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BIOMARKER:
KRAS mutation
i
Other names:
KRAS, KRAS1, KRAS2, Kirsten rat sarcoma viral oncogene homolog
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Entrez ID:
3845
Related biomarkers:
Expression
Mutation
CNA
Others
‹
KRAS G12C (159)
KRAS G12D (64)
KRAS G12V (36)
KRAS wild-type (26)
KRAS G13D (22)
KRAS G12R (18)
RAS wild-type (17)
KRAS G12A (14)
KRAS G12 (10)
KRAS G12S (9)
KRAS G13 (8)
KRAS mutation + STK11 mutation (8)
KRAS Q61H (7)
KRAS exon 2 mutation (7)
TP53 mutation + KRAS mutation (6)
KRAS G12C + STK11 mutation (5)
EGFR mutation + KRAS mutation (4)
KRAS A146 (4)
KRAS A59T (4)
KRAS Q61 (4)
KRAS A146T (3)
KRAS G12C + TP53 mutation (3)
KRAS G12D + STK11 mutation (3)
KRAS Y96D (3)
KRAS Y96S (3)
EGFR T790M + KRAS mutation (2)
EGFR V802I + KRAS mutation (2)
KEAP1 mutation + KRAS mutation (2)
KRAS A146V (2)
KRAS A59 (2)
KRAS A59S (2)
KRAS G12C + KEAP1 mutation (2)
KRAS G12D + KRAS G12V (2)
KRAS G13A (2)
KRAS G13C (2)
KRAS G13D + BRAF mutation (2)
KRAS K117 (2)
KRAS Q99L (2)
KRAS R68M (2)
KRAS exon 12 mutation (2)
KRAS exon 2 wild-type (2)
KRAS exon 3 mutation (2)
KRAS exon 4 mutation (2)
KRAS mutation + EGFR wild-type (2)
KRAS mutation + STK11 mutation + KEAP1 mutation (2)
KRAS mutation + TP53 wild-type (2)
PIK3CA mutation + KRAS mutation (2)
STK11 mutation + KEAP1 mutation + KRAS G12C (2)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + KRAS mutation (1)
APC mutation + KRAS mutation (1)
ARID1A mutation+ KRAS G12C (1)
BRAF V600E + KRAS G12R (1)
DICER1 A1690Gfs*9 + DICER1 E1813Q + KRAS G12L (1)
EGFR T790M + KRAS G12V (1)
KIR2DS4 mutation + KRAS mutation (1)
KRAS G12A + BRAF D549N (1)
KRAS G12C + ATM wild-type (1)
KRAS G12C + KRAS G12V (1)
KRAS G12C + SMARCA4 wild-type (1)
KRAS G12D + DNMT3A C559fsX (1)
KRAS G12V + BRAF V600E (1)
KRAS G12V + STK11 mutation (1)
KRAS G12V + TP53 mutation + APC mutation (1)
KRAS G60D (1)
KRAS G61 (1)
KRAS G61H + KRAS G12A (1)
KRAS N116H (1)
KRAS N116T (1)
KRAS Q22X (1)
KRAS Q61K (1)
KRAS Q61L (1)
KRAS S89P (1)
KRAS V12 (1)
KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)
KRAS exon 13 mutation (1)
KRAS mutation + ATM mutation (1)
KRAS mutation + KEAP1 mutation (1)
KRAS mutation + SMARCA4 mutation (1)
KRAS mutation + STK11 deletion + KEAP1 deletion (1)
KRAS mutation + STK11 mutation + TP53 mutation (1)
KRAS mutation + U2AF1 mutation (1)
KRAS mutation + KMT2C mutation (1)
MAP2K1 G128D + KRAS mutation (1)
MET exon 14 mutation + KRAS G12A (1)
NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)
PIK3CA mutation + PTEN mutation + KRAS mutation (1)
PIK3CA wild-type + KRAS wild-type (1)
PTPN11 mutation + KRAS wild-type (1)
STK11 mutation + KEAP1 mutation + KRAS wild-type (1)
BRAF V600E + KRAS G12D (0)
CDKN2A mutation + CDKN2B mutation + KRAS mutation (0)
CDKN2A mutation + KRAS mutation (0)
KRAS A146P (0)
KRAS A59 (0)
KRAS G61H (0)
KRAS mutation + TP53 mutation (0)
KRAS G12C (159)
KRAS G12D (64)
KRAS G12V (36)
KRAS wild-type (26)
KRAS G13D (22)
KRAS G12R (18)
RAS wild-type (17)
KRAS G12A (14)
KRAS G12 (10)
KRAS G12S (9)
KRAS G13 (8)
KRAS mutation + STK11 mutation (8)
KRAS Q61H (7)
