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BIOMARKER:
KRAS G12C
i
Other names: KRAS, KRAS1, KRAS2, Kirsten rat sarcoma viral oncogene homolog
Entrez ID:
Related biomarkers:
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KRAS G12C
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NSCLC
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KRAS G12C
|
NSCLC
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MRTX849 Sensitive: B - Late Trials
Cancer Discov - 2 weeks (New B)
|
MRTX849 Sensitive: B - Late Trials
Cancer Discov - 2 weeks - (New C3)
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KRAS G12C
|
NSCLC
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KRAS G12C
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NSCLC
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sotorasib Sensitive: A1 - Approval
|
sotorasib Sensitive: A1 - Approval
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KRAS G12C
|
NSCLC
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KRAS G12C
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NSCLC
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Immunotherapy Sensitive: B - Late Trials
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Immunotherapy Sensitive: B - Late Trials
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KRAS G12C
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Lung Non-Squamous Non-Small Cell Cancer
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KRAS G12C
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Lung Non-Squamous Non-Small Cell Cancer
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Immunotherapy Sensitive: B - Late Trials
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Immunotherapy Sensitive: B - Late Trials
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KRAS G12C
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NSCLC
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KRAS G12C
|
NSCLC
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abemaciclib Sensitive: B - Late Trials
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abemaciclib Sensitive: B - Late Trials
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KRAS G12C
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NSCLC
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KRAS G12C
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NSCLC
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pembrolizumab Sensitive: B - Late Trials
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pembrolizumab Sensitive: B - Late Trials
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KRAS G12C
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CRC
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KRAS G12C
|
CRC
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cetuximab Resistant: B - Late Trials
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cetuximab Resistant: B - Late Trials
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KRAS G12C
|
CRC
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KRAS G12C
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CRC
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panitumumab Resistant: B - Late Trials
|
panitumumab Resistant: B - Late Trials
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KRAS G12C
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Ampulla of Vater Carcinoma
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KRAS G12C
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Ampulla of Vater Carcinoma
|
sotorasib Sensitive: C1 - Off-label
|
sotorasib Sensitive: C1 - Off-label
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KRAS G12C
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Pancreatic Cancer
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KRAS G12C
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Pancreatic Cancer
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sotorasib Sensitive: C1 - Off-label
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sotorasib Sensitive: C1 - Off-label
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KRAS G12C
|
Melanoma
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KRAS G12C
|
Melanoma
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sotorasib Sensitive: C1 - Off-label
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sotorasib Sensitive: C1 - Off-label
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KRAS G12C
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Endometrial Cancer
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KRAS G12C
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Endometrial Cancer
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sotorasib Sensitive: C1 - Off-label
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sotorasib Sensitive: C1 - Off-label
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KRAS G12C
|
CRC
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KRAS G12C
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CRC
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sotorasib Sensitive: C1 - Off-label
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sotorasib Sensitive: C1 - Off-label
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KRAS G12C
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Gastrointestinal Cancer
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KRAS G12C
|
Gastrointestinal Cancer
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sotorasib Sensitive: C1 - Off-label
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sotorasib Sensitive: C1 - Off-label
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KRAS G12C
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CRC
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KRAS G12C
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CRC
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MRTX849 Sensitive: C2 – Inclusion Criteria
|
MRTX849 Sensitive: C2 – Inclusion Criteria
