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BIOMARKER:
TP53 Y220C
i
Other names:
TP53, Tumor Protein P53, Cellular Tumor Antigen P53, Phosphoprotein P53, Tumor Protein P53, Antigen NY-CO-13, Transformation-Related Protein 53, Mutant Tumor Protein 53, P53 Tumor Suppressor, Tumor Suppressor P53, Tumor Protein 53, BMFS5, TRP53, BCC7, LFS1
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Entrez ID:
7157
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
TP53 mutation + Chr del(17p) (14)
FGF19 amplification + HRAS Q61R + TP53 672+2T>G (6)
FGF3 amplification + HRAS Q61R + TP53 672+2T>G (6)
FGF4 amplification + HRAS Q61R + TP53 672+2T>G (6)
EML4-ALK variant 3 + TP53 mutation (5)
TP53 mutation + ALK positive (4)
BRCA wild-type + TP53 mutation (3)
TP53 mutation + Chr del(11q) (3)
ALK fusion + TP53 mutation (2)
EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)
EML4-ALK fusion + TP53 mutation (2)
HR positive + TP53 mutation (2)
ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)
ALK negative + TP53 deletion (1)
ALK positive + EML4-ALK fusion + TP53 mutation (1)
CD74-ROS1 fusion + TP53 mutation (1)
CPE-ALK fusion + TP53 wild-type (1)
Chr del(5q) + TP53 expression (1)
Chr t(11;14) + TP53 mutation (1)
EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)
EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)
EGFR exon 19 deletion + TP53 mutation + MET amplification (1)
EGFR exon 20 insertion + TP53 mutation (1)
EGFR expression + TP53 mutation (1)
EGFR mutation + MET amplification + TP53 mutation (1)
EGFR mutation + PD-L1 expression + TP53 mutation (1)
EGFR mutation + TP53 expression (1)
FAT1 mutation + TP53 wild-type (1)
FLT3 wild-type + TP53 mutation (1)
FLT3-ITD mutation + MLL fusion + TP53 mutation (1)
GNA13 deletion + TP53 mutation (1)
HER-2 positive + TP53 mutation (1)
HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)
IDH wild-type + FGFR3 S249C + TP53 V73fs (1)
IDH1 mutation + ATRX deletion + TP53 deletion (1)
KDR amplification + FLT4 amplification + MCL1 amplification + TP53 R213 + TP53 H179Y + ARID1A Q2128 (1)
KIF5B-RET fusion + TP53 H193R + MYC amplification (1)
KRAS G12D + TP53 deletion (1)
KRAS mutation + TP53 mutation + GNA13 deletion (1)
KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)
LDH elevation + TP53 mutation (1)
LRP1B mutation + TP53 wild-type (1)
MDM2 amplification + TP53 wild-type (1)
MDM2 amplification + TP53 wild-type + TWIST1 amplification (1)
MET amplification + TP53 mutation (1)
MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)
MSI-H/dMMR + TP53 mutation (1)
MSLN overexpression + TP53 mutation (1)
PD-L1 overexpression + KRAS G12C + TP53 mutation (1)
PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)
ROS1 fusion + TP53 mutation (1)
ROS1-CD74 fusion + TP53 K139N (1)
SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)
STK11 mutation + KRAS mutation + TP53 deletion (1)
TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)
TMEM87A-RASGRF1 fusion + TP53 R273H (1)
TP53 R280K + BRCA wild-type (1)
TP53 S12F + KRAS G12D + TMB-L (1)
TP53 deletion + RB1 deletion + CTSK expression (1)
TP53 mutation + FANCM mutation + TMB-H (1)
TP53 mutation + FGFR2 fusion (1)
TP53 mutation + LRP1B mutation + TMB-H (1)
TP53 mutation + MET amplification + PD-L1 overexpression (1)
TP53 mutation + PD-L1 expression (1)
TP53 mutation + PD-L1 negative (1)
TP53 mutation + TMB-H + PD-L1 overexpression (1)
TP53 wild-type + ER positive (1)
FGFR2 K660N + TP53 deletion (0)
TP53 mutation + Chr del(17p) (14)
FGF19 amplification + HRAS Q61R + TP53 672+2T>G (6)
FGF3 amplification + HRAS Q61R + TP53 672+2T>G (6)
FGF4 amplification + HRAS Q61R + TP53 672+2T>G (6)
EML4-ALK variant 3 + TP53 mutation (5)
TP53 mutation + ALK positive (4)
BRCA wild-type + TP53 mutation (3)
TP53 mutation + Chr del(11q) (3)
ALK fusion + TP53 mutation (2)
EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)
EML4-ALK fusion + TP53 mutation (2)
HR positive + TP53 mutation (2)
ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)