KRAS exon 2 mutation (7)
TP53 mutation + KRAS mutation (6)
KRAS G12C + STK11 mutation (5)
EGFR mutation + KRAS mutation (4)
KRAS A146 (4)
KRAS A59T (4)
KRAS Q61 (4)
KRAS A146T (3)
KRAS G12C + TP53 mutation (3)
KRAS G12D + STK11 mutation (3)
KRAS Y96D (3)
KRAS Y96S (3)
EGFR T790M + KRAS mutation (2)
EGFR V802I + KRAS mutation (2)
KEAP1 mutation + KRAS mutation (2)
KRAS A146V (2)
KRAS A59 (2)
KRAS A59S (2)
KRAS G12C + KEAP1 mutation (2)
KRAS G12D + KRAS G12V (2)
KRAS G13A (2)
KRAS G13C (2)
KRAS G13D + BRAF mutation (2)
KRAS K117 (2)
KRAS Q99L (2)
KRAS R68M (2)
KRAS exon 12 mutation (2)
KRAS exon 2 wild-type (2)
KRAS exon 3 mutation (2)
KRAS exon 4 mutation (2)
KRAS mutation + EGFR wild-type (2)
KRAS mutation + STK11 mutation + KEAP1 mutation (2)
KRAS mutation + TP53 wild-type (2)
PIK3CA mutation + KRAS mutation (2)
STK11 mutation + KEAP1 mutation + KRAS G12C (2)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + KRAS mutation (1)
APC mutation + KRAS mutation (1)
ARID1A mutation+ KRAS G12C (1)
BRAF V600E + KRAS G12R (1)
DICER1 A1690Gfs*9 + DICER1 E1813Q + KRAS G12L (1)
EGFR T790M + KRAS G12V (1)
KIR2DS4 mutation + KRAS mutation (1)
KRAS G12A + BRAF D549N (1)
KRAS G12C + ATM wild-type (1)
KRAS G12C + KRAS G12V (1)
KRAS G12C + SMARCA4 wild-type (1)
KRAS G12D + DNMT3A C559fsX (1)
KRAS G12V + BRAF V600E (1)
KRAS G12V + STK11 mutation (1)
KRAS G12V + TP53 mutation + APC mutation (1)
KRAS G60D (1)
KRAS G61 (1)
KRAS G61H + KRAS G12A (1)
KRAS N116H (1)
KRAS N116T (1)
KRAS Q22X (1)
KRAS Q61K (1)
KRAS Q61L (1)
KRAS S89P (1)
KRAS V12 (1)
KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)
KRAS exon 13 mutation (1)
KRAS mutation + ATM mutation (1)
KRAS mutation + KEAP1 mutation (1)
KRAS mutation + SMARCA4 mutation (1)
KRAS mutation + STK11 deletion + KEAP1 deletion (1)
KRAS mutation + STK11 mutation + TP53 mutation (1)
KRAS mutation + U2AF1 mutation (1)
KRAS mutation + KMT2C mutation (1)
MAP2K1 G128D + KRAS mutation (1)
MET exon 14 mutation + KRAS G12A (1)
NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)
PIK3CA mutation + PTEN mutation + KRAS mutation (1)
PIK3CA wild-type + KRAS wild-type (1)
PTPN11 mutation + KRAS wild-type (1)
STK11 mutation + KEAP1 mutation + KRAS wild-type (1)
BRAF V600E + KRAS G12D (0)
CDKN2A mutation + CDKN2B mutation + KRAS mutation (0)
CDKN2A mutation + KRAS mutation (0)
KRAS A146P (0)
KRAS A59 (0)
KRAS G61H (0)
KRAS mutation + TP53 mutation (0)
›
Related tests:
Oncomine™ Dx Target Test (10)
Idylla™ ctKRAS Mutation Test
Lung Cancer 8-Gene Kit
Oncomine™ Dx Target Test (10)
Idylla™ ctKRAS Mutation Test
Lung Cancer 8-Gene Kit
Associations
News
Trials
VERI cancer hierarchy
Reset Filters
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
cetuximab
Resistant: B - Late Trials
cetuximab
Resistant
:
B
cetuximab
Resistant: B - Late Trials
cetuximab
Resistant
:
B
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
trifluridine/tipiracil
Sensitive: B - Late Trials
trifluridine / tipiracil
Sensitive
:
B
trifluridine/tipiracil
Sensitive: B - Late Trials
trifluridine / tipiracil
Sensitive
:
B
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
bevacizumab
