Login
Evidence Feed
About
Diagnostics
New
Top genes
FAQ
Contact us
^
Login
Contact us
to learn more about
our Premium Content: News alerts, weekly reports and conference planners
BIOMARKER:
POLE E790Q + ERBB2 amplification + TMB-H
i
Other names:
POLE1, DNA Polymerase Epsilon Catalytic Subunit, DNA Polymerase Epsilon Catalytic Subunit A, Polymerase (DNA) Epsilon Catalytic Subunit, DNA Polymerase II Subunit A, Polymerase (DNA Directed) Epsilon Catalytic Subunit, DNA Polymerase Epsilon Catalytic Subunit Protein, Polymerase (DNA Directed) Epsilon, ERBB2, CD340, HER-2, HER2, NEU, NGL, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2, TMB | Tumor Mutational Burden
Contact us
to learn more about our Premium Content:
News alerts, weekly reports and conference planners
Entrez ID:
2064
;
5426
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
TMB-H (186)
TMB-L (25)
HER-2 amplification + RAS wild-type + BRAF wild-type (9)
MSI-H/dMMR + TMB-H (8)
TMB-H + PD-L1 overexpression (7)
MSI-H/dMMR + TMB-L (5)
HER-2 positive + HER-2 amplification (4)
RAS wild-type + HER-2 positive (4)
MSI-H/dMMR + POLE mutation (4)
HER-2 amplification + KRAS G12D (3)
BRCA1 mutation + TMB-H (3)
KMT2D mutation + TMB-H (3)
MLL3 mutation + TMB-H (3)
MSI-H/dMMR + TMB-H + PD-L1 negative (3)
PD-L1 expression + TMB-H (3)
BRAF wild-type + HER-2 positive (2)
BRCA1 mutation + HER-2 negative (2)
BRCA2 mutation + HER-2 negative (2)
HER-2 S310F + HER-2 amplification (2)
HER-2 amplification + EGFR-ZNF880 fusion + EGFR E114K (2)
HER-2 amplification + HER-2 L755S (2)
HER-2 amplification + PD-L1 expression (2)
HER-2 amplification + RAS wild-type (2)
HER-2 expression + HER-2 D769H (2)
HER-2 expression + HER-2 L869R (2)
HER-2 expression + HER-2 amplification (2)
HER-2 expression + TMB-H (2)
RAS wild-type + BRAF wild-type + HER-2 positive (2)
TMB-H + HER-2 positive (2)
EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)
LRP1B mutation + TMB-H (2)
MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)
NCOR2-NTRK1 fusion + TMB-H (2)
PAPPA2 mutation + TMB-H (2)
PD-L1 expression + TMB-H + FANCA deletion (2)
STK11 mutation + TMB-H (2)
TMB-H + EGFR exon 19 deletion (2)
TMB-H + EGFR mutation (2)
TMB-H + PD-L1 negative (2)
TMB-H + PD-L1 underexpression (2)
TMB-H + PIK3CA mutation (2)
TMB-L + BAP1 V99M + NF2 R34 + Chr del(14q) + Chr del(19q) (2)
TMB-L + PD-L1 expression (2)
AR positive + HER-2 amplification (1)
BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)
CD74-NRG1 fusion + EGFR mutation + HER-2 mutation (1)
EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)
EGFR T790M + HER-2 amplification (1)
EGFR exon 19 deletion + EGFR T790M + EGFR C797S + HER-2 amplification (1)
ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)
ER positive + HER-2 D769H + HER-2 V777L (1)
ERBB2 G778A + CCNE1 amplification (1)
ERBB3 mutation + HER-2 amplification (1)
ERBB4 mutation + HER-2 positive (1)
HER-2 amplification + AXL expression (1)
HER-2 amplification + BRAF wild-type (1)
HER-2 amplification + CCNE1 expression (1)
HER-2 amplification + EGFR mutation (1)
HER-2 amplification + ER positive + PGR negative (1)
HER-2 amplification + HER-2 R157W (1)
HER-2 amplification + HER-2 mutation (1)
HER-2 amplification + KRAS exon 2 wild-type (1)
HER-2 amplification + KRAS wild-type (1)
