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BIOMARKER:
KRAS mutation
i
Other names:
KRAS, KRAS1, KRAS2, Kirsten rat sarcoma viral oncogene homolog
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Entrez ID:
3845
Related biomarkers:
Expression
Mutation
CNA
Others
‹
STK11 deletion + KRAS mutation (6)
KRAS G12C + PD-L1 overexpression (4)
KRAS mutation + PD-L1 expression (4)
CPS1 overexpression + KRAS mutation + STK11 mutation (3)
HER-2 amplification + KRAS G12D (3)
KEAP1 deletion + KRAS mutation (3)
PD-L1 overexpression + KRAS mutation (3)
EGFR exon 19 deletion + KRAS mutation (2)
KRAS G12C + PD-L1 underexpression (2)
KRAS mutation + PD-L1 negative (2)
MSI-L/dMMR + KRAS G12V (2)
AXL overexpression + KRAS G12C (1)
CDH2 overexpression + KRAS wild-type (1)
Chr t(11;14) + KRAS mutation (1)
EGFR C797S + KRAS amplification + RB1 deletion (1)
EGFR L858R + KRAS amplification + RB1 deletion (1)
EGFR T790M + KRAS amplification + RB1 deletion (1)
EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)
EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)
EGFR expression + KRAS G12C (1)
EGFR overexpression + KRAS 13D (1)
EGFR overexpression + KRAS mutation (1)
FGFR1 overexpression + KRAS G12C (1)
GNA13 deletion + KRAS mutation (1)
GOPC-ROS1 fusion + KRAS Q61H (1)
HER-2 amplification + KRAS exon 2 wild-type (1)
HER-2 amplification + KRAS wild-type (1)
HER-2 overexpression + KRAS wild-type (1)
IGF1R overexpression + KRAS mutation (1)
IR overexpression + KRAS mutation (1)
IRS2 amplification + KRAS mutation (1)
KEAP1 mutation + KRAS wild-type (1)
KRAS A146 + TMB-H (1)
KRAS G12C + PD-L1 expression (1)
KRAS G12C + PD-L1 underexpression + STK11 mutation (1)
KRAS G12D + Chr del(9)(p21) (1)
KRAS G12D + HER-2 amplification + TMB-H (1)
KRAS G12D + TP53 deletion (1)
KRAS amplification + BRAF wild-type (1)
KRAS amplification + RAS wild-type (1)
KRAS mutation + PTPN11 overexpression + PD-L1 overexpression (1)
KRAS mutation + BCL2A1 overexpression (1)
KRAS mutation + CDK9 overexpression + HR positive (1)
KRAS mutation + EGFR amplification (1)
KRAS mutation + ER expression (1)
KRAS mutation + HER-2 positive (1)
KRAS mutation + HR positive (1)
KRAS mutation + PD-L1 underexpression (1)
KRAS mutation + PIK3CA wild-type (1)
KRAS mutation + PTPN11 overexpression (1)
KRAS mutation + TP53 mutation + GNA13 deletion (1)
KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)
KRAS mutation + YKL-40 overexpression (1)
KRAS wild-type + BRAF V600E (1)
KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)
KRAS mutation + STK11 mutation + AXL expression (1)
MLL-AFF1 fusion + KRAS mutation (1)
MSI-H/dMMR + KRAS G12D (1)
MSI-H/dMMR + KRAS Mutation (1)
MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)
MTAP deletion + KRAS G12C (1)
PD-L1 negative + KRAS G12C (1)
PD-L1 overexpression + KRAS G12C + TP53 mutation (1)
POMK-NRG1 fusion + KRAS mutation (1)
POMK‐NRG1 fusion + KRAS G12D (1)
PTEN deletion + KRAS G12C (1)
RET positive + KRAS G12V (1)
ROS1 fusion + KRAS G12C (1)
STK11 mutation + KRAS mutation + TP53 deletion (1)
STRN-ALK fusion + KRAS G13D (1)
TP53 S12F + KRAS G12D + TMB-L (1)
HER-2 amplification + KRAS G12C (0)
PRMT5 overexpression + KRAS mutation (0)
STK11 deletion + KRAS mutation (6)
KRAS G12C + PD-L1 overexpression (4)
