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BIOMARKER:

TMB-H + ALK rearrangement

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Entrez ID:

Related biomarkers:

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MSI-H/dMMR + TMB-H (8)

TMB-H + PD-L1 overexpression (7)

EML4-ALK variant 3 + TP53 mutation (5)

MSI-H/dMMR + TMB-L (5)

ALK fusion + ALK G1202R (4)

TP53 mutation + ALK positive (4)

ALK rearrangement + MET amplification (3)

EGFR wild-type + ALK wild-type + PD-L1 expression (3)

EML4-ALK fusion + ALK F1174L + ALK S1189C (3)

EML4-ALK fusion + ALK positive (3)

PPFIBP1-ALK translocation + ALK G1202R + ALK V1180L (3)

RANBP2-ALK rearrangement + TNFRSF8 expression (3)

BRCA1 mutation + TMB-H (3)

KMT2D mutation + TMB-H (3)

MLL3 mutation + TMB-H (3)

MSI-H/dMMR + TMB-H + PD-L1 negative (3)

PD-L1 expression + TMB-H (3)

ALK fusion + TP53 mutation (2)

ALK positive + ALK mutation (2)

ALK rearrangement + PD-L1 overepxression (2)

EML4-ALK + ALK G1202R + LIPI-NTRK1 (2)

EML4-ALK fusion + ALK G1202R (2)

EML4-ALK fusion + ALK rearrangement (2)

EML4-ALK fusion + TP53 mutation (2)

EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)

MYC amplification + ALK F1174L (2)

MYCN amplification + ALK F1174V (2)

MYCN amplification + ALK rearrangement (2)

STRN-ALK fusion + MET amplification (2)

EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)

HER-2 expression + TMB-H (2)

LRP1B mutation + TMB-H (2)

MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)

NCOR2-NTRK1 fusion + TMB-H (2)

PAPPA2 mutation + TMB-H (2)

PD-L1 expression + TMB-H + FANCA deletion (2)

STK11 mutation + TMB-H (2)

TMB-H + EGFR exon 19 deletion (2)

TMB-H + EGFR mutation (2)

TMB-H + HER-2 positive (2)

TMB-H + PD-L1 negative (2)

TMB-H + PD-L1 underexpression (2)

TMB-H + PIK3CA mutation (2)

TMB-L + BAP1 V99M + NF2 R34 + Chr del(14q) + Chr del(19q) (2)

TMB-L + PD-L1 expression (2)

ALK exon 23 C1156Y missense mutation+ LOC101927285-ALK fusion (1)

ALK expression + RSRC1-ALK fusion (1)

ALK fusion + ALK G1269A (1)

ALK fusion + ALK I1179T (1)

ALK fusion + ALK V1180L (1)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)

ALK fusion + FAT3 mutation (1)

ALK fusion + FAT4 mutation (1)

ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)

ALK mutation + TMB-H (1)

ALK negative + S100A8 elevation (1)

ALK negative + S100A9 elevation (1)

ALK negative + SAA1 elevation (1)

ALK negative + SAA2 elevation (1)

ALK negative + TP53 deletion (1)

ALK positive + ALK G1202R (1)

ALK positive + ALK G1202R + ALK L1196M (1)

ALK positive + ALK L1196M + ALK D1203N (1)

ALK positive + DNMT3A N403Tfs* (1)

ALK positive + EML4-ALK fusion + TP53 mutation (1)

ALK positive + ERCC3 E259D + GNAS A436_P459del (1)

ALK positive + MYC amplification + CCND1 deletion (1)

ALK psoitive + ALK G1202R + ALK F1174C (1)

ALK rearrangement + ABCC11 overexpression (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

ALK rearrangement + BRCA2 F2801fs (1)

ALK rearrangement + CDKN2A deletion (1)

ALK rearrangement + CDKN2B deletion (1)

ALK rearrangement + CTLA4 overexpression (1)

ALK rearrangement + EML4-ALK fusion + CCDC148-ALK fusion + PKDCC-ALK fusion + VIT-ALK fusion (1)

ALK rearrangement + MET amplification (1)

