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BIOMARKER:
KIAA1549-BRAF fusion
i
Other names:
KIAA1549, UPF0606 Protein KIAA1549, RP86, BRAF, B-raf proto-oncogene, B-raf proto-oncogene, Serine/threonine kinase, V-Raf murine sarcoma viral oncogene homolog B, Serine/threonine-protein kinase B-Raf, Proto-oncogene B-Raf, BRAF1, RAFB1, B-raf proto-oncogene Serine/threonine-protein kinase, Murine sarcoma viral (V-Raf) oncogene homolog B1, B-raf serine/threonine-protein, 94 KDa B-raf protein, B-RAF1
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Entrez ID:
673
;
57670
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
BRAF V600E (255)
BRAF mutation (129)
BRAF V600 (106)
BRAF V600K (25)
BRAF wild-type (25)
BRAF G469V (7)
BRAF K601E (7)
RAS wild-type + BRAF wild-type (7)
BRAF D594G (6)
BRAF V600E + RNF43 mutation (6)
EGFR mutation + BRAF V600E (6)
BRAF G466V (4)
BRAF V600E + PIK3CA mutation (4)
BRAF V600G (4)
NRAS mutation + BRAF mutation (4)
BRAF D549G (3)
BRAF G469A (3)
BRAF G469E (3)
BRAF L597Q (3)
BRAF L597R (3)
BRAF T1799A (3)
BRAF V595E (3)
BRAF V600E + TERT mutation (3)
BRAF V600R (3)
BRAF delNVTAP (3)
NRAS Q61K + BRAF V600E (3)
TERT mutation + BRAF V600E (3)
BRAF G466A (2)
BRAF L485W (2)
BRAF V600D (2)
BRAF V600E + MAP2K1 I111S (2)
BRAF V600M (2)
BRAF mutation + MEK1 P124L (2)
BRAF mutation + NF1 mutation (2)
BRAF rearrangement (2)
EGFR mutation + BRAF V600 (2)
IDH1 wild-type + BRAF mutation (2)
KRAS G13D + BRAF mutation (2)
MYD88 L265P + BRAF V600E (2)
NRAS G12C + BRAF mutation (2)
AKT1 E17K + BRAF V600 (1)
BRAF 486_490 del (1)
BRAF D594N (1)
BRAF G464 (1)
BRAF G464E (1)
BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)
BRAF G466V + KIT K509Q (1)
BRAF G469R (1)
BRAF G469S (1)
BRAF G596V (1)
BRAF L505H (1)
BRAF L597K (1)
BRAF L597S (1)
BRAF N486-P490del + TP53 V157G (1)
BRAF S365L (1)
BRAF T599 (1)
BRAF V600 wild-type (1)
BRAF V600DK601del (1)
BRAF V600E + BRAF G469A + BRAF G469V (1)
BRAF V600E + BRAF K601_W604del (1)
BRAF V600E + BRAF L514V (1)
BRAF V600E + BRAF V600K (1)
BRAF V600E + KRAS G12R (1)
BRAF V600E + MSI-H/dMMR (1)
BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)
BRAF V600_K601delinsE (1)
BRAF Y472C (1)
BRAF mutation + EGFR mutation (1)
BRAF mutation + MAP2K1 mutation (1)
BRAF mutation + RAS mutation (1)
BRAF mutation + TERT −124C>T (1)
BRAF mutation + TERT −138CC>TT (1)
BRAF mutation + TERT −139CC>TT (1)
BRAF mutation + TERT −146C>T (1)
BRAF mutation + TET2 mutation (1)
BRAF mutation + TP53 mutation (1)
BRAF wild-type + NRAS wild-type (1)
EGFR T790M + BRAF V600E (1)
EGFR exon 19 deletion + BRAF V600E (1)
EGFR mutation + BRAF G469A (1)
EGFR mutation + BRAF mutation + TP53 mutation (1)
KRAS G12A + BRAF D549N (1)
KRAS G12V + BRAF V600E (1)