Sensitive: B - Late Trials
bevacizumab
Sensitive
:
B
bevacizumab
Sensitive: B - Late Trials
bevacizumab
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
pembrolizumab
Sensitive: B - Late Trials
pembrolizumab
Sensitive
:
B
pembrolizumab
Sensitive: B - Late Trials
pembrolizumab
Sensitive
:
B
KRAS mutation
Acute Myelogenous Leukemia
KRAS mutation
Acute Myelogenous Leukemia
gilteritinib
Resistant: B - Late Trials
gilteritinib
Resistant
:
B
gilteritinib
Resistant: B - Late Trials
gilteritinib
Resistant
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
abemaciclib
Sensitive: B - Late Trials
abemaciclib
Sensitive
:
B
abemaciclib
Sensitive: B - Late Trials
abemaciclib
Sensitive
:
B
KRAS mutation
Lung Non-Squamous Non-Small Cell Cancer
KRAS mutation
Lung Non-Squamous Non-Small Cell Cancer
bevacizumab + atezolizumab
Sensitive: B - Late Trials
bevacizumab + atezolizumab
Sensitive
:
B
bevacizumab + atezolizumab
Sensitive: B - Late Trials
bevacizumab + atezolizumab
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
gefitinib
Sensitive: B - Late Trials
gefitinib
Sensitive
:
B
gefitinib
Sensitive: B - Late Trials
gefitinib
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
selumetinib
Sensitive: B - Late Trials
selumetinib
Sensitive
:
B
selumetinib
Sensitive: B - Late Trials
selumetinib
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
Immunotherapy
Sensitive: B - Late Trials
Immunotherapy
Sensitive
:
B
Immunotherapy
Sensitive: B - Late Trials
Immunotherapy
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
nivolumab
Sensitive: B - Late Trials
nivolumab
Sensitive
:
B
nivolumab
Sensitive: B - Late Trials
nivolumab
Sensitive
:
B
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
regorafenib
Sensitive: B - Late Trials
regorafenib
Sensitive
:
B
regorafenib
Sensitive: B - Late Trials
regorafenib
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
erlotinib
Resistant: B - Late Trials
erlotinib
Resistant
:
B
erlotinib
Resistant: B - Late Trials
erlotinib
Resistant
:
B
KRAS mutation
Thyroid Gland Medullary Carcinoma
KRAS mutation
Thyroid Gland Medullary Carcinoma
cabozantinib capsule
Sensitive: B - Late Trials
cabozantinib capsule
Sensitive
:
B
cabozantinib capsule
Sensitive: B - Late Trials
cabozantinib capsule
Sensitive
:
B
KRAS mutation
Thyroid Gland Medullary Carcinoma
KRAS mutation
Thyroid Gland Medullary Carcinoma
cabozantinib capsule
Sensitive: B - Late Trials
cabozantinib capsule
Sensitive
:
B
cabozantinib capsule
Sensitive: B - Late Trials
cabozantinib capsule
Sensitive
:
B
KRAS mutation
Ovarian Cancer
KRAS mutation
Ovarian Cancer
binimetinib
Sensitive: B - Late Trials
binimetinib
Sensitive
:
B
binimetinib
Sensitive: B - Late Trials
binimetinib
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
durvalumab + tremelimumab
Sensitive: B - Late Trials
durvalumab + tremelimumab
Sensitive
:
B
durvalumab + tremelimumab
Sensitive: B - Late Trials
durvalumab + tremelimumab
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
pembrolizumab + abemaciclib
Sensitive: C2 – Inclusion Criteria
pembrolizumab + abemaciclib
Sensitive
:
C2
pembrolizumab + abemaciclib