ALK wild-type + NT5E overexpression + PD-L1 expression (1)

ALK-EML4_V3a + PD-L1 overexpression (1)

ALK-EML4_V3b + PD-L1 overexpression (1)

BCL2L11 deletion + ALK positive (1)

CPE-ALK fusion + TP53 wild-type (1)

EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)

EGFR exon 19 deletion + STRN-ALK fusion (1)

EGFR mutation + ALK negative + TMB-H (1)

EGFR negative + ALK negative + PD-L1 expression (1)

EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)

EML4-ALK fusion + ALK I1171N (1)

EML4-ALK fusion + ALK I1171T (1)

EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification (1)

EML4-ALK fusion + TMB-L (1)

EML4-ALK fusion v1insLTBP1 (1)

IDH2 mutation + ALK fusion (1)

KIF5B-ALK fusion + ALK L1196M (1)

MET amplification + KLC1-ALK fusion (1)

MET exon 14 mutation + ALK wild-type (1)

MYCN amplification + ALK F1174L (1)

MYCN amplification + ALK R1275Q (1)

PIK3CA mutation + ALK fusion (1)

PIK3CA mutation + ALK positive (1)

PTEN mutation + ALK positive (1)

SLC8A1-PKDCC-ALK fusion + ALK overexpression (1)

SMARCA4 mutation + ALK positive (1)

STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)

STRN-ALK fusion + KRAS G13D (1)

TPM3-NTRK1 fusion + ALK L1196M (1)

AHNAK2 mutation + TMB-H (1)

ARID1A mutation + TMB-H (1)

ARID1B mutation + TMB-H (1)

ASPSCR1-TFE3 fusion +TMB-H (1)

BAP1 deletion + TMB-L + PD-L1 expression (1)

BRAF mutation + TMB-H (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

BRCA1 mutation + BRCA2 mutation + TMB-H (1)

BRCA2 mutation + TMB-H (1)

BRCA2 mutation + TMB-L (1)

CD20 positive + TMB-L (1)

CD74-ROS1 fusion + TMB-H (1)

CDKN2A mutation + TMB-H (1)

EGFR L858R + TMB-H (1)

EGFR T790M + TMB-H (1)

ELF3 mutation + TMB-L + MSI-L/dMMR (1)

ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)

ERBB3 R135C + TMB-H (1)

HER-2 elevation + TMB-H (1)

HER-2 elevation + TMB-L (1)

HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)

HER-2 mutation + TMB-H (1)

HLA-E overexpression + TMB-L (1)

HR positive + TMB-H (1)

HR positive + TMB-L (1)

High IFNG gene signature + TMB-H (1)

IDH1 mutation + TMB-L (1)

IDH2 mutation + TMB-L (1)

KEAP1 mutation + TMB-H + PD-L1 overexpression (1)

KMT2C mutation + BCOR mutation + KDM5C mutation + TMB-H (1)

KMT2C mutation + TMB-H (1)

KRAS A146 + TMB-H (1)

KRAS G12D + HER-2 amplification + TMB-H (1)

MAP2K1 mutation + TMB-H (1)

MAP2K2 mutation + TMB-H (1)

MET mutation + TMB-H (1)

MGA mutation + TMB-L (1)

MGAM mutation + TMB-H (1)

MLH1 methylation + MSI-H/dMMR + TMB-H (1)

MSI-H/dMMR + TMB-H + POLE mutation (1)

NCR3LG1 underexpression + TMB-L (1)

NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)

NPAP1 mutation + TMB-H (1)

NTRK3 mutation + TMB-H (1)

PBRM1 mutation + TMB-H (1)

PBRM1 mutation + TMB-L + MSI-L/dMMR (1)

PD-L1 amplification + PD-L2 amplification + TMB-H (1)

PD-L1 negative + TMB-L (1)

PD-L1 negative + TMB-L + STING overexpression (1)

PD-L1 overexpression + TMB-H (1)

PD-L1 overexpression + TMB-H + ARID1A F2141fs*59 (1)

PD-L1 overexpression + TMB-L (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

POLE E790Q + ERBB2 amplification + TMB-H (1)