KRAS mutation + PD-L1 expression (4)
CPS1 overexpression + KRAS mutation + STK11 mutation (3)
HER-2 amplification + KRAS G12D (3)
KEAP1 deletion + KRAS mutation (3)
PD-L1 overexpression + KRAS mutation (3)
EGFR exon 19 deletion + KRAS mutation (2)
KRAS G12C + PD-L1 underexpression (2)
KRAS mutation + PD-L1 negative (2)
MSI-L/dMMR + KRAS G12V (2)
AXL overexpression + KRAS G12C (1)
CDH2 overexpression + KRAS wild-type (1)
Chr t(11;14) + KRAS mutation (1)
EGFR C797S + KRAS amplification + RB1 deletion (1)
EGFR L858R + KRAS amplification + RB1 deletion (1)
EGFR T790M + KRAS amplification + RB1 deletion (1)
EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)
EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)
EGFR expression + KRAS G12C (1)
EGFR overexpression + KRAS 13D (1)
EGFR overexpression + KRAS mutation (1)
FGFR1 overexpression + KRAS G12C (1)
GNA13 deletion + KRAS mutation (1)
GOPC-ROS1 fusion + KRAS Q61H (1)
HER-2 amplification + KRAS exon 2 wild-type (1)
HER-2 amplification + KRAS wild-type (1)
HER-2 overexpression + KRAS wild-type (1)
IGF1R overexpression + KRAS mutation (1)
IR overexpression + KRAS mutation (1)
IRS2 amplification + KRAS mutation (1)
KEAP1 mutation + KRAS wild-type (1)
KRAS A146 + TMB-H (1)
KRAS G12C + PD-L1 expression (1)
KRAS G12C + PD-L1 underexpression + STK11 mutation (1)
KRAS G12D + Chr del(9)(p21) (1)
KRAS G12D + HER-2 amplification + TMB-H (1)
KRAS G12D + TP53 deletion (1)
KRAS amplification + BRAF wild-type (1)
KRAS amplification + RAS wild-type (1)
KRAS mutation + PTPN11 overexpression + PD-L1 overexpression (1)
KRAS mutation + BCL2A1 overexpression (1)
KRAS mutation + CDK9 overexpression + HR positive (1)
KRAS mutation + EGFR amplification (1)
KRAS mutation + ER expression (1)
KRAS mutation + HER-2 positive (1)
KRAS mutation + HR positive (1)
KRAS mutation + PD-L1 underexpression (1)
KRAS mutation + PIK3CA wild-type (1)
KRAS mutation + PTPN11 overexpression (1)
KRAS mutation + TP53 mutation + GNA13 deletion (1)
KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)
KRAS mutation + YKL-40 overexpression (1)
KRAS wild-type + BRAF V600E (1)
KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)
KRAS mutation + STK11 mutation + AXL expression (1)
MLL-AFF1 fusion + KRAS mutation (1)
MSI-H/dMMR + KRAS G12D (1)
MSI-H/dMMR + KRAS Mutation (1)
MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)
MTAP deletion + KRAS G12C (1)
PD-L1 negative + KRAS G12C (1)
PD-L1 overexpression + KRAS G12C + TP53 mutation (1)
POMK-NRG1 fusion + KRAS mutation (1)
POMK‐NRG1 fusion + KRAS G12D (1)
PTEN deletion + KRAS G12C (1)
RET positive + KRAS G12V (1)
ROS1 fusion + KRAS G12C (1)
STK11 mutation + KRAS mutation + TP53 deletion (1)
STRN-ALK fusion + KRAS G13D (1)
TP53 S12F + KRAS G12D + TMB-L (1)
HER-2 amplification + KRAS G12C (0)
PRMT5 overexpression + KRAS mutation (0)
›
Related tests:
Oncomine™ Dx Target Test (10)
Idylla™ ctKRAS Mutation Test
Lung Cancer 8-Gene Kit
Oncomine™ Dx Target Test (10)
Idylla™ ctKRAS Mutation Test
Lung Cancer 8-Gene Kit
Associations
News
Trials
VERI cancer hierarchy
Reset Filters
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
cetuximab
Resistant: B - Late Trials
cetuximab
Resistant
:
B
cetuximab
Resistant: B - Late Trials
cetuximab
Resistant
:
B
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
