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BIOMARKER:
EGFR mutation + TP53 mutation
i
Other names:
EGFR, ERBB, ERBB1, Epidermal growth factor receptor, TP53, Tumor Protein P53, Cellular Tumor Antigen P53, Phosphoprotein P53, Tumor Protein P53, Antigen NY-CO-13, Transformation-Related Protein 53, Mutant Tumor Protein 53, P53 Tumor Suppressor, Tumor Suppressor P53, Tumor Protein 53, BMFS5, TRP53, BCC7, LFS1
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Entrez ID:
1956
;
7157
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
EGFR exon 19 deletion (79)
EGFR amplification (52)
TP53 deletion (21)
EGFR exon 18 deletion (3)
EGFR exon 2-7 deletion + EGFR amplification (2)
EGFR amplification + ERBB2 amplification (1)
EGFR exon 19 deletion + HER-2 amplification (1)
EGFR exon 21 deletion (1)
LPL deletion + TP53 deletion (1)
TP53 amplification (1)
EGFR T790M + exon 19 deletion (0)
EGFR amplifcation (0)
EGFR exon 19 deletion (79)
EGFR amplification (52)
TP53 deletion (21)
EGFR exon 18 deletion (3)
EGFR exon 2-7 deletion + EGFR amplification (2)
EGFR amplification + ERBB2 amplification (1)
EGFR exon 19 deletion + HER-2 amplification (1)
EGFR exon 21 deletion (1)
LPL deletion + TP53 deletion (1)
TP53 amplification (1)
EGFR T790M + exon 19 deletion (0)
EGFR amplifcation (0)
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Trials
VERI cancer hierarchy
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EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR inhibitor
Resistant: B - Late Trials
EGFR inhibitor
Resistant
:
B
EGFR inhibitor
Resistant: B - Late Trials
EGFR inhibitor
Resistant
:
B
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
osimertinib
Resistant: C3 – Early Trials
osimertinib
Resistant
:
C3
osimertinib
Resistant: C3 – Early Trials
osimertinib
Resistant
:
C3
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
EGFR mutation + TP53 mutation
Lung Adenocarcinoma
EGFR mutation + TP53 mutation
Lung Adenocarcinoma
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
EGFR mutation + TP53 mutation
Pancreatic Cancer
EGFR mutation + TP53 mutation
Pancreatic Cancer
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
aumolertinib
Sensitive: C3 – Early Trials
aumolertinib
Sensitive
:
C3
aumolertinib
Sensitive: C3 – Early Trials
aumolertinib
Sensitive
:
C3
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR inhibitor + Angiogenesis inhibitor
Sensitive: C3 – Early Trials
EGFR inhibitor + Angiogenesis inhibitor
Sensitive
:
C3
EGFR inhibitor + Angiogenesis inhibitor
Sensitive: C3 – Early Trials
EGFR inhibitor + Angiogenesis inhibitor
Sensitive
:
C3
EGFR mutation + TP53 mutation
Lung Cancer
EGFR mutation + TP53 mutation
Lung Cancer
osimertinib
Resistant: C3 – Early Trials
osimertinib
Resistant
:
C3
osimertinib
Resistant: C3 – Early Trials
osimertinib
Resistant
:
C3
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
EGFR mutation + TP53 mutation
Lung Adenocarcinoma
EGFR mutation + TP53 mutation
Lung Adenocarcinoma
EGFR inhibitor
Resistant: C3 – Early Trials
EGFR inhibitor
Resistant
:
C3
EGFR inhibitor
Resistant: C3 – Early Trials
EGFR inhibitor
Resistant
:
C3
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
bevacizumab + aumolertinib
Sensitive: C3 – Early Trials
bevacizumab + aumolertinib
Sensitive
:
C3
bevacizumab + aumolertinib
Sensitive: C3 – Early Trials
bevacizumab + aumolertinib
Sensitive
:
C3
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