POLE P286R + TMB-H (1)

POLE V1368M + ERBB3 G1271S + TNFAIP3 P714A + PRKN I69T + TSC2 G1399R + TMB-L (1)

POLE mutation + PD-L1 negative + TMB-H (1)

PTCH1 1504-1G>T + TMB-H (1)

PTPN11 mutation + TMB-H (1)

PTPRD mutation + TMB-H (1)

RECQL5 mutation + TMB-H (1)

RET amplification + TMB-H + PD-L1 expression (1)

RYR1 mutation + TMB-H (1)

SMARCA4 mutation + TMB-H (1)

SMARCB1 mutation + TMB-H (1)

STK11 deletion + TMB-H (1)

STK11 mutation + TMB-H + PD-L1 overexpression (1)

TMB-H + CDKN2B mutation (1)

TMB-H + DDR (1)

TMB-H + KDM6A mutation (1)

TMB-H + LDH elevation (1)

TMB-H + MLL2 mutation (1)

TMB-H + MSH6 F1088fs (1)

TMB-H + PD-L1 expression + MSI-L/dMMR (1)

TMB-H + RB1 mutation + PD-L1 underexpression (1)

TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)

TMB-H + TERT promoter mutation (1)

TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23 (1)

TMB-L + LDH elevation (1)

TMB-L + PD-L1 underexpression (1)

TMB-L + RB1 mutation (1)

TP53 S12F + KRAS G12D + TMB-L (1)

TP53 mutation + FANCM mutation + TMB-H (1)

TP53 mutation + LRP1B mutation + TMB-H (1)

TP53 mutation + TMB-H + PD-L1 overexpression (1)

TPR mutation + TMB-H (1)

TTF1 expression + NAPSA expression + PD-L1 expression + TMB-H (1)

XIRP2 mutation + TMB-H (1)

ZNF479 mutation + TMB-H (1)

PD-L1 underexpression + ALK wild-type (0)

HR positive + HER-2 negative + TMB-L (0)

NOTCH4 mutation + PD-L1 expression + TMB-H (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

MSI-H/dMMR + TMB-H (8)

TMB-H + PD-L1 overexpression (7)

EML4-ALK variant 3 + TP53 mutation (5)

MSI-H/dMMR + TMB-L (5)

ALK fusion + ALK G1202R (4)

TP53 mutation + ALK positive (4)

ALK rearrangement + MET amplification (3)

EGFR wild-type + ALK wild-type + PD-L1 expression (3)

EML4-ALK fusion + ALK F1174L + ALK S1189C (3)

EML4-ALK fusion + ALK positive (3)

PPFIBP1-ALK translocation + ALK G1202R + ALK V1180L (3)

RANBP2-ALK rearrangement + TNFRSF8 expression (3)

BRCA1 mutation + TMB-H (3)

KMT2D mutation + TMB-H (3)

MLL3 mutation + TMB-H (3)

MSI-H/dMMR + TMB-H + PD-L1 negative (3)

PD-L1 expression + TMB-H (3)

ALK fusion + TP53 mutation (2)

ALK positive + ALK mutation (2)

ALK rearrangement + PD-L1 overepxression (2)

EML4-ALK + ALK G1202R + LIPI-NTRK1 (2)

EML4-ALK fusion + ALK G1202R (2)

EML4-ALK fusion + ALK rearrangement (2)

EML4-ALK fusion + TP53 mutation (2)

EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)

MYC amplification + ALK F1174L (2)

MYCN amplification + ALK F1174V (2)

MYCN amplification + ALK rearrangement (2)

STRN-ALK fusion + MET amplification (2)

EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)

HER-2 expression + TMB-H (2)

LRP1B mutation + TMB-H (2)

MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)

NCOR2-NTRK1 fusion + TMB-H (2)

PAPPA2 mutation + TMB-H (2)

PD-L1 expression + TMB-H + FANCA deletion (2)

STK11 mutation + TMB-H (2)

TMB-H + EGFR exon 19 deletion (2)

TMB-H + EGFR mutation (2)

TMB-H + HER-2 positive (2)

TMB-H + PD-L1 negative (2)

