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BIOMARKER:

BRCA2 mutation + HER-2 negative

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Entrez ID:

Related biomarkers:

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BRCA2 mutation (200)

HER-2 mutation (89)

HER-2 exon 20 insertion (27)

HER-2 L755S (26)

BRCA wild-type (19)

HER-2 A775_G776insYVMA (10)

HER-2 S310F (10)

HER-2 V777L (10)

HER-2 L755P (7)

HER-2 S310Y (6)

HER-2 G778_P780dup (5)

HER-2 L768S (4)

HER-2 Y772_A775dup (4)

HER-2 exon 20 mutation (4)

BRCA1 mutation + BRCA2 mutation (4)

HER-2 C634R (3)

HER-2 D769Y (3)

HER-2 I655V (3)

HER-2 K753E (3)

HER-2 L869R (3)

HER-2 V777L + EGFR L858R (3)

HER-2 V842I (3)

BRCA2 A902fs*2 (3)

HER-2 G776insV_C (2)

HER-2 G776insV_G (2)

HER-2 G778_S779insCPG (2)

HER-2 G780_P781dupGSP (2)

HER-2 H878Y (2)

HER-2 L755_T759del (2)

HER-2 L866M (2)

HER-2 T798M (2)

HER-2 T862A + HER-2 L755S (2)

HER-2 V773A (2)

HER-2 V773L (2)

HER-2 V777L + PIK3CA H1047R (2)

HER-2 exon 20 YVMA insertion (2)

HER-2 exon 20G776>VC insertion (2)

BRCA2 mutation + CHEK2 mutation (2)

BRCA2 mutation + TP53 mutation (2)

BRCA2 rearrangement (2)

ALK rearrangement + HER-2 mutation (1)

EGFR L858R + TP53 R273C + HER-2 S442L (1)

EGFR T790M + HER-2 mutation (1)

ERBB3 mutation + HER-2 mutation (1)

HER-2 1899‐1G>A (1)

HER-2 755_759del (1)

HER-2 778insGSP (1)

HER-2 A1170P (1)

HER-2 D769H (1)

HER-2 E395K (1)

HER-2 G309A (1)

HER-2 G660D + HER-2 S310F (1)

HER-2 G766V (1)

HER-2 G776L (1)

HER-2 G776S (1)

HER-2 K676R (1)

HER-2 L726I (1)

HER-2 M774delinsWLV (1)

HER-2 N857S (1)

HER-2 P780-Y781insGSP (1)

HER-2 P780ins (1)

HER-2 Q680R (1)

HER-2 R647K (1)

HER-2 R678Q (1)

HER-2 R784G (1)

HER-2 R896C (1)

HER-2 R896G (1)

HER-2 S335C (1)

HER-2 T798I (1)

HER-2 T862A (1)

HER-2 V658E (1)

HER-2 V659D (1)

HER-2 exon 17 mutation (1)

HER-2 exon 19 mutation (1)

HER-2 exon 20 G776delinsVC (1)

HER-2 exon 23 mutation (1)

HER-2 mutation + CDK6 mutation (1)

HER-2 mutation + HER-2 T798I (1)

HER-2 mutation + TP53 wild-type (1)

HER-2 rearrangement (1)

p95HER2 mutation (1)

APC mutation + BRCA2 mutation (1)

BRCA2 1153insT (1)

BRCA2 5396insC (1)

BRCA2 I2315T (1)

BRCA2 L557* (1)

BRCA2 N255fs + D252fs (1)

BRCA2 Y1655* + TP53 mutation (1)

BRCA2 biallelic inactivation (1)

BRCA2 mutation + ATM mutation (1)

BRCA2 mutation + CDK12 mutation (1)

BRCA2 mutation + SPOP mutation (1)

BRCA2 mutation + TP53 D816Y (1)

CHEK2 mutation + ATM mutation + BRCA2 mutation (1)

EGFR exon 19 deletion + BRCA2 mutation (1)

HER-2 negative + HR positive + PTEN mutation (0)

HER-2 negative + ER positive + ESR1 mutation (0)

HER-2 negative + HR negative + BRCA mutation (0)

HER-2 negative + HR positive + AKT1 mutation (0)

HER-2 negative + HR positive + BRCA mutation (0)

HER-2 negative + HR positive + ESR1 mutation (0)

HER-2 negative + HR positive + ESR1 mutation + PIK3CA mutation (0)

HER-2 negative + HR positive + ESR1 wild-type (0)

HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)

HER-2 negative + HR positive + PIK3CA mutation (0)

BRCA2 E260fs (0)

BRCA2 N255_R259delinsIK (0)

BRCA2 N255fs (0)

BRCA2 N255fs + BRCA2 N255_R259delinsIK + BRCA2 E260fs (0)

BRCA2 mutation (200)

HER-2 mutation (89)

HER-2 exon 20 insertion (27)

HER-2 L755S (26)

BRCA wild-type (19)

HER-2 A775_G776insYVMA (10)

HER-2 S310F (10)

