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DRUG:

Odomzo (sonidegib)

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Company:

Novartis, Sun Pharma

Drug class:

Hedgehog cell-signalling pathway inhibitor

Related drugs:

No biomarker	Basal Cell Carcinoma	No biomarker	Basal Cell Carcinoma	sonidegib Sensitive: A1 - Approval sonidegib Sensitive : A1	sonidegib Sensitive: A1 - Approval sonidegib Sensitive : A1
SMO W535L	Basal Cell Carcinoma	SMO W535L	Basal Cell Carcinoma	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4
SMO Q477E	Basal Cell Carcinoma	SMO Q477E	Basal Cell Carcinoma	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4
SMO D473H	Basal Cell Carcinoma	SMO D473H	Basal Cell Carcinoma	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4
SMO S533N	Basal Cell Carcinoma	SMO S533N	Basal Cell Carcinoma	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4
SMO D473G	Basal Cell Carcinoma	SMO D473G	Basal Cell Carcinoma	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4
ANIB1 overexpression	Pancreatic Ductal Adenocarcinoma	ANIB1 overexpression	Pancreatic Ductal Adenocarcinoma	sonidegib Sensitive: D – Preclinical sonidegib Sensitive : D	sonidegib Sensitive: D – Preclinical sonidegib Sensitive : D
SUFU deletion	Medulloblastoma	SUFU deletion	Medulloblastoma	sonidegib Resistant: D – Preclinical sonidegib Resistant : D	sonidegib Resistant: D – Preclinical sonidegib Resistant : D
MYCN amplification	Medulloblastoma	MYCN amplification	Medulloblastoma	sonidegib Resistant: D – Preclinical sonidegib Resistant : D	sonidegib Resistant: D – Preclinical sonidegib Resistant : D
PTCH1 mutation	Medulloblastoma	PTCH1 mutation	Medulloblastoma	sonidegib Sensitive: D – Preclinical sonidegib Sensitive : D	sonidegib Sensitive: D – Preclinical sonidegib Sensitive : D
GLI1 expression	Pancreatic Ductal Adenocarcinoma	GLI1 expression	Pancreatic Ductal Adenocarcinoma	sonidegib Sensitive: D – Preclinical sonidegib Sensitive : D	sonidegib Sensitive: D – Preclinical sonidegib Sensitive : D