^
Association details:
| Biomarker: | PTCH1 mutation |
|---|---|
| Cancer: | Medulloblastoma |
| Drug: | Odomzo (sonidegib) (Hedgehog cell-signalling pathway inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition
Excerpt:
...Treatment with LDE225 significantly inhibited the proliferation of DMB-012 cells (PTCH1 mutant)…
DOI:
10.1016%2Fj.ccr.2014.02.004
