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BIOMARKER:
PIK3CA E542K
i
Other names:
PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alpha, PI3Kalpha, P110alpha, PI3K
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Entrez ID:
5290
Related biomarkers:
Expression
Mutation
CNA
Others
‹
PIK3CA mutation + HR positive (16)
PIK3CA mutation + ER positive (10)
PIK3CA mutation + PTEN deletion (5)
ER positive + PIK3CA H1047R (3)
HR-positive + PIK3CA wild-type (3)
PIK3CA exon 20 mutation + HR positive (3)
BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)
PIK3CA H1047R + PIK3C2B amplification (2)
PIK3CA mutation + ER negative (2)
PIK3CA mutation + HR negative (2)
PIK3CA mutation + MSI-L/dMMR (2)
TMB-H + PIK3CA mutation (2)
CCNE1 overexpression + PIK3CA muattion + ER positive (1)
CCNE2 overexpression + PIK3CA mutation + ER positive (1)
EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)
EGFR exon 19 deletion + PTEN deletion + PIK3CA overexpression (1)
ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)
ER positive + ESR1 mutation + PIK3CA mutation (1)
ESR1 mutation + PIK3CA mutation + HR positive (1)
HR positive + PIK3CA exon 10 mutation (1)
HRAS overexpression + PIK3CA amplification (1)
HRAS overexpression + PIK3CA mutation (1)
KRAS mutation + PIK3CA wild-type (1)
MET amplification + PIK3CA mutation (1)
MTAP deletion + PIK3CA mutation (1)
MYB fusion + PIK3CA mutation (1)
PD-L1 expression + PIK3CA mutation (1)
PIK3CA E542K + HR positive (1)
PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)
PIK3CA H1047R + HER-2 amplification (1)
PIK3CA R88Q + PD-L1 expression (1)
PIK3CA amplification + PIK3CA mutation + HR positive (1)
PIK3CA exon 7 mutation + HR positive (1)
PIK3CA exon 9 mutation + HR positive (1)
PIK3CA mutation + ALK fusion (1)
PIK3CA mutation + ALK positive (1)
PIK3CA mutation + BRAF wild-type (1)
PIK3CA mutation + ESR1 wild-type (1)
PIK3CA mutation + HER-2 amplification (1)
PIK3CA mutation + HER-2 positive (1)
PIK3CA mutation + HR positive + HER-2 negative (1)
PIK3CA mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)
PIK3CA mutation + PTEN underexpression (1)
PIK3CA mutation + RAS wild-type (1)
PIK3CA mutation + TTN mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)
PIK3CA wild-type+ ESR1 wild-type (1)
SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)
ER negative + HER-2 positive + PIK3CA H1047R (0)
MYB fusion + PIK3CA amplification (0)
PIK3CA E453K + HER-2 positive (0)
PIK3CA E542K + HER-2 positive (0)
PIK3CA E542Q + HER-2 positive (0)
PIK3CA H1047L + HER-2 positive (0)
PIK3CA H1047R + HER-2 positive (0)
PIK3CA N345K + HER-2 positive (0)
PIK3CA amplification + HER-2 positive (0)
PIK3CA amplification + PTEN deletion (0)
PIK3CA mutation + ER negative + PGR positive (0)
PIK3CA mutation + PTEN expression (0)
PIK3CA mutation + TMB-L + MSI-L/dMMR (0)
PIK3CA mutation + HR positive (16)
PIK3CA mutation + ER positive (10)
PIK3CA mutation + PTEN deletion (5)
ER positive + PIK3CA H1047R (3)
HR-positive + PIK3CA wild-type (3)
PIK3CA exon 20 mutation + HR positive (3)
BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)
PIK3CA H1047R + PIK3C2B amplification (2)
PIK3CA mutation + ER negative (2)
PIK3CA mutation + HR negative (2)
PIK3CA mutation + MSI-L/dMMR (2)
TMB-H + PIK3CA mutation (2)
CCNE1 overexpression + PIK3CA muattion + ER positive (1)
CCNE2 overexpression + PIK3CA mutation + ER positive (1)
EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)
EGFR exon 19 deletion + PTEN deletion + PIK3CA overexpression (1)
ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)
ER positive + ESR1 mutation + PIK3CA mutation (1)
ESR1 mutation + PIK3CA mutation + HR positive (1)
HR positive + PIK3CA exon 10 mutation (1)
HRAS overexpression + PIK3CA amplification (1)
HRAS overexpression + PIK3CA mutation (1)
KRAS mutation + PIK3CA wild-type (1)
MET amplification + PIK3CA mutation (1)
MTAP deletion + PIK3CA mutation (1)
MYB fusion + PIK3CA mutation (1)