HER-2 elevation (1)
HER-2 elevation + TMB-H (1)
HER-2 elevation + TMB-L (1)
HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)
HER-2 mutation + HER-2 positive (1)
HER-2 mutation + TMB-H (1)
HER-2 overexpression + CCNE1 amplification (1)
HER-2 overexpression + HER-2 amplification (1)
HER-2 overexpression + KRAS G12C (1)
HER-2 overexpression + KRAS wild-type (1)
HER-2 overexpression + PTEN deletion (1)
HER-2 overexpression + RAS wild-type (1)
HER-2 positive + APC mutation (1)
HER-2 positive + GATA6 amplification (1)
HER-2 positive + MYC amplification (1)
HER-2 positive + TP53 mutation (1)
HER-2 underexpression + CCNE1 amplification (1)
HR positive + HER-2 amplification (1)
HR positive + HER-2 mutation (1)
KRAS G12D + HER-2 amplification + TMB-H (1)
KRAS mutation + HER-2 positive (1)
MSI-H + HER-2 amplification (1)
MSI-H/dMMR + HER-2 mutation (1)
NF1 mutation + HER-2 positive (1)
PD-L1 overexpression + HER-2 exon 20 insertion (1)
PIK3C3 mutation + HER-2 positive (1)
PIK3CA H1047R + HER-2 amplification (1)
PIK3CA mutation + HER-2 amplification (1)
PIK3CA mutation + HER-2 positive (1)
PIK3CA mutation + HR positive + HER-2 negative (1)
PIK3R1 mutation + HER-2 positive (1)
RAS wild-type + HER-2 amplification (1)
RAS wild-type + HER-2 overexpression (1)
STAT6 deletion + HER-2 overexpression (1)
AHNAK2 mutation + TMB-H (1)
ALK mutation + TMB-H (1)
ARID1A mutation + TMB-H (1)
ARID1B mutation + TMB-H (1)
ASPSCR1-TFE3 fusion +TMB-H (1)
BAP1 deletion + TMB-L + PD-L1 expression (1)
BRAF mutation + TMB-H (1)
BRAF mutation + TMB-L + MSI-L/dMMR (1)
BRCA1 mutation + BRCA2 mutation + TMB-H (1)
BRCA2 mutation + TMB-H (1)
BRCA2 mutation + TMB-L (1)
CD20 positive + TMB-L (1)
CD74-ROS1 fusion + TMB-H (1)
CDKN2A mutation + TMB-H (1)
EGFR L858R + TMB-H (1)
EGFR T790M + TMB-H (1)
EGFR mutation + ALK negative + TMB-H (1)
ELF3 mutation + TMB-L + MSI-L/dMMR (1)
EML4-ALK fusion + TMB-L (1)
ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)
ERBB3 R135C + TMB-H (1)
HLA-E overexpression + TMB-L (1)
HR positive + TMB-H (1)
HR positive + TMB-L (1)
High IFNG gene signature + TMB-H (1)
IDH1 mutation + TMB-L (1)
IDH2 mutation + TMB-L (1)
KEAP1 mutation + TMB-H + PD-L1 overexpression (1)
KMT2C mutation + BCOR mutation + KDM5C mutation + TMB-H (1)
KMT2C mutation + TMB-H (1)
KRAS A146 + TMB-H (1)
MAP2K1 mutation + TMB-H (1)
MAP2K2 mutation + TMB-H (1)
MET mutation + TMB-H (1)
MGA mutation + TMB-L (1)
MGAM mutation + TMB-H (1)
MLH1 methylation + MSI-H/dMMR + TMB-H (1)
MSI-H/dMMR + TMB-H + POLE mutation (1)
NCR3LG1 underexpression + TMB-L (1)
NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)
NPAP1 mutation + TMB-H (1)
NTRK3 mutation + TMB-H (1)
PBRM1 mutation + TMB-H (1)
PBRM1 mutation + TMB-L + MSI-L/dMMR (1)
PD-L1 amplification + PD-L2 amplification + TMB-H (1)
PD-L1 negative + TMB-L (1)
PD-L1 negative + TMB-L + STING overexpression (1)
PD-L1 overexpression + TMB-H (1)
PD-L1 overexpression + TMB-H + ARID1A F2141fs*59 (1)
PD-L1 overexpression + TMB-L (1)
PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)
POLE P286R + TMB-H (1)
POLE V1368M + ERBB3 G1271S + TNFAIP3 P714A + PRKN I69T + TSC2 G1399R + TMB-L (1)
POLE mutation + PD-L1 negative + TMB-H (1)
PTCH1 1504-1G>T + TMB-H (1)
PTPN11 mutation + TMB-H (1)
PTPRD mutation + TMB-H (1)
