HepatoPredict is an in vitro diagnostic test that supports the clinical decision of liver transplantation in hepatocellular carcinoma (HCC). A molecular signature is integrated with clinical parameters into a predictive algorithm that estimates the risk of HCC recurrence after a liver transplant. It is based on a gene expression signature, measured by a real-time PCR assay, of 4 target genes and 3 housekeeping genes, and clinical parameters combined into a computational algorithm, that can predict the good outcome of the intervention with a successful-curative rate of 92.