TMB-H + PD-L1 underexpression (2)

TMB-H + PIK3CA mutation (2)

TMB-L + BAP1 V99M + NF2 R34 + Chr del(14q) + Chr del(19q) (2)

TMB-L + PD-L1 expression (2)

ALK exon 23 C1156Y missense mutation+ LOC101927285-ALK fusion (1)

ALK expression + RSRC1-ALK fusion (1)

ALK fusion + ALK G1269A (1)

ALK fusion + ALK I1179T (1)

ALK fusion + ALK V1180L (1)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)

ALK fusion + FAT3 mutation (1)

ALK fusion + FAT4 mutation (1)

ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)

ALK mutation + TMB-H (1)

ALK negative + S100A8 elevation (1)

ALK negative + S100A9 elevation (1)

ALK negative + SAA1 elevation (1)

ALK negative + SAA2 elevation (1)

ALK negative + TP53 deletion (1)

ALK positive + ALK G1202R (1)

ALK positive + ALK G1202R + ALK L1196M (1)

ALK positive + ALK L1196M + ALK D1203N (1)

ALK positive + DNMT3A N403Tfs* (1)

ALK positive + EML4-ALK fusion + TP53 mutation (1)

ALK positive + ERCC3 E259D + GNAS A436_P459del (1)

ALK positive + MYC amplification + CCND1 deletion (1)

ALK psoitive + ALK G1202R + ALK F1174C (1)

ALK rearrangement + ABCC11 overexpression (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

ALK rearrangement + BRCA2 F2801fs (1)

ALK rearrangement + CDKN2A deletion (1)

ALK rearrangement + CDKN2B deletion (1)

ALK rearrangement + CTLA4 overexpression (1)

ALK rearrangement + EML4-ALK fusion + CCDC148-ALK fusion + PKDCC-ALK fusion + VIT-ALK fusion (1)

ALK rearrangement + MET amplification (1)

ALK wild-type + NT5E overexpression + PD-L1 expression (1)

ALK-EML4_V3a + PD-L1 overexpression (1)

ALK-EML4_V3b + PD-L1 overexpression (1)

BCL2L11 deletion + ALK positive (1)

CPE-ALK fusion + TP53 wild-type (1)

EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)

EGFR exon 19 deletion + STRN-ALK fusion (1)

EGFR mutation + ALK negative + TMB-H (1)

EGFR negative + ALK negative + PD-L1 expression (1)

EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)

EML4-ALK fusion + ALK I1171N (1)

EML4-ALK fusion + ALK I1171T (1)

EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification (1)

EML4-ALK fusion + TMB-L (1)

EML4-ALK fusion v1insLTBP1 (1)

IDH2 mutation + ALK fusion (1)

KIF5B-ALK fusion + ALK L1196M (1)

MET amplification + KLC1-ALK fusion (1)

MET exon 14 mutation + ALK wild-type (1)

MYCN amplification + ALK F1174L (1)

MYCN amplification + ALK R1275Q (1)

PIK3CA mutation + ALK fusion (1)

PIK3CA mutation + ALK positive (1)

PTEN mutation + ALK positive (1)

SLC8A1-PKDCC-ALK fusion + ALK overexpression (1)

SMARCA4 mutation + ALK positive (1)

STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)

STRN-ALK fusion + KRAS G13D (1)

TPM3-NTRK1 fusion + ALK L1196M (1)

AHNAK2 mutation + TMB-H (1)

ARID1A mutation + TMB-H (1)

ARID1B mutation + TMB-H (1)

ASPSCR1-TFE3 fusion +TMB-H (1)

BAP1 deletion + TMB-L + PD-L1 expression (1)

BRAF mutation + TMB-H (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

BRCA1 mutation + BRCA2 mutation + TMB-H (1)

BRCA2 mutation + TMB-H (1)

BRCA2 mutation + TMB-L (1)

CD20 positive + TMB-L (1)

CD74-ROS1 fusion + TMB-H (1)

CDKN2A mutation + TMB-H (1)

EGFR L858R + TMB-H (1)

EGFR T790M + TMB-H (1)