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KRAS G12C
|
Solid Tumor
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KRAS G12C
|
Solid Tumor
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D-1553 Sensitive: C2 – Inclusion Criteria
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D-1553 Sensitive: C2 – Inclusion Criteria
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KRAS G12C
|
Lung Cancer
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KRAS G12C
|
Lung Cancer
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D-1553 Sensitive: C2 – Inclusion Criteria
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D-1553 Sensitive: C2 – Inclusion Criteria
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KRAS G12C
|
CRC
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KRAS G12C
|
CRC
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MEK inhibitor + sotorasib Sensitive: C2 – Inclusion Criteria
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MEK inhibitor + sotorasib Sensitive: C2 – Inclusion Criteria
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KRAS G12C
|
NSCLC
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KRAS G12C
|
NSCLC
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SAR442720 Sensitive: C2 – Inclusion Criteria
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SAR442720 Sensitive: C2 – Inclusion Criteria
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KRAS G12C
|
Gastrointestinal Cancer
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KRAS G12C
|
Gastrointestinal Cancer
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MRTX849 Sensitive: C2 – Inclusion Criteria
|
MRTX849 Sensitive: C2 – Inclusion Criteria
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KRAS G12C
|
Solid Tumor
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KRAS G12C
|
Solid Tumor
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GFH925 Sensitive: C2 – Inclusion Criteria
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GFH925 Sensitive: C2 – Inclusion Criteria
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KRAS G12C
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Solid Tumor
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KRAS G12C
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Solid Tumor
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JAB-21822 Sensitive: C2 – Inclusion Criteria
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JAB-21822 Sensitive: C2 – Inclusion Criteria
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KRAS G12C
|
NSCLC
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KRAS G12C
|
NSCLC
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selumetinib Sensitive: C3 – Early Trials
|
selumetinib Sensitive: C3 – Early Trials
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KRAS G12C
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Cholangiocarcinoma
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KRAS G12C
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Cholangiocarcinoma
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MRTX849 Sensitive: C3 – Early Trials
|
MRTX849 Sensitive: C3 – Early Trials
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KRAS G12C
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Ovarian Cancer
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KRAS G12C
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Ovarian Cancer
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MRTX849 Sensitive: C3 – Early Trials
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MRTX849 Sensitive: C3 – Early Trials
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KRAS G12C
|
Pancreatic Cancer
|
KRAS G12C
|
Pancreatic Cancer
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MRTX849 Sensitive: C3 – Early Trials
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MRTX849 Sensitive: C3 – Early Trials
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KRAS G12C
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Endometrial Cancer
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KRAS G12C
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Endometrial Cancer
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MRTX849 Sensitive: C3 – Early Trials
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MRTX849 Sensitive: C3 – Early Trials
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KRAS G12C
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CRC
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KRAS G12C
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CRC
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cetuximab + MRTX849 Sensitive: C3 – Early Trials
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cetuximab + MRTX849 Sensitive: C3 – Early Trials
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KRAS G12C
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NSCLC
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KRAS G12C
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NSCLC
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PD-L1 inhibitor Sensitive: C3 – Early Trials
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PD-L1 inhibitor Sensitive: C3 – Early Trials
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KRAS G12C
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Solid Tumor
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KRAS G12C
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Solid Tumor
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IN10018 + MRTX1257 Sensitive: C3 – Early Trials
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IN10018 + MRTX1257 Sensitive: C3 – Early Trials
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KRAS G12C
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HCC
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KRAS G12C
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HCC
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sorafenib + BAY86-9766 Sensitive: C3 – Early Trials
