig (brigatinib)
6ms
ALTA-3: A Study of Brigatinib Compared to Alectinib in Adults With Non-Small-Cell Lung Cancer (clinicaltrials.gov)
P3; Trial completion date: May 2024 --> Sep 2024 | Trial primary completion date: Apr 2024 --> Aug 2024
Trial completion date • Trial primary completion date • Metastases
|
ALK (Anaplastic lymphoma kinase)
|
FoundationOne® CDx • VENTANA ALK (D5F3) CDx Assay
|
Xalkori (crizotinib) • Alecensa (alectinib) • Alunbrig (brigatinib)
6ms
ALK inhibitors in cancer: mechanisms of resistance and therapeutic management strategies. (PubMed, Cancer Drug Resist)
However, the emergence of intrinsic and acquired resistance inevitably occurs with ALK TKI use. This review describes the molecular mechanisms of ALK TKI resistance and discusses management strategies to overcome therapeutic resistance.
Review • Journal
|
ALK (Anaplastic lymphoma kinase)
|
Xalkori (crizotinib) • Alecensa (alectinib) • Lorbrena (lorlatinib) • Zykadia (ceritinib) • Alunbrig (brigatinib)
6ms
PIKACHU: Treatment Strategies and Survival Outcome for Non-small Cell Lung Cancer With Oncogenic Mutation (clinicaltrials.gov)
P2, N=6000, Recruiting, Hunan Province Tumor Hospital | Phase classification: P --> P2 | N=100 --> 6000 | Trial completion date: Dec 2025 --> Dec 2027 | Trial primary completion date: Dec 2024 --> Dec 2026
Phase classification • Enrollment change • Trial completion date • Trial primary completion date
|
EGFR (Epidermal growth factor receptor) • BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
|
cisplatin • Xalkori (crizotinib) • Tagrisso (osimertinib) • erlotinib • gefitinib • Rozlytrek (entrectinib) • Alecensa (alectinib) • Lorbrena (lorlatinib) • Zykadia (ceritinib) • pemetrexed • Alunbrig (brigatinib) • Gavreto (pralsetinib) • Ameile (aumolertinib) • Orpathys (savolitinib) • Ivesa (firmonertinib)
6ms
Cost-Effectiveness Analysis of 6 Tyrosine Kinase Inhibitors as First-Line Treatment for ALK-Positive NSCLC in China. (PubMed, Clin Med Insights Oncol)
This study sought to assess the cost-effectiveness of 6 tyrosine kinase inhibitors (TKIs)-crizotinib, alectinib, ceritinib, brigatinib, ensartinib, and lorlatinib-as first-line treatments for ALK-positive NSCLC from the perspective of the Chinese health care system. Under a willingness-to-pay threshold of $38 223/QALY, ceritinib and brigatinib were cost-effective compared with ensartinib, while lorlatinib and alectinib were not cost-effective when compared with ensartinib. Overall, brigatinib emerged as the most cost-effective treatment among all the options considered.
Journal • HEOR • Cost-effectiveness • Cost effectiveness
|
ALK (Anaplastic lymphoma kinase)
|
Xalkori (crizotinib) • Alecensa (alectinib) • Lorbrena (lorlatinib) • Zykadia (ceritinib) • Alunbrig (brigatinib) • Ensacove (ensartinib)