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    Association details:
    Biomarker:EGFR mutation + TP53 mutation
    Cancer:Lung Adenocarcinoma
    Drug Class:EGFR inhibitor
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: C3 – Early Trials
    Source:
    Cancer Res Treat
    Title:

    Clinical Impact of Genomic and Pathway Alterations in Stage I EGFR-Mutant Lung Adenocarcinoma

    Published date:
    07/24/2023
    Excerpt:
    Out of the initial cohort of 257 patients with completely resected stage I EGFR-mutant lung adenocarcinoma, tumor samples from 105 patients were subjected to analysis using large-panel next-generation sequencing….Additionally, in patients with recurrence treated with EGFR-TKIs, co-occurring TP53 mutations were linked to shorter progression-free survival (p=0.025).
    DOI:
    https://doi.org/10.4143/crt.2023.728