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BIOMARKER:
EGFR mutation + TP53 mutation
i
Other names:
EGFR, ERBB, ERBB1, Epidermal growth factor receptor, TP53, Tumor Protein P53, Cellular Tumor Antigen P53, Phosphoprotein P53, Tumor Protein P53, Antigen NY-CO-13, Transformation-Related Protein 53, Mutant Tumor Protein 53, P53 Tumor Suppressor, Tumor Suppressor P53, Tumor Protein 53, BMFS5, TRP53, BCC7, LFS1
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Entrez ID:
1956
;
7157
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
EGFR expression (46)
EGFR overexpression (34)
EGFR positive (8)
EGFR negative (6)
EGFR negative + ALK negative (4)
TP53 expression (4)
TP53 overexpression (4)
EGFR expression + ALK positive (3)
EGFRVIII expression + PTEN expression (3)
EGFRvIII expression (3)
EGFR expression + MET expression (2)
EGFR overexpression + HER-2 overexpression (2)
MMP17 expression + EGFR expression + RB1 expression (2)
MUC1 expression + EGFR expression (2)
TROP2 expression + EGFR expression (2)
EGFR expression + HER-2 expression (1)
EGFR underexpression (1)
EGFRVIII overexpression (1)
EPHA2 overexpression + EGFR overexpression (1)
GPC3 positive + EGFR expression (1)
ROS1 positive + TP53 positive (1)
TP53 overexpression + CD5 overexpression (1)
DRD2 expression + EGFR overexpression (0)
YAP1 overexpression + EGFR overexpression (0)
EGFR expression (46)
EGFR overexpression (34)
EGFR positive (8)
EGFR negative (6)
EGFR negative + ALK negative (4)
TP53 expression (4)
TP53 overexpression (4)
EGFR expression + ALK positive (3)
EGFRVIII expression + PTEN expression (3)
EGFRvIII expression (3)
EGFR expression + MET expression (2)
EGFR overexpression + HER-2 overexpression (2)
MMP17 expression + EGFR expression + RB1 expression (2)
MUC1 expression + EGFR expression (2)
TROP2 expression + EGFR expression (2)
EGFR expression + HER-2 expression (1)
EGFR underexpression (1)
EGFRVIII overexpression (1)
EPHA2 overexpression + EGFR overexpression (1)
GPC3 positive + EGFR expression (1)
ROS1 positive + TP53 positive (1)
TP53 overexpression + CD5 overexpression (1)
DRD2 expression + EGFR overexpression (0)
YAP1 overexpression + EGFR overexpression (0)
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Associations
News
Trials
VERI cancer hierarchy
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EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR inhibitor
Resistant: B - Late Trials
EGFR inhibitor
Resistant
:
B
EGFR inhibitor
Resistant: B - Late Trials
EGFR inhibitor
Resistant
:
B
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
osimertinib
Resistant: C3 – Early Trials
osimertinib
Resistant
:
C3
osimertinib
Resistant: C3 – Early Trials
osimertinib
Resistant
:
C3
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
EGFR mutation + TP53 mutation
Lung Adenocarcinoma
EGFR mutation + TP53 mutation
Lung Adenocarcinoma
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
EGFR mutation + TP53 mutation
Pancreatic Cancer
EGFR mutation + TP53 mutation
Pancreatic Cancer
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
aumolertinib
Sensitive: C3 – Early Trials
aumolertinib
Sensitive
:
C3
aumolertinib
Sensitive: C3 – Early Trials
aumolertinib
Sensitive
:
C3
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR inhibitor + Angiogenesis inhibitor
Sensitive: C3 – Early Trials
EGFR inhibitor + Angiogenesis inhibitor
Sensitive
:
C3
EGFR inhibitor + Angiogenesis inhibitor
Sensitive: C3 – Early Trials
EGFR inhibitor + Angiogenesis inhibitor
Sensitive
:
C3
EGFR mutation + TP53 mutation
Lung Cancer
EGFR mutation + TP53 mutation
Lung Cancer
osimertinib
Resistant: C3 – Early Trials
osimertinib
Resistant
:
C3
osimertinib
Resistant: C3 – Early Trials
osimertinib
Resistant
:
C3
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
EGFR mutation + TP53 mutation
Lung Adenocarcinoma
EGFR mutation + TP53 mutation
Lung Adenocarcinoma
EGFR inhibitor
Resistant: C3 – Early Trials
EGFR inhibitor
Resistant
:
C3
EGFR inhibitor
Resistant: C3 – Early Trials
EGFR inhibitor
Resistant
:
C3
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
EGFR mutation + TP53 mutation
Non Small Cell Lung Cancer
bevacizumab + aumolertinib
Sensitive: C3 – Early Trials
bevacizumab + aumolertinib
Sensitive
:
C3
bevacizumab + aumolertinib
Sensitive: C3 – Early Trials
bevacizumab + aumolertinib
Sensitive
:
C3
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