^
Association details:
Evidence:
Evidence Level:
Resistant: D – Preclinical
New
Title:

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

Excerpt:
SHH Medulloblastomas with Mutations Downstream of SMO Are Resistant to LDE-225...Treatment with LDE225 significantly inhibited the proliferation of DMB-012 cells (PTCH1 mutant), but did not affect the proliferation of RCMB-018 (MYCN amplification) or RCMB-025 cells (SUFU deletion…
DOI:
10.10162Fj.ccr.2014.02.004