MAP2K1 V211D + BRAF mutation (1)
NRAS G12C + BRAF V600E + BRAF V600D (1)
NRAS G13D + BRAF V600E (1)
RAS wild-type + BRAF wild-type + MAP2K1 N57K (1)
ROS1 rearrangement + BRAF V600E (1)
TERT promoter mutation + BRAF V600 (1)
BRAF K601 (0)
BRAF L597 (0)
BRAF V600E + TERT mutation (0)
BRAF V600E + KRAS G12D (0)
BRAF V600E + MAP2K1 P124S (0)
BRAF exon 11 mutation (0)
BRAF exon 15 mutation (0)
CDKN2A mutation + BRAF V600E (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
BRAF V600E (255)
BRAF mutation (129)
BRAF V600 (106)
BRAF V600K (25)
BRAF wild-type (25)
BRAF G469V (7)
BRAF K601E (7)
RAS wild-type + BRAF wild-type (7)
BRAF D594G (6)
BRAF V600E + RNF43 mutation (6)
EGFR mutation + BRAF V600E (6)
BRAF G466V (4)
BRAF V600E + PIK3CA mutation (4)
BRAF V600G (4)
NRAS mutation + BRAF mutation (4)
BRAF D549G (3)
BRAF G469A (3)
BRAF G469E (3)
BRAF L597Q (3)
BRAF L597R (3)
BRAF T1799A (3)
BRAF V595E (3)
BRAF V600E + TERT mutation (3)
BRAF V600R (3)
BRAF delNVTAP (3)
NRAS Q61K + BRAF V600E (3)
TERT mutation + BRAF V600E (3)
BRAF G466A (2)
BRAF L485W (2)
BRAF V600D (2)
BRAF V600E + MAP2K1 I111S (2)
BRAF V600M (2)
BRAF mutation + MEK1 P124L (2)
BRAF mutation + NF1 mutation (2)
BRAF rearrangement (2)
EGFR mutation + BRAF V600 (2)
IDH1 wild-type + BRAF mutation (2)
KRAS G13D + BRAF mutation (2)
MYD88 L265P + BRAF V600E (2)
NRAS G12C + BRAF mutation (2)
AKT1 E17K + BRAF V600 (1)
BRAF 486_490 del (1)
BRAF D594N (1)
BRAF G464 (1)
BRAF G464E (1)
BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)
BRAF G466V + KIT K509Q (1)
BRAF G469R (1)
BRAF G469S (1)
BRAF G596V (1)
BRAF L505H (1)
BRAF L597K (1)
BRAF L597S (1)
BRAF N486-P490del + TP53 V157G (1)
BRAF S365L (1)
BRAF T599 (1)
BRAF V600 wild-type (1)
BRAF V600DK601del (1)
BRAF V600E + BRAF G469A + BRAF G469V (1)
BRAF V600E + BRAF K601_W604del (1)
BRAF V600E + BRAF L514V (1)
BRAF V600E + BRAF V600K (1)
BRAF V600E + KRAS G12R (1)
BRAF V600E + MSI-H/dMMR (1)
BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)
BRAF V600_K601delinsE (1)
BRAF Y472C (1)
BRAF mutation + EGFR mutation (1)
BRAF mutation + MAP2K1 mutation (1)
BRAF mutation + RAS mutation (1)
BRAF mutation + TERT −124C>T (1)
BRAF mutation + TERT −138CC>TT (1)
BRAF mutation + TERT −139CC>TT (1)
BRAF mutation + TERT −146C>T (1)
BRAF mutation + TET2 mutation (1)
BRAF mutation + TP53 mutation (1)
BRAF wild-type + NRAS wild-type (1)
EGFR T790M + BRAF V600E (1)
EGFR exon 19 deletion + BRAF V600E (1)
EGFR mutation + BRAF G469A (1)
EGFR mutation + BRAF mutation + TP53 mutation (1)
KRAS G12A + BRAF D549N (1)
KRAS G12V + BRAF V600E (1)
MAP2K1 V211D + BRAF mutation (1)
NRAS G12C + BRAF V600E + BRAF V600D (1)
NRAS G13D + BRAF V600E (1)
RAS wild-type + BRAF wild-type + MAP2K1 N57K (1)