PD-L1 expression + PIK3CA mutation (1)
PIK3CA E542K + HR positive (1)
PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)
PIK3CA H1047R + HER-2 amplification (1)
PIK3CA R88Q + PD-L1 expression (1)
PIK3CA amplification + PIK3CA mutation + HR positive (1)
PIK3CA exon 7 mutation + HR positive (1)
PIK3CA exon 9 mutation + HR positive (1)
PIK3CA mutation + ALK fusion (1)
PIK3CA mutation + ALK positive (1)
PIK3CA mutation + BRAF wild-type (1)
PIK3CA mutation + ESR1 wild-type (1)
PIK3CA mutation + HER-2 amplification (1)
PIK3CA mutation + HER-2 positive (1)
PIK3CA mutation + HR positive + HER-2 negative (1)
PIK3CA mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)
PIK3CA mutation + PTEN underexpression (1)
PIK3CA mutation + RAS wild-type (1)
PIK3CA mutation + TTN mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)
PIK3CA wild-type+ ESR1 wild-type (1)
SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)
ER negative + HER-2 positive + PIK3CA H1047R (0)
MYB fusion + PIK3CA amplification (0)
PIK3CA E453K + HER-2 positive (0)
PIK3CA E542K + HER-2 positive (0)
PIK3CA E542Q + HER-2 positive (0)
PIK3CA H1047L + HER-2 positive (0)
PIK3CA H1047R + HER-2 positive (0)
PIK3CA N345K + HER-2 positive (0)
PIK3CA amplification + HER-2 positive (0)
PIK3CA amplification + PTEN deletion (0)
PIK3CA mutation + ER negative + PGR positive (0)
PIK3CA mutation + PTEN expression (0)
PIK3CA mutation + TMB-L + MSI-L/dMMR (0)
›
Related tests:
FoundationOne® CDx (110)
FoundationOne® Liquid CDx (21)
therascreen® PIK3CA RGQ PCR Kit (3)
FoundationOne® CDx (110)
FoundationOne® Liquid CDx (21)
therascreen® PIK3CA RGQ PCR Kit (3)
Associations
News
Trials
VERI cancer hierarchy
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PIK3CA E542K
HER2 Positive Breast Cancer
PIK3CA E542K
HER2 Positive Breast Cancer
trastuzumab
Sensitive: B - Late Trials
trastuzumab
Sensitive
:
B
trastuzumab
Sensitive: B - Late Trials
trastuzumab
Sensitive
:
B
PIK3CA E542K
HER2 Positive Breast Cancer
PIK3CA E542K
HER2 Positive Breast Cancer
PF-05212384 + trastuzumab-pkrb
Sensitive: C3 – Early Trials
PF-05212384 + trastuzumab-pkrb
Sensitive
:
C3
PF-05212384 + trastuzumab-pkrb
Sensitive: C3 – Early Trials
PF-05212384 + trastuzumab-pkrb
Sensitive
:
C3
PIK3CA E542K
Lung Adenocarcinoma
PIK3CA E542K
Lung Adenocarcinoma
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
crizotinib
Sensitive: C3 – Early Trials
crizotinib
Sensitive
:
C3
PIK3CA E542K
Colorectal Cancer
PIK3CA E542K
Colorectal Cancer
cetuximab
Resistant: C3 – Early Trials
cetuximab
Resistant
:
C3
cetuximab
Resistant: C3 – Early Trials
cetuximab
Resistant
:
C3
PIK3CA E542K
Squamous Cell Carcinoma of Head and Neck
PIK3CA E542K
Squamous Cell Carcinoma of Head and Neck
GDC-0980
Sensitive: C3 – Early Trials
GDC-0980
Sensitive
:
C3
GDC-0980
Sensitive: C3 – Early Trials
GDC-0980
Sensitive
:
C3
PIK3CA E542K
Soft Tissue Sarcoma
PIK3CA E542K
Soft Tissue Sarcoma
trametinib + pazopanib
Sensitive: C4 – Case Studies
trametinib + pazopanib
Sensitive
:
C4
trametinib + pazopanib
Sensitive: C4 – Case Studies
trametinib + pazopanib
Sensitive
:
C4
PIK3CA E542K
Gastric Cancer
PIK3CA E542K
Gastric Cancer
CYH33
Resistant: C4 – Case Studies
CYH33
Resistant
:
C4
CYH33
Resistant: C4 – Case Studies
CYH33
Resistant
:
C4
PIK3CA E542K
Breast Cancer
PIK3CA E542K
Breast Cancer
sirolimus
Sensitive: D – Preclinical
sirolimus
Sensitive
:
D
sirolimus
Sensitive: D – Preclinical
sirolimus
Sensitive
:
D
PIK3CA E542K
Squamous Cell Carcinoma of Head and Neck
PIK3CA E542K
Squamous Cell Carcinoma of Head and Neck
GDC-0032
Sensitive: D – Preclinical
GDC-0032
Sensitive
:
D
GDC-0032
Sensitive: D – Preclinical
GDC-0032
Sensitive
:
D
PIK3CA E542K
Squamous Cell Carcinoma of Head and Neck
PIK3CA E542K
Squamous Cell Carcinoma of Head and Neck
RTB101
Sensitive: D – Preclinical
RTB101
Sensitive
:
D
RTB101
Sensitive: D – Preclinical
RTB101
Sensitive
:
D
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