Median OS was 7.4 months with abemaciclib and 7.8 months with erlotinib...Median PFS was 3.6 months with abemaciclib and 1.9 months with erlotinib...The ORR was 8.9% (95% CI: 5.5, 12.3%) with abemaciclib and 2.7% (0.4, 5.1%) with erlotinib (p = 0.01). The disease control rate was 54.4% (95% CI: 48.5, 60.4%) with abemaciclib and 31.7% (25.0, 38.4%) with erlotinib...In previously treated patients with stage IV NSCLC harboring KRAS mutations, abemaciclib did not improve OS but demonstrated improvement in PFS and ORR compared with erlotinib.