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The therascreen® EGFR RGQ PCR Kit is a real-time PCR test for the qualitative detection of exon 19 deletions and exon 21 (L858R) substitution mutations of the epidermal growth factor receptor (EGFR) gene in DNA derived from formalin-fixed paraffin-embedded (FFPE) nonsmall cell lung cancer (NSCLC) tumor tissue. The test is intended to be used to select patients with NSCLC for whom GILOTRIF™ (afatinib), an EGFR tyrosine kinase inhibitor (TKI), is indicated. Safety and efficacy of GILOTRIF™ (afatinib) have not been established in patients whose tumors have L861Q, G719X, S768I, exon 20 insertions, and T790M mutations, which are also detected by the therascreen® EGFR RGQ PCR Kit.
Cancer:
Breast Cancer, Non Small Cell Lung Cancer
Gene:
EGFR (Epidermal growth factor receptor)
Drug:
Gilotrif (afatinib), Vizimpro (dacomitinib), gefitinib
Method:
PCR
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