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BIOMARKER:
EGFR amplification
i
Other names:
EGFR, ERBB, ERBB1, Epidermal growth factor receptor
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Entrez ID:
1956
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
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EGFR amplification
Non Small Cell Lung Cancer
EGFR amplification
Non Small Cell Lung Cancer
gefitinib
Sensitive: B - Late Trials
gefitinib
Sensitive
:
B
gefitinib
Sensitive: B - Late Trials
gefitinib
Sensitive
:
B
EGFR amplification
Squamous Cell Carcinoma of Head and Neck
EGFR amplification
Squamous Cell Carcinoma of Head and Neck
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
EGFR amplification
Non Small Cell Lung Cancer
EGFR amplification
Non Small Cell Lung Cancer
erlotinib
Sensitive: C2 – Inclusion Criteria
erlotinib
Sensitive
:
C2
erlotinib
Sensitive: C2 – Inclusion Criteria
erlotinib
Sensitive
:
C2
EGFR amplification
Glioblastoma
EGFR amplification
Glioblastoma
ABT-414
Sensitive: C2 – Inclusion Criteria
ABT-414
Sensitive
:
C2
ABT-414
Sensitive: C2 – Inclusion Criteria
ABT-414
Sensitive
:
C2
EGFR amplification
Glioblastoma
EGFR amplification
Glioblastoma
lapatinib
Sensitive: C2 – Inclusion Criteria
lapatinib
Sensitive
:
C2
lapatinib
Sensitive: C2 – Inclusion Criteria
lapatinib
Sensitive
:
C2
EGFR amplification
Esophageal Squamous Cell Carcinoma
EGFR amplification
Esophageal Squamous Cell Carcinoma
afatinib
Sensitive: C2 – Inclusion Criteria
afatinib
Sensitive
:
C2
afatinib
Sensitive: C2 – Inclusion Criteria
afatinib
Sensitive
:
C2
EGFR amplification
Glioblastoma
EGFR amplification
Glioblastoma
KD019
Sensitive: C2 – Inclusion Criteria
KD019
Sensitive
:
C2
KD019
Sensitive: C2 – Inclusion Criteria
KD019
Sensitive
:
C2
EGFR amplification
Glioma
EGFR amplification
Glioma
ABT-414
Sensitive: C2 – Inclusion Criteria
ABT-414
Sensitive
:
C2
ABT-414
Sensitive: C2 – Inclusion Criteria
ABT-414
Sensitive
:
C2
EGFR amplification
Glioblastoma
EGFR amplification
Glioblastoma
bevacizumab
Sensitive: C2 – Inclusion Criteria
bevacizumab
Sensitive
:
C2
bevacizumab
Sensitive: C2 – Inclusion Criteria
bevacizumab
Sensitive
:
C2
EGFR amplification
Squamous Cell Carcinoma of Head and Neck
EGFR amplification
Squamous Cell Carcinoma of Head and Neck
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
EGFR amplification
Gastric Cancer
EGFR amplification
Gastric Cancer
cetuximab
Sensitive: C3 – Early Trials
cetuximab
Sensitive
:
C3
cetuximab
Sensitive: C3 – Early Trials
cetuximab
Sensitive
:
C3
EGFR amplification
Glioblastoma
EGFR amplification
Glioblastoma
erlotinib
Resistant: C3 – Early Trials
erlotinib
Resistant
:
C3
erlotinib
Resistant: C3 – Early Trials
erlotinib
Resistant
:
C3
EGFR amplification
Melanoma
EGFR amplification
Melanoma
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
EGFR amplification
Mucosal Melanoma
EGFR amplification
Mucosal Melanoma
ipilimumab
Resistant: C3 – Early Trials
ipilimumab
Resistant
:
C3
ipilimumab
Resistant: C3 – Early Trials
ipilimumab
Resistant
:
C3
EGFR amplification
Mucosal Melanoma
EGFR amplification
Mucosal Melanoma
nivolumab
Resistant: C3 – Early Trials
nivolumab
Resistant
:
C3
nivolumab
Resistant: C3 – Early Trials
nivolumab
Resistant
:
C3
EGFR amplification
Mucosal Melanoma
EGFR amplification
Mucosal Melanoma
nivolumab + ipilimumab
Resistant: C3 – Early Trials
nivolumab + ipilimumab
Resistant
:
C3
nivolumab + ipilimumab
Resistant: C3 – Early Trials
nivolumab + ipilimumab
Resistant
:
C3
EGFR amplification
Mucosal Melanoma
EGFR amplification
Mucosal Melanoma