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sorafenib + BAY86-9766 Sensitive: C3 – Early Trials
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KRAS G12C
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NSCLC
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KRAS G12C
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NSCLC
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erlotinib Resistant: C3 – Early Trials
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erlotinib Resistant: C3 – Early Trials
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KRAS G12C
|
Gastrointestinal Cancer
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KRAS G12C
|
Gastrointestinal Cancer
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sotorasib + AbGn-107 Sensitive: C3 – Early Trials
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sotorasib + AbGn-107 Sensitive: C3 – Early Trials
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KRAS G12C
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NSCLC
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KRAS G12C
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NSCLC
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sotorasib + VS-6766 Sensitive: C3 – Early Trials
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sotorasib + VS-6766 Sensitive: C3 – Early Trials
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KRAS G12C
|
CRC
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KRAS G12C
|
CRC
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panitumumab + sotorasib Sensitive: C3 – Early Trials
|
panitumumab + sotorasib Sensitive: C3 – Early Trials
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KRAS G12C
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NSCLC
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KRAS G12C
|
NSCLC
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lorlatinib Resistant: C3 – Early Trials
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lorlatinib Resistant: C3 – Early Trials
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KRAS G12C
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CRC
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KRAS G12C
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CRC
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bevacizumab Resistant: C3 – Early Trials
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bevacizumab Resistant: C3 – Early Trials
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KRAS G12C
|
NSCLC
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KRAS G12C
|
NSCLC
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toripalimab Sensitive: C3 – Early Trials
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toripalimab Sensitive: C3 – Early Trials
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KRAS G12C
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Pancreatic Ductal Adenocarcinoma
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KRAS G12C
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Pancreatic Ductal Adenocarcinoma
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MRTX849 Sensitive: C3 – Early Trials
|
MRTX849 Sensitive: C3 – Early Trials
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KRAS G12C
|
NSCLC
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KRAS G12C
|
NSCLC
|
Immunotherapy Sensitive: C3 – Early Trials
|
Immunotherapy Sensitive: C3 – Early Trials
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KRAS G12C
|
NSCLC
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KRAS G12C
|
NSCLC
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docetaxel Resistant: C3 – Early Trials
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docetaxel Resistant: C3 – Early Trials
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KRAS G12C
|
NSCLC
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KRAS G12C
|
NSCLC
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crizotinib Resistant: C4 – Case Studies
|
crizotinib Resistant: C4 – Case Studies
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KRAS G12C
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LUAD
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KRAS G12C
|
LUAD
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MRTX849 + TVB-3664 Sensitive: D – Preclinical
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MRTX849 + TVB-3664 Sensitive: D – Preclinical
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KRAS G12C
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Pancreatic Cancer
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KRAS G12C
|
Pancreatic Cancer
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sotorasib + VRx-510 Sensitive: D – Preclinical
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sotorasib + VRx-510 Sensitive: D – Preclinical
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KRAS G12C
|
NSCLC
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KRAS G12C
|
NSCLC
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sotorasib + VRx-510 Sensitive: D – Preclinical
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sotorasib + VRx-510 Sensitive: D – Preclinical
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KRAS G12C
|
NSCLC
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KRAS G12C
|
NSCLC
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sotorasib + TPX-0005 Sensitive: D – Preclinical
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sotorasib + TPX-0005 Sensitive: D – Preclinical
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KRAS G12C
|
Solid Tumor
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KRAS G12C
|
Solid Tumor
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sotorasib + IN10018 Sensitive: D – Preclinical
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sotorasib + IN10018 Sensitive: D – Preclinical
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KRAS G12C
|
Solid Tumor