trifluridine/tipiracil
Sensitive: B - Late Trials
trifluridine / tipiracil
Sensitive
:
B
trifluridine/tipiracil
Sensitive: B - Late Trials
trifluridine / tipiracil
Sensitive
:
B
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
bevacizumab
Sensitive: B - Late Trials
bevacizumab
Sensitive
:
B
bevacizumab
Sensitive: B - Late Trials
bevacizumab
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
pembrolizumab
Sensitive: B - Late Trials
pembrolizumab
Sensitive
:
B
pembrolizumab
Sensitive: B - Late Trials
pembrolizumab
Sensitive
:
B
KRAS mutation
Acute Myelogenous Leukemia
KRAS mutation
Acute Myelogenous Leukemia
gilteritinib
Resistant: B - Late Trials
gilteritinib
Resistant
:
B
gilteritinib
Resistant: B - Late Trials
gilteritinib
Resistant
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
abemaciclib
Sensitive: B - Late Trials
abemaciclib
Sensitive
:
B
abemaciclib
Sensitive: B - Late Trials
abemaciclib
Sensitive
:
B
KRAS mutation
Lung Non-Squamous Non-Small Cell Cancer
KRAS mutation
Lung Non-Squamous Non-Small Cell Cancer
bevacizumab + atezolizumab
Sensitive: B - Late Trials
bevacizumab + atezolizumab
Sensitive
:
B
bevacizumab + atezolizumab
Sensitive: B - Late Trials
bevacizumab + atezolizumab
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
gefitinib
Sensitive: B - Late Trials
gefitinib
Sensitive
:
B
gefitinib
Sensitive: B - Late Trials
gefitinib
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
selumetinib
Sensitive: B - Late Trials
selumetinib
Sensitive
:
B
selumetinib
Sensitive: B - Late Trials
selumetinib
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
Immunotherapy
Sensitive: B - Late Trials
Immunotherapy
Sensitive
:
B
Immunotherapy
Sensitive: B - Late Trials
Immunotherapy
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
nivolumab
Sensitive: B - Late Trials
nivolumab
Sensitive
:
B
nivolumab
Sensitive: B - Late Trials
nivolumab
Sensitive
:
B
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
regorafenib
Sensitive: B - Late Trials
regorafenib
Sensitive
:
B
regorafenib
Sensitive: B - Late Trials
regorafenib
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
erlotinib
Resistant: B - Late Trials
erlotinib
Resistant
:
B
erlotinib
Resistant: B - Late Trials
erlotinib
Resistant
:
B
KRAS mutation
Thyroid Gland Medullary Carcinoma
KRAS mutation
Thyroid Gland Medullary Carcinoma
cabozantinib capsule
Sensitive: B - Late Trials
cabozantinib capsule
Sensitive
:
B
cabozantinib capsule
Sensitive: B - Late Trials
cabozantinib capsule
Sensitive
:
B
KRAS mutation
Thyroid Gland Medullary Carcinoma
KRAS mutation
Thyroid Gland Medullary Carcinoma
cabozantinib capsule
Sensitive: B - Late Trials
cabozantinib capsule
Sensitive
:
B
cabozantinib capsule
Sensitive: B - Late Trials
cabozantinib capsule
Sensitive
:
B
KRAS mutation
Ovarian Cancer
KRAS mutation
Ovarian Cancer
binimetinib
Sensitive: B - Late Trials
binimetinib
Sensitive
:
B
binimetinib
Sensitive: B - Late Trials
binimetinib
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
durvalumab + tremelimumab
Sensitive: B - Late Trials
durvalumab + tremelimumab
Sensitive
:
B
durvalumab + tremelimumab
Sensitive: B - Late Trials
durvalumab + tremelimumab
Sensitive
:
B
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
