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Association details:
| Biomarker: | ANIB1 overexpression |
|---|---|
| Cancer: | Pancreatic Ductal Adenocarcinoma |
| Drug: | Odomzo (sonidegib) (Hedgehog cell-signalling pathway inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation
Published date:
01/01/2021
Excerpt:
PDAC cells with high AIB1 levels were sensitive to Hh signaling inhibitors, suggesting that blocking Hh activation is an effective treatment against PDAC with high AIB1 expression...Furthermore, this study indicates that PDAC cells with high AIB1 levels are more sensitive to hedgehog inhibitors, which provides a novel potential strategy for precisely treating PDAC.
DOI:
10.7150/thno.47390