ALK negative + TP53 deletion (1)
ALK positive + EML4-ALK fusion + TP53 mutation (1)
CD74-ROS1 fusion + TP53 mutation (1)
CPE-ALK fusion + TP53 wild-type (1)
Chr del(5q) + TP53 expression (1)
Chr t(11;14) + TP53 mutation (1)
EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)
EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)
EGFR exon 19 deletion + TP53 mutation + MET amplification (1)
EGFR exon 20 insertion + TP53 mutation (1)
EGFR expression + TP53 mutation (1)
EGFR mutation + MET amplification + TP53 mutation (1)
EGFR mutation + PD-L1 expression + TP53 mutation (1)
EGFR mutation + TP53 expression (1)
FAT1 mutation + TP53 wild-type (1)
FLT3 wild-type + TP53 mutation (1)
FLT3-ITD mutation + MLL fusion + TP53 mutation (1)
GNA13 deletion + TP53 mutation (1)
HER-2 positive + TP53 mutation (1)
HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)
IDH wild-type + FGFR3 S249C + TP53 V73fs (1)
IDH1 mutation + ATRX deletion + TP53 deletion (1)
KDR amplification + FLT4 amplification + MCL1 amplification + TP53 R213 + TP53 H179Y + ARID1A Q2128 (1)
KIF5B-RET fusion + TP53 H193R + MYC amplification (1)
KRAS G12D + TP53 deletion (1)
KRAS mutation + TP53 mutation + GNA13 deletion (1)
KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)
LDH elevation + TP53 mutation (1)
LRP1B mutation + TP53 wild-type (1)
MDM2 amplification + TP53 wild-type (1)
MDM2 amplification + TP53 wild-type + TWIST1 amplification (1)
MET amplification + TP53 mutation (1)
MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)
MSI-H/dMMR + TP53 mutation (1)
MSLN overexpression + TP53 mutation (1)
PD-L1 overexpression + KRAS G12C + TP53 mutation (1)
PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)
ROS1 fusion + TP53 mutation (1)
ROS1-CD74 fusion + TP53 K139N (1)
SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)
STK11 mutation + KRAS mutation + TP53 deletion (1)
TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)
TMEM87A-RASGRF1 fusion + TP53 R273H (1)
TP53 R280K + BRCA wild-type (1)
TP53 S12F + KRAS G12D + TMB-L (1)
TP53 deletion + RB1 deletion + CTSK expression (1)
TP53 mutation + FANCM mutation + TMB-H (1)
TP53 mutation + FGFR2 fusion (1)
TP53 mutation + LRP1B mutation + TMB-H (1)
TP53 mutation + MET amplification + PD-L1 overexpression (1)
TP53 mutation + PD-L1 expression (1)
TP53 mutation + PD-L1 negative (1)
TP53 mutation + TMB-H + PD-L1 overexpression (1)
TP53 wild-type + ER positive (1)
FGFR2 K660N + TP53 deletion (0)
›
Associations
(2)
News
Trials
Search handles
@MPishvaian
@aparna1024
Search handles
@MPishvaian
@aparna1024
Filter by
Latest
over1year
@hopkinskimmel #HopkinsGI 📢Moving on to the Medical Education section of the conference ➡️We are so fortunate that @RonaYaeger from @MSKCancerCenter jumped on a🚆to join us today ➡️She is🗣️targeted therapy for #colorectalcancer 👉BRAF 👉KRASG12C 👉Y220C mut TP53 (@MPishvaian)
over 1 year ago
KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53)
|
KRAS G12C • KRAS G12 • TP53 Y220C
over1year
6th Annual Advances in CRC Oncology: Improving Practice Through New Discoveries Talk by Dr @RonaYaeger #CRCSM #MSKcolorectalCME #colorectalcancer Newer KRAS targeted therapies coming up, TP53 mutations -Y220C targetable, rare mutation in CRC (@manjuggm)
over 1 year ago
KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53)
|
TP53 mutation • TP53 Y220C
almost2years
#Biomarkers‼️biomarkers‼️biomarkers‼️ Hit of dev therapeutics session Not just TP53 Which TP53 mut? Y220C is here to stay! P53 reactivator PC14586 Very rare in CRC-0.6%, similar to NTRK 5 #CRC patients in this trial #CRCTrialsChat (@aparna1024)
almost 2 years ago
Clinical
|
TP53 (Tumor protein P53) • NTRK (Neurotrophic receptor tyrosine kinase)
|
TP53 Y220C
|
rezatapopt (PC14586)
almost2years
$PMVP PC14586 in TP53 Y220C mutant solid tumours: 5/21 PR (3 unconfirmed), some liver enzyme elevation #ASCO22 (@JacobPlieth)
almost 2 years ago
TP53 (Tumor protein P53)
|
TP53 mutation • TP53 Y220C
|
rezatapopt (PC14586)
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