RECQL5 mutation + TMB-H (1)
RET amplification + TMB-H + PD-L1 expression (1)
RYR1 mutation + TMB-H (1)
SMARCA4 mutation + TMB-H (1)
SMARCB1 mutation + TMB-H (1)
STK11 deletion + TMB-H (1)
STK11 mutation + TMB-H + PD-L1 overexpression (1)
TMB-H + ALK rearrangement (1)
TMB-H + CDKN2B mutation (1)
TMB-H + DDR (1)
TMB-H + KDM6A mutation (1)
TMB-H + LDH elevation (1)
TMB-H + MLL2 mutation (1)
TMB-H + MSH6 F1088fs (1)
TMB-H + PD-L1 expression + MSI-L/dMMR (1)
TMB-H + RB1 mutation + PD-L1 underexpression (1)
TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)
TMB-H + TERT promoter mutation (1)
TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23 (1)
TMB-L + LDH elevation (1)
TMB-L + PD-L1 underexpression (1)
TMB-L + RB1 mutation (1)
TP53 S12F + KRAS G12D + TMB-L (1)
TP53 mutation + FANCM mutation + TMB-H (1)
TP53 mutation + LRP1B mutation + TMB-H (1)
TP53 mutation + TMB-H + PD-L1 overexpression (1)
TPR mutation + TMB-H (1)
TTF1 expression + NAPSA expression + PD-L1 expression + TMB-H (1)
XIRP2 mutation + TMB-H (1)
ZNF479 mutation + TMB-H (1)
MSI-H/dMMR + POLE P286R (1)
ER negative + HER-2 positive + PIK3CA H1047R (0)
ER positive + HER-2 negative + ER mutation (0)
HER-2 amplification + KRAS G12C (0)
HER-2 exon 20 mutation + HER-2 amplification (0)
HER-2 positive + FGFR1 amplification (0)
HER-2-H (0)
HR positive + HER-2 negative + TMB-L (0)
PIK3CA E453K + HER-2 positive (0)
PIK3CA E542K + HER-2 positive (0)
PIK3CA E542Q + HER-2 positive (0)
PIK3CA H1047L + HER-2 positive (0)
PIK3CA H1047R + HER-2 positive (0)
PIK3CA N345K + HER-2 positive (0)
PIK3CA amplification + HER-2 positive (0)
NOTCH4 mutation + PD-L1 expression + TMB-H (0)
PIK3CA mutation + TMB-L + MSI-L/dMMR (0)
TMB-H (186)
TMB-L (25)
HER-2 amplification + RAS wild-type + BRAF wild-type (9)
MSI-H/dMMR + TMB-H (8)
TMB-H + PD-L1 overexpression (7)
MSI-H/dMMR + TMB-L (5)
HER-2 positive + HER-2 amplification (4)
RAS wild-type + HER-2 positive (4)
MSI-H/dMMR + POLE mutation (4)
HER-2 amplification + KRAS G12D (3)
BRCA1 mutation + TMB-H (3)
KMT2D mutation + TMB-H (3)
MLL3 mutation + TMB-H (3)
MSI-H/dMMR + TMB-H + PD-L1 negative (3)
PD-L1 expression + TMB-H (3)
BRAF wild-type + HER-2 positive (2)
BRCA1 mutation + HER-2 negative (2)
BRCA2 mutation + HER-2 negative (2)
HER-2 S310F + HER-2 amplification (2)
HER-2 amplification + EGFR-ZNF880 fusion + EGFR E114K (2)
HER-2 amplification + HER-2 L755S (2)
HER-2 amplification + PD-L1 expression (2)
HER-2 amplification + RAS wild-type (2)
HER-2 expression + HER-2 D769H (2)
HER-2 expression + HER-2 L869R (2)
HER-2 expression + HER-2 amplification (2)
HER-2 expression + TMB-H (2)
RAS wild-type + BRAF wild-type + HER-2 positive (2)
TMB-H + HER-2 positive (2)
EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)
LRP1B mutation + TMB-H (2)
MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)
NCOR2-NTRK1 fusion + TMB-H (2)
PAPPA2 mutation + TMB-H (2)
PD-L1 expression + TMB-H + FANCA deletion (2)
STK11 mutation + TMB-H (2)
TMB-H + EGFR exon 19 deletion (2)
TMB-H + EGFR mutation (2)
TMB-H + PD-L1 negative (2)
TMB-H + PD-L1 underexpression (2)
TMB-H + PIK3CA mutation (2)
TMB-L + BAP1 V99M + NF2 R34 + Chr del(14q) + Chr del(19q) (2)
TMB-L + PD-L1 expression (2)
AR positive + HER-2 amplification (1)
BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)
CD74-NRG1 fusion + EGFR mutation + HER-2 mutation (1)
EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)
EGFR T790M + HER-2 amplification (1)
EGFR exon 19 deletion + EGFR T790M + EGFR C797S + HER-2 amplification (1)
ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)
ER positive + HER-2 D769H + HER-2 V777L (1)
ERBB2 G778A + CCNE1 amplification (1)
ERBB3 mutation + HER-2 amplification (1)
ERBB4 mutation + HER-2 positive (1)
HER-2 amplification + AXL expression (1)
HER-2 amplification + BRAF wild-type (1)
HER-2 amplification + CCNE1 expression (1)
HER-2 amplification + EGFR mutation (1)
HER-2 amplification + ER positive + PGR negative (1)
HER-2 amplification + HER-2 R157W (1)
HER-2 amplification + HER-2 mutation (1)
HER-2 amplification + KRAS exon 2 wild-type (1)
HER-2 amplification + KRAS wild-type (1)
HER-2 elevation (1)
HER-2 elevation + TMB-H (1)
HER-2 elevation + TMB-L (1)
HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)
HER-2 mutation + HER-2 positive (1)
HER-2 mutation + TMB-H (1)
HER-2 overexpression + CCNE1 amplification (1)
HER-2 overexpression + HER-2 amplification (1)
HER-2 overexpression + KRAS G12C (1)
HER-2 overexpression + KRAS wild-type (1)
HER-2 overexpression + PTEN deletion (1)
HER-2 overexpression + RAS wild-type (1)
HER-2 positive + APC mutation (1)
HER-2 positive + GATA6 amplification (1)
HER-2 positive + MYC amplification (1)
HER-2 positive + TP53 mutation (1)
HER-2 underexpression + CCNE1 amplification (1)
HR positive + HER-2 amplification (1)
HR positive + HER-2 mutation (1)
KRAS G12D + HER-2 amplification + TMB-H (1)
KRAS mutation + HER-2 positive (1)
MSI-H + HER-2 amplification (1)
MSI-H/dMMR + HER-2 mutation (1)
NF1 mutation + HER-2 positive (1)
PD-L1 overexpression + HER-2 exon 20 insertion (1)
PIK3C3 mutation + HER-2 positive (1)
PIK3CA H1047R + HER-2 amplification (1)
PIK3CA mutation + HER-2 amplification (1)
PIK3CA mutation + HER-2 positive (1)
PIK3CA mutation + HR positive + HER-2 negative (1)
PIK3R1 mutation + HER-2 positive (1)
RAS wild-type + HER-2 amplification (1)
RAS wild-type + HER-2 overexpression (1)
STAT6 deletion + HER-2 overexpression (1)
AHNAK2 mutation + TMB-H (1)
ALK mutation + TMB-H (1)
ARID1A mutation + TMB-H (1)
ARID1B mutation + TMB-H (1)
ASPSCR1-TFE3 fusion +TMB-H (1)
BAP1 deletion + TMB-L + PD-L1 expression (1)
BRAF mutation + TMB-H (1)
BRAF mutation + TMB-L + MSI-L/dMMR (1)
BRCA1 mutation + BRCA2 mutation + TMB-H (1)
BRCA2 mutation + TMB-H (1)
BRCA2 mutation + TMB-L (1)
CD20 positive + TMB-L (1)
CD74-ROS1 fusion + TMB-H (1)
CDKN2A mutation + TMB-H (1)
EGFR L858R + TMB-H (1)
EGFR T790M + TMB-H (1)
EGFR mutation + ALK negative + TMB-H (1)
ELF3 mutation + TMB-L + MSI-L/dMMR (1)
EML4-ALK fusion + TMB-L (1)
ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)
ERBB3 R135C + TMB-H (1)
HLA-E overexpression + TMB-L (1)
HR positive + TMB-H (1)
HR positive + TMB-L (1)
High IFNG gene signature + TMB-H (1)
IDH1 mutation + TMB-L (1)
IDH2 mutation + TMB-L (1)
KEAP1 mutation + TMB-H + PD-L1 overexpression (1)
KMT2C mutation + BCOR mutation + KDM5C mutation + TMB-H (1)
KMT2C mutation + TMB-H (1)
KRAS A146 + TMB-H (1)
MAP2K1 mutation + TMB-H (1)
MAP2K2 mutation + TMB-H (1)
MET mutation + TMB-H (1)
MGA mutation + TMB-L (1)
