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BIOMARKER:
HER-2 G778_P780dup
i
Other names:
ERBB2, CD340, HER-2, HER2, NEU, NGL, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
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Entrez ID:
2064
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
HER-2 mutation (89)
HER-2 exon 20 insertion (27)
HER-2 L755S (26)
HER-2 A775_G776insYVMA (10)
HER-2 S310F (10)
HER-2 V777L (10)
HER-2 L755P (7)
HER-2 S310Y (6)
HER-2 L768S (4)
HER-2 Y772_A775dup (4)
HER-2 exon 20 mutation (4)
HER-2 C634R (3)
HER-2 D769Y (3)
HER-2 I655V (3)
HER-2 K753E (3)
HER-2 L869R (3)
HER-2 V777L + EGFR L858R (3)
HER-2 V842I (3)
HER-2 G776insV_C (2)
HER-2 G776insV_G (2)
HER-2 G778_S779insCPG (2)
HER-2 G780_P781dupGSP (2)
HER-2 H878Y (2)
HER-2 L755_T759del (2)
HER-2 L866M (2)
HER-2 T798M (2)
HER-2 T862A + HER-2 L755S (2)
HER-2 V773A (2)
HER-2 V773L (2)
HER-2 V777L + PIK3CA H1047R (2)
HER-2 exon 20 YVMA insertion (2)
HER-2 exon 20G776>VC insertion (2)
ALK rearrangement + HER-2 mutation (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR T790M + HER-2 mutation (1)
ERBB3 mutation + HER-2 mutation (1)
HER-2 1899‐1G>A (1)
HER-2 755_759del (1)
HER-2 778insGSP (1)
HER-2 A1170P (1)
HER-2 A775 (1)
HER-2 D769H (1)
HER-2 E395K (1)
HER-2 G309A (1)
HER-2 G660D + HER-2 S310F (1)
HER-2 G766V (1)
HER-2 G776L (1)
HER-2 G776S (1)
HER-2 K676R (1)
HER-2 L726I (1)
HER-2 M774delinsWLV (1)
HER-2 N857S (1)
HER-2 P780-Y781insGSP (1)
HER-2 P780ins (1)
HER-2 Q57R (1)
HER-2 Q680R (1)
HER-2 R647K (1)
HER-2 R678Q (1)
HER-2 R784G (1)
HER-2 R896C (1)
HER-2 R896G (1)
HER-2 S335C (1)
HER-2 T798I (1)
HER-2 T862A (1)
HER-2 V658E (1)
HER-2 V659D (1)
HER-2 YVMA (1)
HER-2 exon 17 mutation (1)
HER-2 exon 19 mutation (1)
HER-2 exon 20 G776delinsVC (1)
HER-2 exon 23 mutation (1)
HER-2 mutation + CDK6 mutation (1)
HER-2 mutation + HER-2 T798I (1)
HER-2 mutation + TP53 wild-type (1)
HER-2 rearrangement (1)
p95HER2 mutation (1)
HER2 L726I (0)
HER-2 mutation (89)
HER-2 exon 20 insertion (27)
HER-2 L755S (26)
HER-2 A775_G776insYVMA (10)
HER-2 S310F (10)
HER-2 V777L (10)
HER-2 L755P (7)
HER-2 S310Y (6)
HER-2 L768S (4)
HER-2 Y772_A775dup (4)
HER-2 exon 20 mutation (4)
HER-2 C634R (3)
HER-2 D769Y (3)
HER-2 I655V (3)
HER-2 K753E (3)
HER-2 L869R (3)
HER-2 V777L + EGFR L858R (3)
HER-2 V842I (3)
HER-2 G776insV_C (2)
HER-2 G776insV_G (2)
HER-2 G778_S779insCPG (2)
HER-2 G780_P781dupGSP (2)
HER-2 H878Y (2)
HER-2 L755_T759del (2)
HER-2 L866M (2)
HER-2 T798M (2)
HER-2 T862A + HER-2 L755S (2)
HER-2 V773A (2)
HER-2 V773L (2)
HER-2 V777L + PIK3CA H1047R (2)
HER-2 exon 20 YVMA insertion (2)
HER-2 exon 20G776>VC insertion (2)
ALK rearrangement + HER-2 mutation (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR T790M + HER-2 mutation (1)
