^
    Back
    Association details:
    Biomarker:GLI1 expression
    Cancer:Pancreatic Ductal Adenocarcinoma
    Drug:Odomzo (sonidegib) (Hedgehog cell-signalling pathway inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Mol Cancer Ther
    Title:

    Tumor priming by SMO inhibition enhances antibody delivery and efficacy in a pancreatic ductal adenocarcinoma model

    Published date:
    07/30/2019
    Excerpt:
    In contrast, murine Gli1 expression was abundant, and all PDX tumors responded to 40 and 80 mg/kg/day NVP-LDE225 with time-dependent Gli1 suppression (Fig. 1B, S2B, S3).
    DOI:
    10.1158/1535-7163.MCT-18-0354