Idylla™ GeneFusion Panel detects ALK, ROS1, RET, NTRK1/2/3 rearrangements & MET Exon 14 skipping in a single cartridge. It is a unique combination of 2 detection technologies: 1) Direct Detection: Highly sensitive detection of known fusion isoforms by RT-qPCR of sample RNA. 2) Expression Imbalance Analysis: Detection of fusion events without knowledge of the fusion partners by analyzing expression ratios between the 5’ and 3’ ends of the gene.
Melanoma, Non Small Cell Lung Cancer, Renal Cell Carcinoma, Salivary Gland Cancer, Sarcoma
ALK (Anaplastic lymphoma kinase), MET (MET proto-oncogene, receptor tyrosine kinase), NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1), NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2), NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3), RET (Ret Proto-Oncogene)
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