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BIOMARKER:
TP53 deletion
i
Other names:
TP53, Tumor Protein P53, Cellular Tumor Antigen P53, Phosphoprotein P53, Tumor Protein P53, Antigen NY-CO-13, Transformation-Related Protein 53, Mutant Tumor Protein 53, P53 Tumor Suppressor, Tumor Suppressor P53, Tumor Protein 53, BMFS5, TRP53, BCC7, LFS1
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Entrez ID:
7157
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
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TP53 deletion
Chronic Lymphocytic Leukemia
TP53 deletion
Chronic Lymphocytic Leukemia
idelalisib
Sensitive: A2 - Guideline
idelalisib
Sensitive
:
A2
idelalisib
Sensitive: A2 - Guideline
idelalisib
Sensitive
:
A2
TP53 deletion
Chronic Lymphocytic Leukemia
TP53 deletion
Chronic Lymphocytic Leukemia
ibrutinib
Sensitive: A2 - Guideline
ibrutinib
Sensitive
:
A2
ibrutinib
Sensitive: A2 - Guideline
ibrutinib
Sensitive
:
A2
TP53 deletion
Chronic Lymphocytic Leukemia
TP53 deletion
Chronic Lymphocytic Leukemia
rituximab
Sensitive: A2 - Guideline
rituximab
Sensitive
:
A2
rituximab
Sensitive: A2 - Guideline
rituximab
Sensitive
:
A2
TP53 deletion
Small Lymphocytic Lymphoma
TP53 deletion
Small Lymphocytic Lymphoma
ibrutinib
Sensitive: A2 - Guideline
ibrutinib
Sensitive
:
A2
ibrutinib
Sensitive: A2 - Guideline
ibrutinib
Sensitive
:
A2
TP53 deletion
Prostate Cancer
TP53 deletion
Prostate Cancer
abiraterone acetate
Resistant: B - Late Trials
abiraterone acetate
Resistant
:
B
abiraterone acetate
Resistant: B - Late Trials
abiraterone acetate
Resistant
:
B
TP53 deletion
Prostate Cancer
TP53 deletion
Prostate Cancer
enzalutamide capsule
Resistant: B - Late Trials
enzalutamide capsule
Resistant
:
B
enzalutamide capsule
Resistant: B - Late Trials
enzalutamide capsule
Resistant
:
B
TP53 deletion
Chronic Lymphocytic Leukemia
TP53 deletion
Chronic Lymphocytic Leukemia
venetoclax + obinutuzumab
Sensitive: C2 – Inclusion Criteria
venetoclax + obinutuzumab
Sensitive
:
C2
venetoclax + obinutuzumab
Sensitive: C2 – Inclusion Criteria
venetoclax + obinutuzumab
Sensitive
:
C2
TP53 deletion
Melanoma
TP53 deletion
Melanoma
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
TP53 deletion
B Acute Lymphoblastic Leukemia
TP53 deletion
B Acute Lymphoblastic Leukemia
inotuzumab ozogamicin
Sensitive: C3 – Early Trials
inotuzumab ozogamicin
Sensitive
:
C3
inotuzumab ozogamicin
Sensitive: C3 – Early Trials
inotuzumab ozogamicin
Sensitive
:
C3
TP53 deletion
Mantle Cell Lymphoma
TP53 deletion
Mantle Cell Lymphoma
venetoclax + ibrutinib + rituximab
Sensitive: C3 – Early Trials
venetoclax + ibrutinib + rituximab
Sensitive
:
C3
venetoclax + ibrutinib + rituximab
Sensitive: C3 – Early Trials
venetoclax + ibrutinib + rituximab
Sensitive
:
C3
TP53 deletion
Peripheral T-cell Lymphoma
TP53 deletion
Peripheral T-cell Lymphoma
Resistant: C3 – Early Trials
Resistant
:
C3
Resistant: C3 – Early Trials
Resistant
:
C3
TP53 deletion
Diffuse Large B Cell Lymphoma
TP53 deletion
Diffuse Large B Cell Lymphoma
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
TP53 deletion
Marginal Zone Lymphoma
TP53 deletion
Marginal Zone Lymphoma
ibrutinib
Resistant: C3 – Early Trials
ibrutinib
Resistant
:
C3
ibrutinib
Resistant: C3 – Early Trials
ibrutinib
Resistant
:
C3
TP53 deletion
Chronic Lymphocytic Leukemia
TP53 deletion
Chronic Lymphocytic Leukemia
ONC212
Sensitive: D – Preclinical
ONC212
Sensitive
:
D
ONC212
Sensitive: D – Preclinical
ONC212
Sensitive
:
D
TP53 deletion
Colorectal Cancer
TP53 deletion
Colorectal Cancer
sirolimus + IPI-504
Sensitive: D – Preclinical
sirolimus + IPI-504
Sensitive
:
D
sirolimus + IPI-504
Sensitive: D – Preclinical
sirolimus + IPI-504
Sensitive
:
D
TP53 deletion
Non Small Cell Lung Cancer
TP53 deletion
Non Small Cell Lung Cancer
sirolimus + IPI-504
Sensitive: D – Preclinical
sirolimus + IPI-504
Sensitive
:
D
sirolimus + IPI-504
Sensitive: D – Preclinical
sirolimus + IPI-504
Sensitive
:
D
TP53 deletion
Mantle Cell Lymphoma
TP53 deletion
Mantle Cell Lymphoma
venetoclax
Resistant: D – Preclinical
venetoclax
Resistant
:
D
venetoclax
Resistant: D – Preclinical
venetoclax
Resistant
:
D
TP53 deletion
B Acute Lymphoblastic Leukemia
TP53 deletion
B Acute Lymphoblastic Leukemia
romidepsin
Sensitive: D – Preclinical
romidepsin
Sensitive
:
D
romidepsin
Sensitive: D – Preclinical
romidepsin
Sensitive
:
D
TP53 deletion
Lymphoma
TP53 deletion
Lymphoma
crizotinib
Resistant: D – Preclinical
crizotinib
Resistant
:
D
crizotinib
Resistant: D – Preclinical
crizotinib
Resistant
:
D
TP53 deletion
Lymphoma
TP53 deletion
Lymphoma
brigatinib
Sensitive: D – Preclinical
brigatinib
Sensitive
:
D
brigatinib
Sensitive: D – Preclinical
brigatinib
Sensitive
:
D
TP53 deletion
Acute Lymphocytic Leukemia
TP53 deletion
Acute Lymphocytic Leukemia
M6620 + BAY2402234
Sensitive: D – Preclinical
M6620 + BAY2402234
Sensitive
:
D
M6620 + BAY2402234
Sensitive: D – Preclinical
M6620 + BAY2402234
Sensitive
:
D
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