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our Premium Content: News alerts, weekly reports and conference plannersTEST:oncoReveal™ Essential LBx
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Company:
Pillar BiosciType:
Laboratory Developed Test
Related tests:
The oncoRevealTM Essential LBx panel is a robust NGS assay that interrogates 197 targets across 34 genes
of interest* from multiple solid tumor cancer types. This is a focused panel that can detect four types of
variants from cell-free DNA (cfDNA) that has been extracted from plasma: single nucleotide variants (SNVs), small insertion/deletion (indel) variants, copy number amplification (CNA), and microsatellite instability (MSI). The panel uses proprietary Stem-Loop Inhibition-Mediated amplification (SLIMamp®) technology, a tiled amplicon-based library prep chemistry for efficient single-tube target enrichment.
Cancer:
Solid Tumor
Gene:
AKT1 (V-akt murine thymoma viral oncogene homolog 1), ALK (Anaplastic lymphoma kinase), AR (Androgen receptor), ATM (ATM serine/threonine kinase), BRAF (B-raf proto-oncogene), CDK4 (Cyclin-dependent kinase 4)
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AKT1 (V-akt murine thymoma viral oncogene homolog 1), ALK (Anaplastic lymphoma kinase), AR (Androgen receptor), ATM (ATM serine/threonine kinase), BRAF (B-raf proto-oncogene), CDK4 (Cyclin-dependent kinase 4), CTNNB1 (Catenin (cadherin-associated protein), beta 1), EGFR (Epidermal growth factor receptor), ER (Estrogen receptor), ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3), FGFR1 (Fibroblast growth factor receptor 1), FGFR2 (Fibroblast growth factor receptor 2), FGFR3 (Fibroblast growth factor receptor 3), GNA11 (G Protein Subunit Alpha 11), GNAQ (G Protein Subunit Alpha Q), GNAS (GNAS Complex Locus), HER-2 (Human epidermal growth factor receptor 2), HRAS (Harvey rat sarcoma viral oncogene homolog), KIT (KIT proto-oncogene, receptor tyrosine kinase), KRAS (KRAS proto-oncogene GTPase), MET (MET proto-oncogene, receptor tyrosine kinase), NRAS (Neuroblastoma RAS viral oncogene homolog), PDGFRA (Platelet Derived Growth Factor Receptor Alpha), PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), PPP2R1A (Protein Phosphatase 2 Scaffold Subunit Aalpha), PTCH1 (Patched 1), PTEN (Phosphatase and tensin homolog), RAC1 (Rac Family Small GTPase 1), RET (Ret Proto-Oncogene), RNF43 (Ring Finger Protein 43), SF3B1 (Splicing Factor 3b Subunit 1), SMAD4 (SMAD family member 4), TERT (Telomerase Reverse Transcriptase), TP53 (Tumor protein P53)
Method:
Next-Generation Sequencing (NGS)