ELF3 mutation + TMB-L + MSI-L/dMMR (1)

ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)

ERBB3 R135C + TMB-H (1)

HER-2 elevation + TMB-H (1)

HER-2 elevation + TMB-L (1)

HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)

HER-2 mutation + TMB-H (1)

HLA-E overexpression + TMB-L (1)

HR positive + TMB-H (1)

HR positive + TMB-L (1)

High IFNG gene signature + TMB-H (1)

IDH1 mutation + TMB-L (1)

IDH2 mutation + TMB-L (1)

KEAP1 mutation + TMB-H + PD-L1 overexpression (1)

KMT2C mutation + BCOR mutation + KDM5C mutation + TMB-H (1)

KMT2C mutation + TMB-H (1)

KRAS A146 + TMB-H (1)

KRAS G12D + HER-2 amplification + TMB-H (1)

MAP2K1 mutation + TMB-H (1)

MAP2K2 mutation + TMB-H (1)

MET mutation + TMB-H (1)

MGA mutation + TMB-L (1)

MGAM mutation + TMB-H (1)

MLH1 methylation + MSI-H/dMMR + TMB-H (1)

MSI-H/dMMR + TMB-H + POLE mutation (1)

NCR3LG1 underexpression + TMB-L (1)

NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)

NPAP1 mutation + TMB-H (1)

NTRK3 mutation + TMB-H (1)

PBRM1 mutation + TMB-H (1)

PBRM1 mutation + TMB-L + MSI-L/dMMR (1)

PD-L1 amplification + PD-L2 amplification + TMB-H (1)

PD-L1 negative + TMB-L (1)

PD-L1 negative + TMB-L + STING overexpression (1)

PD-L1 overexpression + TMB-H (1)

PD-L1 overexpression + TMB-H + ARID1A F2141fs*59 (1)

PD-L1 overexpression + TMB-L (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

POLE E790Q + ERBB2 amplification + TMB-H (1)

POLE P286R + TMB-H (1)

POLE V1368M + ERBB3 G1271S + TNFAIP3 P714A + PRKN I69T + TSC2 G1399R + TMB-L (1)

POLE mutation + PD-L1 negative + TMB-H (1)

PTCH1 1504-1G>T + TMB-H (1)

PTPN11 mutation + TMB-H (1)

PTPRD mutation + TMB-H (1)

RECQL5 mutation + TMB-H (1)

RET amplification + TMB-H + PD-L1 expression (1)

RYR1 mutation + TMB-H (1)

SMARCA4 mutation + TMB-H (1)

SMARCB1 mutation + TMB-H (1)

STK11 deletion + TMB-H (1)

STK11 mutation + TMB-H + PD-L1 overexpression (1)

TMB-H + CDKN2B mutation (1)

TMB-H + DDR (1)

TMB-H + KDM6A mutation (1)

TMB-H + LDH elevation (1)

TMB-H + MLL2 mutation (1)

TMB-H + MSH6 F1088fs (1)

TMB-H + PD-L1 expression + MSI-L/dMMR (1)

TMB-H + RB1 mutation + PD-L1 underexpression (1)

TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)

TMB-H + TERT promoter mutation (1)

TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23 (1)

TMB-L + LDH elevation (1)

TMB-L + PD-L1 underexpression (1)

TMB-L + RB1 mutation (1)

TP53 S12F + KRAS G12D + TMB-L (1)

TP53 mutation + FANCM mutation + TMB-H (1)

TP53 mutation + LRP1B mutation + TMB-H (1)

TP53 mutation + TMB-H + PD-L1 overexpression (1)

TPR mutation + TMB-H (1)

TTF1 expression + NAPSA expression + PD-L1 expression + TMB-H (1)

XIRP2 mutation + TMB-H (1)

ZNF479 mutation + TMB-H (1)

PD-L1 underexpression + ALK wild-type (0)

HR positive + HER-2 negative + TMB-L (0)

NOTCH4 mutation + PD-L1 expression + TMB-H (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

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TMB-H + ALK rearrangement

Non Small Cell Lung Cancer

Resistant: C3 – Early Trials

Resistant: C3 – Early Trials