HER-2 V777L (10)

HER-2 L755P (7)

HER-2 S310Y (6)

HER-2 G778_P780dup (5)

HER-2 L768S (4)

HER-2 Y772_A775dup (4)

HER-2 exon 20 mutation (4)

BRCA1 mutation + BRCA2 mutation (4)

HER-2 C634R (3)

HER-2 D769Y (3)

HER-2 I655V (3)

HER-2 K753E (3)

HER-2 L869R (3)

HER-2 V777L + EGFR L858R (3)

HER-2 V842I (3)

BRCA2 A902fs*2 (3)

HER-2 G776insV_C (2)

HER-2 G776insV_G (2)

HER-2 G778_S779insCPG (2)

HER-2 G780_P781dupGSP (2)

HER-2 H878Y (2)

HER-2 L755_T759del (2)

HER-2 L866M (2)

HER-2 T798M (2)

HER-2 T862A + HER-2 L755S (2)

HER-2 V773A (2)

HER-2 V773L (2)

HER-2 V777L + PIK3CA H1047R (2)

HER-2 exon 20 YVMA insertion (2)

HER-2 exon 20G776>VC insertion (2)

BRCA2 mutation + CHEK2 mutation (2)

BRCA2 mutation + TP53 mutation (2)

BRCA2 rearrangement (2)

ALK rearrangement + HER-2 mutation (1)

EGFR L858R + TP53 R273C + HER-2 S442L (1)

EGFR T790M + HER-2 mutation (1)

ERBB3 mutation + HER-2 mutation (1)

HER-2 1899‐1G>A (1)

HER-2 755_759del (1)

HER-2 778insGSP (1)

HER-2 A1170P (1)

HER-2 D769H (1)

HER-2 E395K (1)

HER-2 G309A (1)

HER-2 G660D + HER-2 S310F (1)

HER-2 G766V (1)

HER-2 G776L (1)

HER-2 G776S (1)

HER-2 K676R (1)

HER-2 L726I (1)

HER-2 M774delinsWLV (1)

HER-2 N857S (1)

HER-2 P780-Y781insGSP (1)

HER-2 P780ins (1)

HER-2 Q680R (1)

HER-2 R647K (1)

HER-2 R678Q (1)

HER-2 R784G (1)

HER-2 R896C (1)

HER-2 R896G (1)

HER-2 S335C (1)

HER-2 T798I (1)

HER-2 T862A (1)

HER-2 V658E (1)

HER-2 V659D (1)

HER-2 exon 17 mutation (1)

HER-2 exon 19 mutation (1)

HER-2 exon 20 G776delinsVC (1)

HER-2 exon 23 mutation (1)

HER-2 mutation + CDK6 mutation (1)

HER-2 mutation + HER-2 T798I (1)

HER-2 mutation + TP53 wild-type (1)

HER-2 rearrangement (1)

p95HER2 mutation (1)

APC mutation + BRCA2 mutation (1)

BRCA2 1153insT (1)

BRCA2 5396insC (1)

BRCA2 I2315T (1)

BRCA2 L557* (1)

BRCA2 N255fs + D252fs (1)

BRCA2 Y1655* + TP53 mutation (1)

BRCA2 biallelic inactivation (1)

BRCA2 mutation + ATM mutation (1)

BRCA2 mutation + CDK12 mutation (1)

BRCA2 mutation + SPOP mutation (1)

BRCA2 mutation + TP53 D816Y (1)

CHEK2 mutation + ATM mutation + BRCA2 mutation (1)

EGFR exon 19 deletion + BRCA2 mutation (1)

HER-2 negative + HR positive + PTEN mutation (0)

HER-2 negative + ER positive + ESR1 mutation (0)

HER-2 negative + HR negative + BRCA mutation (0)

HER-2 negative + HR positive + AKT1 mutation (0)

HER-2 negative + HR positive + BRCA mutation (0)

HER-2 negative + HR positive + ESR1 mutation (0)

HER-2 negative + HR positive + ESR1 mutation + PIK3CA mutation (0)

HER-2 negative + HR positive + ESR1 wild-type (0)

HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)

HER-2 negative + HR positive + PIK3CA mutation (0)

BRCA2 E260fs (0)

BRCA2 N255_R259delinsIK (0)

BRCA2 N255fs (0)

BRCA2 N255fs + BRCA2 N255_R259delinsIK + BRCA2 E260fs (0)

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BRCA2 mutation + HER-2 negative	HER2 Negative Breast Cancer	BRCA2 mutation + HER-2 negative	HER2 Negative Breast Cancer	olaparib Sensitive: B - Late Trials olaparib Sensitive : B	olaparib Sensitive: B - Late Trials olaparib Sensitive : B
BRCA2 mutation + HER-2 negative	Breast Cancer	BRCA2 mutation + HER-2 negative	Breast Cancer	niraparib Sensitive: C3 – Early Trials niraparib Sensitive : C3	niraparib Sensitive: C3 – Early Trials niraparib Sensitive : C3