ERBB3 mutation + HER-2 mutation (1)
HER-2 1899‐1G>A (1)
HER-2 755_759del (1)
HER-2 778insGSP (1)
HER-2 A1170P (1)
HER-2 A775 (1)
HER-2 D769H (1)
HER-2 E395K (1)
HER-2 G309A (1)
HER-2 G660D + HER-2 S310F (1)
HER-2 G766V (1)
HER-2 G776L (1)
HER-2 G776S (1)
HER-2 K676R (1)
HER-2 L726I (1)
HER-2 M774delinsWLV (1)
HER-2 N857S (1)
HER-2 P780-Y781insGSP (1)
HER-2 P780ins (1)
HER-2 Q57R (1)
HER-2 Q680R (1)
HER-2 R647K (1)
HER-2 R678Q (1)
HER-2 R784G (1)
HER-2 R896C (1)
HER-2 R896G (1)
HER-2 S335C (1)
HER-2 T798I (1)
HER-2 T862A (1)
HER-2 V658E (1)
HER-2 V659D (1)
HER-2 YVMA (1)
HER-2 exon 17 mutation (1)
HER-2 exon 19 mutation (1)
HER-2 exon 20 G776delinsVC (1)
HER-2 exon 23 mutation (1)
HER-2 mutation + CDK6 mutation (1)
HER-2 mutation + HER-2 T798I (1)
HER-2 mutation + TP53 wild-type (1)
HER-2 rearrangement (1)
p95HER2 mutation (1)
HER2 L726I (0)
›
Associations
(5)
News
Trials
Search handles
@DrJNaidoo
@Latinamd
@LeXiuning
@StephenVLiu
Search handles
@DrJNaidoo
@Latinamd
@LeXiuning
@StephenVLiu
Filter by
Latest
1year
Poziotinib in Treatment-Naïve HER2 Exon 20 lung cancers: ZENITH20-Cohort 4 ORR 39%, DoR 7.6 mon, G778_P780dupGSP ORR 71%. @EGFRResisters @Exon20Group https://t.co/DvfkrlAD23 (@LeXiuning)
1 year ago
EGFR exon 20 • HER2 exon 20
|
HER-2 (Human epidermal growth factor receptor 2)
|
EGFR exon 20 insertion • EGFR exon 20 mutation • HER-2 G778_P780dup • HER-2 exon 23 mutation
|
Pozenveo (poziotinib)
1year
Poziotinib in Treatment-Naïve HER2 Ex 20 Mutations: ZENITH20-4- Ph2 @JTOonline - N=80 - ORR 39%; DCR 73%; mPFS 5.6m - TRAEs: rash 45% stomatitis, diarrhea 15% - ⬆️ORR 71% in G778_P780dupGS ➡️ FDA declined 2nd line approval in 2022 pending more data #lcsm https://t.co/6CuMFdBTPk (@Latinamd)
1 year ago
FDA event
|
HER-2 (Human epidermal growth factor receptor 2)
|
HER-2 mutation • HER-2 G778_P780dup
|
Pozenveo (poziotinib)
1year
ZENITH20 Ph 2 Trial Poziotinib in HER2mt NSCLC @JTOonline: - 80pts - ORR 39%; DCR 73%; mPFS 5.6m - TRAEs: rash, stomatitis, diarrhea - G778_P780dupGSP HER2 mtn had ⬆️ORR 71% Early signal that mtn subtype matters in HER2mt NSCLC w pozi @OncoAlert #LCSM https://t.co/GXaoXlhOsb (@DrJNaidoo)
1 year ago
HER-2 (Human epidermal growth factor receptor 2)
|
HER-2 G778_P780dup
|
Pozenveo (poziotinib)
1year
Phase II study of 1L poziotinib in #HER2 NSCLC @JTOonline. In 80pts (47 at 16mg qd, 33 at 8mg bid), RR 39%, DCR 73%, mDOR 5.7m, mPFS 5.6m. G3+ AEs include rash (45% qd, 39% bid), mucositis (21%, 15%), diarrhea (15%, 21%). RR 71% in G778_P780dupGSP. https://t.co/hM5IF7UwHb (@StephenVLiu)
1 year ago
HER-2 (Human epidermal growth factor receptor 2)
|
HER-2 G778_P780dup
|
Pozenveo (poziotinib)
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