Sensitive: C2 – Inclusion Criteria
pembrolizumab + abemaciclib
Sensitive
:
C2
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
bevacizumab + PCM-075
Sensitive: C2 – Inclusion Criteria
bevacizumab + PCM-075
Sensitive
:
C2
bevacizumab + PCM-075
Sensitive: C2 – Inclusion Criteria
bevacizumab + PCM-075
Sensitive
:
C2
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
trametinib
Sensitive: C2 – Inclusion Criteria
trametinib
Sensitive
:
C2
trametinib
Sensitive: C2 – Inclusion Criteria
trametinib
Sensitive
:
C2
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
afatinib + selumetinib
Sensitive: C2 – Inclusion Criteria
afatinib + selumetinib
Sensitive
:
C2
afatinib + selumetinib
Sensitive: C2 – Inclusion Criteria
afatinib + selumetinib
Sensitive
:
C2
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
trametinib
Sensitive: C2 – Inclusion Criteria
trametinib
Sensitive
:
C2
trametinib
Sensitive: C2 – Inclusion Criteria
trametinib
Sensitive
:
C2
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
eFT226
Sensitive: C2 – Inclusion Criteria
eFT226
Sensitive
:
C2
eFT226
Sensitive: C2 – Inclusion Criteria
eFT226
Sensitive
:
C2
KRAS mutation
Ovarian Cancer
KRAS mutation
Ovarian Cancer
VS-6766
Sensitive: C2 – Inclusion Criteria
VS-6766
Sensitive
:
C2
VS-6766
Sensitive: C2 – Inclusion Criteria
VS-6766
Sensitive
:
C2
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
VS-6766
Sensitive: C2 – Inclusion Criteria
VS-6766
Sensitive
:
C2
VS-6766
Sensitive: C2 – Inclusion Criteria
VS-6766
Sensitive
:
C2
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
momelotinib
Sensitive: C2 – Inclusion Criteria
momelotinib
Sensitive
:
C2
momelotinib
Sensitive: C2 – Inclusion Criteria
momelotinib
Sensitive
:
C2
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
sunitinib
Sensitive: C2 – Inclusion Criteria
sunitinib
Sensitive
:
C2
sunitinib
Sensitive: C2 – Inclusion Criteria
sunitinib
Sensitive
:
C2
KRAS mutation
Ovarian Cancer
KRAS mutation
Ovarian Cancer
VS-6766 + VS-6063
Sensitive: C2 – Inclusion Criteria
VS-6766 + VS-6063
Sensitive
:
C2
VS-6766 + VS-6063
Sensitive: C2 – Inclusion Criteria
VS-6766 + VS-6063
Sensitive
:
C2
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
bevacizumab + cetuximab
Sensitive: C2 – Inclusion Criteria
bevacizumab + cetuximab
Sensitive
:
C2
bevacizumab + cetuximab
Sensitive: C2 – Inclusion Criteria
bevacizumab + cetuximab
Sensitive
:
C2
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
palbociclib + binimetinib
Sensitive: C2 – Inclusion Criteria
palbociclib + binimetinib
Sensitive
:
C2
palbociclib + binimetinib
Sensitive: C2 – Inclusion Criteria
palbociclib + binimetinib
Sensitive
:
C2
KRAS mutation
Melanoma
KRAS mutation
Melanoma
trametinib
Sensitive: C2 – Inclusion Criteria
trametinib
Sensitive
:
C2
trametinib
Sensitive: C2 – Inclusion Criteria
trametinib
Sensitive
:
C2
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
cetuximab + selumetinib
Sensitive: C2 – Inclusion Criteria
cetuximab + selumetinib
Sensitive
:
C2
cetuximab + selumetinib
Sensitive: C2 – Inclusion Criteria
cetuximab + selumetinib
Sensitive
:
C2
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