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TEST:
Elecsys Anti-p53 Immunoassay

Company:
Roche
Type:
CE Marked
Related tests:
Evidence

News

8ms
Relationship between tumor TP53 gene mutation, circulating anti-p53 antibodies and response to first-line osimertinib in EGFR-mutated NSCLC patients (ESMO 2023)
Conclusions The existence of a TP53 gene mutation in patients' tumor significantly impacted their PFS, suggesting that future clinical trials should include TP53 genotyping at randomization. Baseline quantification of anti-p53 antibodies could also be used to early identify a fraction of patients presenting a TP53 alteration, and identify patients who may benefit less from osimertinib treatment.
Clinical
|
EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53)
|
TP53 mutation • EGFR mutation • EGFR L858R • EGFR exon 19 deletion
|
Elecsys Anti-p53 Immunoassay
|
Tagrisso (osimertinib)
over1year
Comparison between a new assay system, Elecsys Anti-p53, and conventional MESACUP™ for the detection of serum anti-p53 antibodies: A multi-institutional study. (PubMed, Mol Clin Oncol)
When the specificities of the two assays were aligned for all samples, Elecsys demonstrated higher sensitivities for all types of analyzed cancer together, as well as for esophageal, colorectal and breast cancer, respectively. Although positive concordance between the two assay systems was low in terms of specificity, Elecsys had a higher sensitivity than the MESACUP.
Journal • Clinical
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Elecsys Anti-p53 Immunoassay
over3years
New Assay System Elecsys Anti-p53 to Detect Serum Anti-p53 Antibodies in Esophageal Cancer Patients and Colorectal Cancer Patients: Multi-institutional Study. (PubMed, Ann Surg Oncol)
"The new s-p53-Abs assay Elecsys anti-p53 was useful in detecting esophageal and colorectal cancers with high specificity. Adding s-p53-Abs to conventional markers significantly improved the overall detection rates."
Journal • Clinical
|
CEACAM5 (CEA Cell Adhesion Molecule 5) • KRT19 (Keratin 19)
|
Elecsys Anti-p53 Immunoassay