MGAM mutation + TMB-H (1)
MLH1 methylation + MSI-H/dMMR + TMB-H (1)
MSI-H/dMMR + TMB-H + POLE mutation (1)
NCR3LG1 underexpression + TMB-L (1)
NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)
NPAP1 mutation + TMB-H (1)
NTRK3 mutation + TMB-H (1)
PBRM1 mutation + TMB-H (1)
PBRM1 mutation + TMB-L + MSI-L/dMMR (1)
PD-L1 amplification + PD-L2 amplification + TMB-H (1)
PD-L1 negative + TMB-L (1)
PD-L1 negative + TMB-L + STING overexpression (1)
PD-L1 overexpression + TMB-H (1)
PD-L1 overexpression + TMB-H + ARID1A F2141fs*59 (1)
PD-L1 overexpression + TMB-L (1)
PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)
POLE P286R + TMB-H (1)
POLE V1368M + ERBB3 G1271S + TNFAIP3 P714A + PRKN I69T + TSC2 G1399R + TMB-L (1)
POLE mutation + PD-L1 negative + TMB-H (1)
PTCH1 1504-1G>T + TMB-H (1)
PTPN11 mutation + TMB-H (1)
PTPRD mutation + TMB-H (1)
RECQL5 mutation + TMB-H (1)
RET amplification + TMB-H + PD-L1 expression (1)
RYR1 mutation + TMB-H (1)
SMARCA4 mutation + TMB-H (1)
SMARCB1 mutation + TMB-H (1)
STK11 deletion + TMB-H (1)
STK11 mutation + TMB-H + PD-L1 overexpression (1)
TMB-H + ALK rearrangement (1)
TMB-H + CDKN2B mutation (1)
TMB-H + DDR (1)
TMB-H + KDM6A mutation (1)
TMB-H + LDH elevation (1)
TMB-H + MLL2 mutation (1)
TMB-H + MSH6 F1088fs (1)
TMB-H + PD-L1 expression + MSI-L/dMMR (1)
TMB-H + RB1 mutation + PD-L1 underexpression (1)
TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)
TMB-H + TERT promoter mutation (1)
TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23 (1)
TMB-L + LDH elevation (1)
TMB-L + PD-L1 underexpression (1)
TMB-L + RB1 mutation (1)
TP53 S12F + KRAS G12D + TMB-L (1)
TP53 mutation + FANCM mutation + TMB-H (1)
TP53 mutation + LRP1B mutation + TMB-H (1)
TP53 mutation + TMB-H + PD-L1 overexpression (1)
TPR mutation + TMB-H (1)
TTF1 expression + NAPSA expression + PD-L1 expression + TMB-H (1)
XIRP2 mutation + TMB-H (1)
ZNF479 mutation + TMB-H (1)
MSI-H/dMMR + POLE P286R (1)
ER negative + HER-2 positive + PIK3CA H1047R (0)
ER positive + HER-2 negative + ER mutation (0)
HER-2 amplification + KRAS G12C (0)
HER-2 exon 20 mutation + HER-2 amplification (0)
HER-2 positive + FGFR1 amplification (0)
HER-2-H (0)
HR positive + HER-2 negative + TMB-L (0)
PIK3CA E453K + HER-2 positive (0)
PIK3CA E542K + HER-2 positive (0)
PIK3CA E542Q + HER-2 positive (0)
PIK3CA H1047L + HER-2 positive (0)
PIK3CA H1047R + HER-2 positive (0)
PIK3CA N345K + HER-2 positive (0)
PIK3CA amplification + HER-2 positive (0)
NOTCH4 mutation + PD-L1 expression + TMB-H (0)
PIK3CA mutation + TMB-L + MSI-L/dMMR (0)
›
Associations
News
Trials
VERI cancer hierarchy
Reset Filters
POLE E790Q + ERBB2 amplification + TMB-H
HER2 Positive Breast Cancer
POLE E790Q + ERBB2 amplification + TMB-H
HER2 Positive Breast Cancer
pembrolizumab + trastuzumab
Sensitive: C4 – Case Studies
pembrolizumab + trastuzumab
Sensitive
:
C4
pembrolizumab + trastuzumab
Sensitive: C4 – Case Studies
pembrolizumab + trastuzumab
Sensitive
:
C4
^
^
Full access to predictive biomarker details and heatmap analytics are available with a VERI Account.
Sign up for FREE
Already have an account?
Login
Full access to predictive biomarker details and heatmap analytics are available with a VERI Account.
Sign up for FREE
Already have an account?
Login