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KRAS G12C
|
Solid Tumor
|
PD-0325901 + BGB-283 Sensitive: D – Preclinical
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PD-0325901 + BGB-283 Sensitive: D – Preclinical
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KRAS G12C
|
CRC
|
KRAS G12C
|
CRC
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regorafenib Resistant: D – Preclinical
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regorafenib Resistant: D – Preclinical
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KRAS G12C
|
CRC
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KRAS G12C
|
CRC
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sunitinib Resistant: D – Preclinical
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sunitinib Resistant: D – Preclinical
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KRAS G12C
|
NSCLC
|
KRAS G12C
|
NSCLC
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sotorasib + VS-6766 + MRTX849 Sensitive: D – Preclinical
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sotorasib + VS-6766 + MRTX849 Sensitive: D – Preclinical
|
KRAS G12C
|
CRC
|
KRAS G12C
|
CRC
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sotorasib + VS-6766 + MRTX849 Sensitive: D – Preclinical
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sotorasib + VS-6766 + MRTX849 Sensitive: D – Preclinical
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KRAS G12C
|
NSCLC
|
KRAS G12C
|
NSCLC
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sotorasib + VS-6766 + VS-6063 Sensitive: D – Preclinical
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sotorasib + VS-6766 + VS-6063 Sensitive: D – Preclinical
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KRAS G12C
|
NSCLC
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KRAS G12C
|
NSCLC
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selinexor + MRTX1257 Sensitive: D – Preclinical
|
selinexor + MRTX1257 Sensitive: D – Preclinical
|
KRAS G12C
|
Lung Cancer
|
KRAS G12C
|
Lung Cancer
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afatinib + sotorasib Sensitive: D – Preclinical
|
afatinib + sotorasib Sensitive: D – Preclinical
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KRAS G12C
|
Lung Cancer
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KRAS G12C
|
Lung Cancer
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sotorasib + RMC-4550 Sensitive: D – Preclinical
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sotorasib + RMC-4550 Sensitive: D – Preclinical
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KRAS G12C
|
Lung Cancer
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KRAS G12C
|
Lung Cancer
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palbociclib + sotorasib Sensitive: D – Preclinical
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palbociclib + sotorasib Sensitive: D – Preclinical
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KRAS G12C
|
CRC
|
KRAS G12C
|
CRC
|
D-1553 Sensitive: D – Preclinical
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D-1553 Sensitive: D – Preclinical
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KRAS G12C
|
NSCLC
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KRAS G12C
|
NSCLC
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sotorasib + selinexor Sensitive: D – Preclinical
|
sotorasib + selinexor Sensitive: D – Preclinical
|
KRAS G12C
|
Pancreatic Ductal Adenocarcinoma
|
KRAS G12C
|
Pancreatic Ductal Adenocarcinoma
|
sotorasib + selinexor Sensitive: D – Preclinical
|
sotorasib + selinexor Sensitive: D – Preclinical
|
KRAS G12C
|
Pancreatic Ductal Adenocarcinoma
|
KRAS G12C
|
Pancreatic Ductal Adenocarcinoma
|
selinexor + MRTX1257 Sensitive: D – Preclinical
|
selinexor + MRTX1257 Sensitive: D – Preclinical
|
KRAS G12C
|
Pancreatic Cancer
|
KRAS G12C
|
Pancreatic Cancer
|
D-1553 Sensitive: D – Preclinical
|
D-1553 Sensitive: D – Preclinical
|
KRAS G12C
|
CRC
|
KRAS G12C
|
CRC
|
trametinib + panitumumab + sotorasib Sensitive: D – Preclinical
|
trametinib + panitumumab + sotorasib Sensitive: D – Preclinical
|
KRAS G12C
|
CRC
|
KRAS G12C
|
CRC
|
trametinib + sotorasib Sensitive: D – Preclinical
|
trametinib + sotorasib Sensitive: D – Preclinical
|
KRAS G12C
|
Pancreatic Adenocarcinoma
|
KRAS G12C
|
Pancreatic Adenocarcinoma
|
ASN007 Sensitive: D – Preclinical
|
ASN007 Sensitive: D – Preclinical
|
KRAS G12C
|
CRC
|
KRAS G12C
|
CRC
|
sotorasib + DT2216 Sensitive: D – Preclinical
|
sotorasib + DT2216 Sensitive: D – Preclinical
|
KRAS G12C
|
NSCLC
|
KRAS G12C
|
NSCLC
|
sotorasib + DT2216 Sensitive: D – Preclinical
|
sotorasib + DT2216 Sensitive: D – Preclinical
|
KRAS G12C
|
NSCLC
|
KRAS G12C
|
NSCLC
|
APG-1842 Sensitive: D – Preclinical
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APG-1842 Sensitive: D – Preclinical
|
KRAS G12C
|
CRC
|
KRAS G12C
|
CRC
|
APG-1842 Sensitive: D – Preclinical
|
APG-1842 Sensitive: D – Preclinical
|
KRAS G12C
|
Gastric Cancer
|
KRAS G12C
|
Gastric Cancer
|
APG-1842 Sensitive: D – Preclinical
|
APG-1842 Sensitive: D – Preclinical
|
KRAS G12C
|
NSCLC
|
KRAS G12C
|
NSCLC
|
sotorasib + DCC-3116 Sensitive: D – Preclinical
|
sotorasib + DCC-3116 Sensitive: D – Preclinical
|
KRAS G12C
|
CRC
|
KRAS G12C
|
CRC
|
BMF-219 Sensitive: D – Preclinical
|
BMF-219 Sensitive: D – Preclinical
|
KRAS G12C
|
Lung Cancer
|
KRAS G12C
|
Lung Cancer
|
BMF-219 Sensitive: D – Preclinical
|
BMF-219 Sensitive: D – Preclinical
|
KRAS G12C
|
LUAD
|
KRAS G12C
|
LUAD
|
TTI-101 oral Sensitive: D – Preclinical
|
TTI-101 oral Sensitive: D – Preclinical
|
KRAS G12C
|
Solid Tumor
|
KRAS G12C
|
Solid Tumor
|
JDQ443 + TNO155 Sensitive: D – Preclinical
|
JDQ443 + TNO155 Sensitive: D – Preclinical
|
KRAS G12C
|
Pancreatic Cancer
|
KRAS G12C
|
Pancreatic Cancer
|
sotorasib + DT2216 Sensitive: D – Preclinical
|
sotorasib + DT2216 Sensitive: D – Preclinical
|
KRAS G12C
|
Pancreatic Cancer
|
KRAS G12C
|
Pancreatic Cancer
|
sotorasib + IMM-1-104 Sensitive: D – Preclinical
|
sotorasib + IMM-1-104 Sensitive: D – Preclinical
|
