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Association details:
| Biomarker: | PIK3CA mutation + TTN mutation + IDH2 mutation |
|---|---|
| Cancer: | Glioma |
| Drug: | Temodex (temozolomide gel) (DNA synthesis inhibitor, Alkylating agent) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Molecular subtype specific biomarkers improve prediction of temozolomide therapy in low grade glioma
Excerpt:
...the combination of PIK3CA with TTN mutations (marked as PIK3CA/TTN) exhibited striking correlation with PFS (p < 0.01) and OS (p < 0.01) in the IDHmut cohort (IDHmut-codel and IDHmut-non-codel cohorts), and multivariate cox regression confirmed it was also an independent predictor of PFS (p < 0.01) and OS (p < 0.01). OS was significantly higher in PIK3CA/TTN patients (p = 0.04) and multivariate cox regression confirmed its independent predictive effect (p=0.04).
