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    DRUG:

    Odomzo (sonidegib)

    i
    Other names: LDE225, LDE 225, NVP LDE225, NVP-LDE225, LDE-225, NVPLDE225
    Company:
    Novartis, Sun Pharma
    Drug class:
    Hedgehog cell-signalling pathway inhibitor
    Related drugs:
    Apply
    SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors (NCT03434262)
    Phase 1
    St. Jude Children's Research Hospital
    Completed
    Last update posted :
    05/31/2024
    Initiation :
    03/05/2018
    Primary completion :
    09/30/2022
    Completion :
    05/24/2024
    PTCH1
    |
    PTCH1 mutation
    |
    Mekinist (trametinib) • gemcitabine • Kisqali (ribociclib) • Odomzo (sonidegib) • Neupogen (filgrastim)
    Sonidegib and Pembrolizumab in Treating Patients With Advanced Solid Tumors (NCT04007744)
    Phase 1
    Mayo Clinic
    Recruiting
    Last update posted :
    03/26/2024
    Initiation :
    02/13/2020
    Primary completion :
    07/01/2024
    Completion :
    07/01/2024
    EGFR • PD-L1 • BRAF • ALK • MSI • BCL2 • BCL2L11
    |
    PD-L1 expression • MSI-H/dMMR
    |
    Keytruda (pembrolizumab) • Odomzo (sonidegib)
    Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed Medulloblastoma (PersoMed-I) (NCT04402073)
    Phase 2
    European Organisation for Research and Treatmen...
    Recruiting
    Last update posted :
    12/11/2023
    Initiation :
    11/11/2022
    Primary completion :
    03/01/2030
    Completion :
    03/01/2030
    TP53 • BRCA2 • MYCN
    |
    TP53 wild-type • MYCN amplification
    |
    cisplatin • vincristine • lomustine • Odomzo (sonidegib)
    Study of LDE225 (Sonidegib) in Combination With Docetaxel in Triple Negative (TN) Advanced Breast Cancer (ABC) Patients (EDALINE) (NCT02027376)
    Phase 1
    Spanish Breast Cancer Research Group
    Completed
    Last update posted :
    04/03/2023
    Initiation :
    05/01/2014
    Primary completion :
    04/01/2016
    Completion :
    04/01/2016
    HER-2 • ER • PGR
    |
    HER-2 negative
    |
    docetaxel • Odomzo (sonidegib)
    Anti-PD1-antibody and Pulsed HHI for Advanced BCC (NCT04679480)
    Phase 2
    Reinhard Dummer
    Recruiting
    Last update posted :
    11/04/2022
    Initiation :
    02/18/2021
    Primary completion :
    12/30/2024
    Completion :
    12/30/2024
    CD8 • PD-1 • CD4 • CD200 • FOXP3
    |
    PD-L1 expression • PD-1 expression • BCL2 expression • CD20 expression • CD200 expression
    |
    Libtayo (cemiplimab-rwlc) • Odomzo (sonidegib)
    Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors (NCT01576666)
    Phase 1
    Novartis Pharmaceuticals
    Completed
    Last update posted :
    12/19/2020
    Initiation :
    07/01/2012
    Primary completion :
    04/01/2015
    Completion :
    04/01/2015
    HER-2 • PGR
    |
    HR positive
    |
    buparlisib (AN2025) • Odomzo (sonidegib)
    Nilotinib and LDE225 in the Treatment of Chronic or Accelerated Phase Myeloid Leukemia in Patients Who Developed Resistance to Prior Therapy (NCT01456676)
    Phase 1
    Novartis Pharmaceuticals
    Completed
    Last update posted :
    12/09/2020
    Initiation :
    01/01/2012
    Primary completion :
    02/01/2014
    Completion :
    02/01/2014
    ABL1 • BCR
    |
    nilotinib • Odomzo (sonidegib)
    Azacitidine and Sonidegib or Decitabine in Treating Patients With Myeloid Malignancies (NCT02129101)
    Phase 1
    Mayo Clinic
    Completed
    Last update posted :
    10/30/2019
    Initiation :
    05/01/2014
    Primary completion :
    12/31/2016
    Completion :
    10/25/2019
    JAK2
    |
    azacitidine • decitabine • Odomzo (sonidegib)
    A Pre-surgical Study of LDE225 in Men With High-risk Localized Prostate Cancer (NCT02111187)
    Phase 1
    Sidney Kimmel Comprehensive Cancer Center at Jo...
    Completed
    Last update posted :
    03/07/2019
    Initiation :
    04/01/2014
    Primary completion :
    01/18/2017
    Completion :
    01/18/2017
    GLI1
    |
    GLI1 expression
    |
    Odomzo (sonidegib)
    Pilot LDE225 in Locally Advanced or Metastatic BCC + Previously Tx Non-LDE225 Smoothened Inhibitors (NCT01529450)
    Phase N/A
    Anne Chang
    Completed
    Last update posted :
    01/16/2017
    Initiation :
    02/01/2012
    Primary completion :
    08/01/2013
    Completion :
    08/01/2013
    PTCH1
    |
    Odomzo (sonidegib)