pembrolizumab
Resistant: C3 – Early Trials
pembrolizumab
Resistant
:
C3
pembrolizumab
Resistant: C3 – Early Trials
pembrolizumab
Resistant
:
C3
EGFR amplification
Colorectal Cancer
EGFR amplification
Colorectal Cancer
cetuximab
Resistant: C3 – Early Trials
cetuximab
Resistant
:
C3
cetuximab
Resistant: C3 – Early Trials
cetuximab
Resistant
:
C3
EGFR amplification
Colorectal Cancer
EGFR amplification
Colorectal Cancer
panitumumab
Sensitive: C3 – Early Trials
panitumumab
Sensitive
:
C3
panitumumab
Sensitive: C3 – Early Trials
panitumumab
Sensitive
:
C3
EGFR amplification
Non Small Cell Lung Cancer
EGFR amplification
Non Small Cell Lung Cancer
osimertinib
Resistant: C3 – Early Trials
osimertinib
Resistant
:
C3
osimertinib
Resistant: C3 – Early Trials
osimertinib
Resistant
:
C3
EGFR amplification
Solid Tumor
EGFR amplification
Solid Tumor
ABSK091
Sensitive: C3 – Early Trials
ABSK091
Sensitive
:
C3
ABSK091
Sensitive: C3 – Early Trials
ABSK091
Sensitive
:
C3
EGFR amplification
Lung Cancer
EGFR amplification
Lung Cancer
gefitinib
Resistant: C3 – Early Trials
gefitinib
Resistant
:
C3
gefitinib
Resistant: C3 – Early Trials
gefitinib
Resistant
:
C3
EGFR amplification
Lung Cancer
EGFR amplification
Lung Cancer
icotinib
Resistant: C3 – Early Trials
icotinib
Resistant
:
C3
icotinib
Resistant: C3 – Early Trials
icotinib
Resistant
:
C3
EGFR amplification
Non Small Cell Lung Cancer
EGFR amplification
Non Small Cell Lung Cancer
bevacizumab + erlotinib
Sensitive: C3 – Early Trials
bevacizumab + erlotinib
Sensitive
:
C3
bevacizumab + erlotinib
Sensitive: C3 – Early Trials
bevacizumab + erlotinib
Sensitive
:
C3
EGFR amplification
Non Small Cell Lung Cancer
EGFR amplification
Non Small Cell Lung Cancer
bevacizumab + gefitinib
Sensitive: C3 – Early Trials
bevacizumab + gefitinib
Sensitive
:
C3
bevacizumab + gefitinib
Sensitive: C3 – Early Trials
bevacizumab + gefitinib
Sensitive
:
C3
EGFR amplification
Squamous Cell Carcinoma of Head and Neck
EGFR amplification
Squamous Cell Carcinoma of Head and Neck
pembrolizumab + afatinib
Sensitive: C3 – Early Trials
pembrolizumab + afatinib
Sensitive
:
C3
pembrolizumab + afatinib
Sensitive: C3 – Early Trials
pembrolizumab + afatinib
Sensitive
:
C3
EGFR amplification
Gastric Cancer
EGFR amplification
Gastric Cancer
EGFR inhibitor
Sensitive: C3 – Early Trials
EGFR inhibitor
Sensitive
:
C3
EGFR inhibitor
Sensitive: C3 – Early Trials
EGFR inhibitor
Sensitive
:
C3
EGFR amplification
Esophageal Cancer
EGFR amplification
Esophageal Cancer
EGFR inhibitor
Sensitive: C3 – Early Trials
EGFR inhibitor
Sensitive
:
C3
EGFR inhibitor
Sensitive: C3 – Early Trials
EGFR inhibitor
Sensitive
:
C3
EGFR amplification
Non Small Cell Lung Cancer
EGFR amplification
Non Small Cell Lung Cancer
KN046
Sensitive: C3 – Early Trials
KN046
Sensitive
:
C3
KN046
Sensitive: C3 – Early Trials
KN046
Sensitive
:
C3
EGFR amplification
Esophageal Squamous Cell Carcinoma
EGFR amplification
Esophageal Squamous Cell Carcinoma
Z650
Sensitive: C3 – Early Trials
Z650
Sensitive
:
C3
Z650
Sensitive: C3 – Early Trials
Z650
Sensitive
:
C3
EGFR amplification
Non Small Cell Lung Cancer
EGFR amplification
Non Small Cell Lung Cancer
afatinib
Resistant: C3 – Early Trials
afatinib
Resistant
:
C3
afatinib
Resistant: C3 – Early Trials
afatinib
Resistant
:
C3
EGFR amplification
Glioblastoma
EGFR amplification
Glioblastoma
nivolumab + bevacizumab
Resistant: C3 – Early Trials
nivolumab + bevacizumab
Resistant
:
C3
nivolumab + bevacizumab
Resistant: C3 – Early Trials
nivolumab + bevacizumab
Resistant
:
C3
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