ROS1 rearrangement + BRAF V600E (1)
TERT promoter mutation + BRAF V600 (1)
BRAF K601 (0)
BRAF L597 (0)
BRAF V600E + TERT mutation (0)
BRAF V600E + KRAS G12D (0)
BRAF V600E + MAP2K1 P124S (0)
BRAF exon 11 mutation (0)
BRAF exon 15 mutation (0)
CDKN2A mutation + BRAF V600E (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
›
Associations
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Trials
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KIAA1549-BRAF fusion
Astrocytoma
KIAA1549-BRAF fusion
Astrocytoma
selumetinib
Sensitive: C2 – Inclusion Criteria
selumetinib
Sensitive
:
C2
selumetinib
Sensitive: C2 – Inclusion Criteria
selumetinib
Sensitive
:
C2
KIAA1549-BRAF fusion
Glioma
KIAA1549-BRAF fusion
Glioma
trametinib
Sensitive: C2 – Inclusion Criteria
trametinib
Sensitive
:
C2
trametinib
Sensitive: C2 – Inclusion Criteria
trametinib
Sensitive
:
C2
KIAA1549-BRAF fusion
Glioma
KIAA1549-BRAF fusion
Glioma
selumetinib
Sensitive: C2 – Inclusion Criteria
selumetinib
Sensitive
:
C2
selumetinib
Sensitive: C2 – Inclusion Criteria
selumetinib
Sensitive
:
C2
KIAA1549-BRAF fusion
Soft Tissue Sarcoma
KIAA1549-BRAF fusion
Soft Tissue Sarcoma
bevacizumab + sorafenib + temsirolimus
Sensitive: C3 – Early Trials
bevacizumab + sorafenib + temsirolimus
Sensitive
:
C3
bevacizumab + sorafenib + temsirolimus
Sensitive: C3 – Early Trials
bevacizumab + sorafenib + temsirolimus
Sensitive
:
C3
KIAA1549-BRAF fusion
Glioma
KIAA1549-BRAF fusion
Glioma
FCN-159
Sensitive: C3 – Early Trials
FCN-159
Sensitive
:
C3
FCN-159
Sensitive: C3 – Early Trials
FCN-159
Sensitive
:
C3
KIAA1549-BRAF fusion
Melanoma
KIAA1549-BRAF fusion
Melanoma
trametinib
Sensitive: C4 – Case Studies
trametinib
Sensitive
:
C4
trametinib
Sensitive: C4 – Case Studies
trametinib
Sensitive
:
C4
KIAA1549-BRAF fusion
Melanoma
KIAA1549-BRAF fusion
Melanoma
fotemustine
Sensitive: C4 – Case Studies
fotemustine
Sensitive
:
C4
fotemustine
Sensitive: C4 – Case Studies
fotemustine
Sensitive
:
C4
KIAA1549-BRAF fusion
Melanoma
KIAA1549-BRAF fusion
Melanoma
bevacizumab + sorafenib + temsirolimus
Sensitive: C4 – Case Studies
bevacizumab + sorafenib + temsirolimus
Sensitive
:
C4
bevacizumab + sorafenib + temsirolimus
Sensitive: C4 – Case Studies
bevacizumab + sorafenib + temsirolimus
Sensitive
:
C4
KIAA1549-BRAF fusion
Melanoma
KIAA1549-BRAF fusion
Melanoma
pembrolizumab
Sensitive: C4 – Case Studies
pembrolizumab
Sensitive
:
C4
pembrolizumab
Sensitive: C4 – Case Studies
pembrolizumab
Sensitive
:
C4
KIAA1549-BRAF fusion
Glioma
KIAA1549-BRAF fusion
Glioma
BVD-523
Sensitive: D – Preclinical
BVD-523
Sensitive
:
D
BVD-523
Sensitive: D – Preclinical
BVD-523
Sensitive
:
D
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