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    Association details:
    Biomarker:MYCN amplification
    Cancer:Medulloblastoma
    Drug:Odomzo (sonidegib) (Hedgehog cell-signalling pathway inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    New
    Source:
    Cancer Cell
    Title:

    Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

    Excerpt:
    SHH Medulloblastomas with Mutations Downstream of SMO Are Resistant to LDE-225...Treatment with LDE225 significantly inhibited the proliferation of DMB-012 cells (PTCH1 mutant), but did not affect the proliferation of RCMB-018 (MYCN amplification) or RCMB-025 cells (SUFU deletion…
    DOI:
    10.1016%2Fj.ccr.2014.02.004