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BIOMARKER:
POLE E790Q + ERBB2 amplification + TMB-H
i
Other names:
POLE1, DNA Polymerase Epsilon Catalytic Subunit, DNA Polymerase Epsilon Catalytic Subunit A, Polymerase (DNA) Epsilon Catalytic Subunit, DNA Polymerase II Subunit A, Polymerase (DNA Directed) Epsilon Catalytic Subunit, DNA Polymerase Epsilon Catalytic Subunit Protein, Polymerase (DNA Directed) Epsilon, ERBB2, CD340, HER-2, HER2, NEU, NGL, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2, TMB | Tumor Mutational Burden
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Entrez ID:
2064
;
5426
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
HER-2 mutation (89)
HER-2 exon 20 insertion (27)
POLE mutation (27)
HER-2 L755S (26)
HER-2 A775_G776insYVMA (10)
HER-2 S310F (10)
HER-2 V777L (10)
HER-2 L755P (7)
HER-2 S310Y (6)
HER-2 G778_P780dup (5)
HER-2 L768S (4)
HER-2 Y772_A775dup (4)
HER-2 exon 20 mutation (4)
HER-2 C634R (3)
HER-2 D769Y (3)
HER-2 I655V (3)
HER-2 K753E (3)
HER-2 L869R (3)
HER-2 V777L + EGFR L858R (3)
HER-2 V842I (3)
POLE V411L (3)
HER-2 G776insV_C (2)
HER-2 G776insV_G (2)
HER-2 G778_S779insCPG (2)
HER-2 G780_P781dupGSP (2)
HER-2 H878Y (2)
HER-2 L755_T759del (2)
HER-2 L866M (2)
HER-2 T798M (2)
HER-2 T862A + HER-2 L755S (2)
HER-2 V773A (2)
HER-2 V773L (2)
HER-2 V777L + PIK3CA H1047R (2)
HER-2 exon 20 YVMA insertion (2)
HER-2 exon 20G776>VC insertion (2)
POLE P286R (2)
ALK rearrangement + HER-2 mutation (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR T790M + HER-2 mutation (1)
ERBB3 mutation + HER-2 mutation (1)
HER-2 1899‐1G>A (1)
HER-2 755_759del (1)
HER-2 778insGSP (1)
HER-2 A1170P (1)
HER-2 A775 (1)
HER-2 D769H (1)
HER-2 E395K (1)
HER-2 G309A (1)
HER-2 G660D + HER-2 S310F (1)
HER-2 G766V (1)
HER-2 G776L (1)
HER-2 G776S (1)
HER-2 K676R (1)
HER-2 L726I (1)
HER-2 M774delinsWLV (1)
HER-2 N857S (1)
HER-2 P780-Y781insGSP (1)
HER-2 P780ins (1)
HER-2 Q57R (1)
HER-2 Q680R (1)
HER-2 R647K (1)
HER-2 R678Q (1)
HER-2 R784G (1)
HER-2 R896C (1)
HER-2 R896G (1)
HER-2 S335C (1)
HER-2 T798I (1)
HER-2 T862A (1)
HER-2 V658E (1)
HER-2 V659D (1)
HER-2 YVMA (1)
HER-2 exon 17 mutation (1)
HER-2 exon 19 mutation (1)
HER-2 exon 20 G776delinsVC (1)
HER-2 exon 23 mutation (1)
HER-2 mutation + CDK6 mutation (1)
HER-2 mutation + HER-2 T798I (1)
HER-2 mutation + TP53 wild-type (1)
HER-2 rearrangement (1)
p95HER2 mutation (1)
POLE A456P (1)
POLE EDM (1)
POLE mutation + POLD1 mutation (1)
HER-2 negative + HR positive + PTEN mutation (0)
HER-2 negative + ER positive + ESR1 mutation (0)
HER-2 negative + HR negative + BRCA mutation (0)
HER-2 negative + HR positive + AKT1 mutation (0)
HER-2 negative + HR positive + BRCA mutation (0)
HER-2 negative + HR positive + ESR1 mutation (0)
HER-2 negative + HR positive + ESR1 mutation + PIK3CA mutation (0)
HER-2 negative + HR positive + ESR1 wild-type (0)
HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)
