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BIOMARKER:
BRCA wild-type
i
Other names:
BRCA1, BRCC1, PPP1R53, RNF53, Breast cancer 1, early onset, BRCA2, BRCC2, FACD, FAD, FAD1, FANCD, FANCD1, Breast cancer 2, early onset
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Entrez ID:
672
;
675
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
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Associations
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VERI cancer hierarchy
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BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
rucaparib
Sensitive: A2 - Guideline
rucaparib
Sensitive
:
A2
rucaparib
Sensitive: A2 - Guideline
rucaparib
Sensitive
:
A2
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
ABT-888
Sensitive: B - Late Trials
ABT-888
Sensitive
:
B
ABT-888
Sensitive: B - Late Trials
ABT-888
Sensitive
:
B
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
bevacizumab + olaparib + durvalumab
Sensitive: B - Late Trials
bevacizumab + olaparib + durvalumab
Sensitive
:
B
bevacizumab + olaparib + durvalumab
Sensitive: B - Late Trials
bevacizumab + olaparib + durvalumab
Sensitive
:
B
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
AZD1775
Sensitive: C2 – Inclusion Criteria
AZD1775
Sensitive
:
C2
AZD1775
Sensitive: C2 – Inclusion Criteria
AZD1775
Sensitive
:
C2
BRCA wild-type
Triple Negative Breast Cancer
BRCA wild-type
Triple Negative Breast Cancer
olaparib + alpelisib
Sensitive: C3 – Early Trials
olaparib + alpelisib
Sensitive
:
C3
olaparib + alpelisib
Sensitive: C3 – Early Trials
olaparib + alpelisib
Sensitive
:
C3
BRCA wild-type
Breast Cancer
BRCA wild-type
Breast Cancer
talazoparib
Sensitive: C3 – Early Trials
talazoparib
Sensitive
:
C3
talazoparib
Sensitive: C3 – Early Trials
talazoparib
Sensitive
:
C3
BRCA wild-type
Triple Negative Breast Cancer
BRCA wild-type
Triple Negative Breast Cancer
ACR-368
Sensitive: C3 – Early Trials
ACR-368
Sensitive
:
C3
ACR-368
Sensitive: C3 – Early Trials
ACR-368
Sensitive
:
C3
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
pembrolizumab + bevacizumab + olaparib
Sensitive: C3 – Early Trials
pembrolizumab + bevacizumab + olaparib
Sensitive
:
C3
pembrolizumab + bevacizumab + olaparib
Sensitive: C3 – Early Trials
pembrolizumab + bevacizumab + olaparib
Sensitive
:
C3
BRCA wild-type
Triple Negative Breast Cancer
BRCA wild-type
Triple Negative Breast Cancer
talazoparib + ZEN-3694
Sensitive: C3 – Early Trials
talazoparib + ZEN-3694
Sensitive
:
C3
talazoparib + ZEN-3694
Sensitive: C3 – Early Trials
talazoparib + ZEN-3694
Sensitive
:
C3
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
bortezomib
Sensitive: C3 – Early Trials
bortezomib
Sensitive
:
C3
bortezomib
Sensitive: C3 – Early Trials
bortezomib
Sensitive
:
C3
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
carboplatin + paclitaxel
Sensitive: C3 – Early Trials
carboplatin + paclitaxel
Sensitive
:
C3
carboplatin + paclitaxel
Sensitive: C3 – Early Trials
carboplatin + paclitaxel
Sensitive
:
C3
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
bevacizumab + olaparib + atezolizumab
Sensitive: C3 – Early Trials
bevacizumab + olaparib + atezolizumab
Sensitive
:
C3
bevacizumab + olaparib + atezolizumab
Sensitive: C3 – Early Trials
bevacizumab + olaparib + atezolizumab
Sensitive
:
C3
BRCA wild-type
Triple Negative Breast Cancer
BRCA wild-type
Triple Negative Breast Cancer
carboplatin + paclitaxel + cyclophosphamide
Sensitive: C3 – Early Trials
carboplatin + paclitaxel + cyclophosphamide
Sensitive
:
C3
carboplatin + paclitaxel + cyclophosphamide
Sensitive: C3 – Early Trials
carboplatin + paclitaxel + cyclophosphamide
Sensitive
:
C3
BRCA wild-type
HER2 Negative Breast Cancer
BRCA wild-type
HER2 Negative Breast Cancer
DAN-222
Sensitive: C3 – Early Trials
DAN-222
Sensitive
:
C3
DAN-222
Sensitive: C3 – Early Trials
DAN-222
Sensitive
:
C3
BRCA wild-type
HER2 Negative Breast Cancer
BRCA wild-type
HER2 Negative Breast Cancer
niraparib + DAN-222
Sensitive: C3 – Early Trials
niraparib + DAN-222
Sensitive
:
C3
niraparib + DAN-222
Sensitive: C3 – Early Trials
niraparib + DAN-222
Sensitive
:
C3
BRCA wild-type
Triple Negative Breast Cancer
BRCA wild-type
Triple Negative Breast Cancer
MLN4924
Sensitive: D – Preclinical
MLN4924
Sensitive
:
D
MLN4924
Sensitive: D – Preclinical
MLN4924
Sensitive
:
D
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
olaparib + ART12
Sensitive: D – Preclinical
olaparib + ART12
Sensitive
:
D
olaparib + ART12
Sensitive: D – Preclinical
olaparib + ART12
Sensitive
:
D
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
olaparib + cediranib + 3-AP
Sensitive: D – Preclinical
olaparib + cediranib + 3-AP
Sensitive
:
D
olaparib + cediranib + 3-AP
Sensitive: D – Preclinical
olaparib + cediranib + 3-AP
Sensitive
:
D
BRCA wild-type
Triple Negative Breast Cancer
BRCA wild-type
Triple Negative Breast Cancer
olaparib + AZD1775
Sensitive: D – Preclinical
olaparib + AZD1775
Sensitive
:
D
olaparib + AZD1775
Sensitive: D – Preclinical
olaparib + AZD1775
Sensitive
:
D
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