pembrolizumab + abemaciclib
Sensitive: C2 – Inclusion Criteria
pembrolizumab + abemaciclib
Sensitive
:
C2
pembrolizumab + abemaciclib
Sensitive: C2 – Inclusion Criteria
pembrolizumab + abemaciclib
Sensitive
:
C2
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
bevacizumab + PCM-075
Sensitive: C2 – Inclusion Criteria
bevacizumab + PCM-075
Sensitive
:
C2
bevacizumab + PCM-075
Sensitive: C2 – Inclusion Criteria
bevacizumab + PCM-075
Sensitive
:
C2
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
trametinib
Sensitive: C2 – Inclusion Criteria
trametinib
Sensitive
:
C2
trametinib
Sensitive: C2 – Inclusion Criteria
trametinib
Sensitive
:
C2
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
afatinib + selumetinib
Sensitive: C2 – Inclusion Criteria
afatinib + selumetinib
Sensitive
:
C2
afatinib + selumetinib
Sensitive: C2 – Inclusion Criteria
afatinib + selumetinib
Sensitive
:
C2
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
trametinib
Sensitive: C2 – Inclusion Criteria
trametinib
Sensitive
:
C2
trametinib
Sensitive: C2 – Inclusion Criteria
trametinib
Sensitive
:
C2
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
eFT226
Sensitive: C2 – Inclusion Criteria
eFT226
Sensitive
:
C2
eFT226
Sensitive: C2 – Inclusion Criteria
eFT226
Sensitive
:
C2
KRAS mutation
Ovarian Cancer
KRAS mutation
Ovarian Cancer
VS-6766
Sensitive: C2 – Inclusion Criteria
VS-6766
Sensitive
:
C2
VS-6766
Sensitive: C2 – Inclusion Criteria
VS-6766
Sensitive
:
C2
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
VS-6766
Sensitive: C2 – Inclusion Criteria
VS-6766
Sensitive
:
C2
VS-6766
Sensitive: C2 – Inclusion Criteria
VS-6766
Sensitive
:
C2
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
momelotinib
Sensitive: C2 – Inclusion Criteria
momelotinib
Sensitive
:
C2
momelotinib
Sensitive: C2 – Inclusion Criteria
momelotinib
Sensitive
:
C2
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
sunitinib
Sensitive: C2 – Inclusion Criteria
sunitinib
Sensitive
:
C2
sunitinib
Sensitive: C2 – Inclusion Criteria
sunitinib
Sensitive
:
C2
KRAS mutation
Ovarian Cancer
KRAS mutation
Ovarian Cancer
VS-6766 + VS-6063
Sensitive: C2 – Inclusion Criteria
VS-6766 + VS-6063
Sensitive
:
C2
VS-6766 + VS-6063
Sensitive: C2 – Inclusion Criteria
VS-6766 + VS-6063
Sensitive
:
C2
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
bevacizumab + cetuximab
Sensitive: C2 – Inclusion Criteria
bevacizumab + cetuximab
Sensitive
:
C2
bevacizumab + cetuximab
Sensitive: C2 – Inclusion Criteria
bevacizumab + cetuximab
Sensitive
:
C2
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
palbociclib + binimetinib
Sensitive: C2 – Inclusion Criteria
palbociclib + binimetinib
Sensitive
:
C2
palbociclib + binimetinib
Sensitive: C2 – Inclusion Criteria
palbociclib + binimetinib
Sensitive
:
C2
KRAS mutation
Melanoma
KRAS mutation
Melanoma
trametinib
Sensitive: C2 – Inclusion Criteria
trametinib
Sensitive
:
C2
trametinib
Sensitive: C2 – Inclusion Criteria
trametinib
Sensitive
:
C2
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
cetuximab + selumetinib
Sensitive: C2 – Inclusion Criteria
cetuximab + selumetinib
Sensitive
:
C2
cetuximab + selumetinib
Sensitive: C2 – Inclusion Criteria
cetuximab + selumetinib
Sensitive
:
C2
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