HER-2 negative + HR positive + PIK3CA mutation (0)
HER2 L726I (0)
POLE S459F (0)
HER-2 mutation (89)
HER-2 exon 20 insertion (27)
POLE mutation (27)
HER-2 L755S (26)
HER-2 A775_G776insYVMA (10)
HER-2 S310F (10)
HER-2 V777L (10)
HER-2 L755P (7)
HER-2 S310Y (6)
HER-2 G778_P780dup (5)
HER-2 L768S (4)
HER-2 Y772_A775dup (4)
HER-2 exon 20 mutation (4)
HER-2 C634R (3)
HER-2 D769Y (3)
HER-2 I655V (3)
HER-2 K753E (3)
HER-2 L869R (3)
HER-2 V777L + EGFR L858R (3)
HER-2 V842I (3)
POLE V411L (3)
HER-2 G776insV_C (2)
HER-2 G776insV_G (2)
HER-2 G778_S779insCPG (2)
HER-2 G780_P781dupGSP (2)
HER-2 H878Y (2)
HER-2 L755_T759del (2)
HER-2 L866M (2)
HER-2 T798M (2)
HER-2 T862A + HER-2 L755S (2)
HER-2 V773A (2)
HER-2 V773L (2)
HER-2 V777L + PIK3CA H1047R (2)
HER-2 exon 20 YVMA insertion (2)
HER-2 exon 20G776>VC insertion (2)
POLE P286R (2)
ALK rearrangement + HER-2 mutation (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR T790M + HER-2 mutation (1)
ERBB3 mutation + HER-2 mutation (1)
HER-2 1899‐1G>A (1)
HER-2 755_759del (1)
HER-2 778insGSP (1)
HER-2 A1170P (1)
HER-2 A775 (1)
HER-2 D769H (1)
HER-2 E395K (1)
HER-2 G309A (1)
HER-2 G660D + HER-2 S310F (1)
HER-2 G766V (1)
HER-2 G776L (1)
HER-2 G776S (1)
HER-2 K676R (1)
HER-2 L726I (1)
HER-2 M774delinsWLV (1)
HER-2 N857S (1)
HER-2 P780-Y781insGSP (1)
HER-2 P780ins (1)
HER-2 Q57R (1)
HER-2 Q680R (1)
HER-2 R647K (1)
HER-2 R678Q (1)
HER-2 R784G (1)
HER-2 R896C (1)
HER-2 R896G (1)
HER-2 S335C (1)
HER-2 T798I (1)
HER-2 T862A (1)
HER-2 V658E (1)
HER-2 V659D (1)
HER-2 YVMA (1)
HER-2 exon 17 mutation (1)
HER-2 exon 19 mutation (1)
HER-2 exon 20 G776delinsVC (1)
HER-2 exon 23 mutation (1)
HER-2 mutation + CDK6 mutation (1)
HER-2 mutation + HER-2 T798I (1)
HER-2 mutation + TP53 wild-type (1)
HER-2 rearrangement (1)
p95HER2 mutation (1)
POLE A456P (1)
POLE EDM (1)
POLE mutation + POLD1 mutation (1)
HER-2 negative + HR positive + PTEN mutation (0)
HER-2 negative + ER positive + ESR1 mutation (0)
HER-2 negative + HR negative + BRCA mutation (0)
HER-2 negative + HR positive + AKT1 mutation (0)
HER-2 negative + HR positive + BRCA mutation (0)
HER-2 negative + HR positive + ESR1 mutation (0)
HER-2 negative + HR positive + ESR1 mutation + PIK3CA mutation (0)
HER-2 negative + HR positive + ESR1 wild-type (0)
HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)
HER-2 negative + HR positive + PIK3CA mutation (0)
HER2 L726I (0)
POLE S459F (0)
›
Associations
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VERI cancer hierarchy
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POLE E790Q + ERBB2 amplification + TMB-H
HER2 Positive Breast Cancer
POLE E790Q + ERBB2 amplification + TMB-H
HER2 Positive Breast Cancer
pembrolizumab + trastuzumab
Sensitive: C4 – Case Studies
pembrolizumab + trastuzumab
Sensitive
:
C4
pembrolizumab + trastuzumab
Sensitive: C4 – Case Studies
pembrolizumab + trastuzumab
Sensitive
:
C4
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