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    Association details:
    Biomarker:PD-L1 expression
    Cancer:Melanoma
    Drug:Leukeran (chlorambucil) (Alkylating agent)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Eur J Hosp Pharm
    Title:

    Pharmacological tumor PDL1 depletion with chlorambucil treats ovarian cancer and melanoma: improves antitumor immunity and renders anti-PDL1-resistant tumors anti-PDL1-sensitive through NK cell effects

    Published date:
    02/01/2023
    Excerpt:
    PDL1-expressing mouse and human ovarian cancer lines and mouse melanoma were more sensitive to chlorambucil-mediated proliferation inhibition in vitro versus corresponding genetically PDL1-depleted lines. Orthotopic peritoneal PDL1-expressing ID8agg ovarian cancer and subcutaneous B16 melanoma tumors were more chlorambucil-sensitive in vivo...
    DOI:
    http://dx.doi.org/10.1136/jitc-2022-004871