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BIOMARKER:

PTPN11 mutation + NPM1 mutation

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Entrez ID:

Related biomarkers:

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NPM1 mutation (42)

PTPN11 mutation (11)

FLT3 mutation + NPM1 mutation (4)

FLT3-ITD mutation + NPM1 mutation (3)

FLT3‐ITD + NPM1 mutation (3)

FLT3‐ITD mutation + DNMT3A mutation + NPM1 mutation (3)

DNMT3A mutation + NPM1 mutation (2)

NPM1 mutation + DNMT3A mutation (2)

FLT3-ITD F692L + NPM1 mutation (1)

IDH2 R140Q + NPM1 mutation (1)

IDH2 mutation + NPM1 mutation (1)

NPM1 exon 11 mutation (1)

NPM1 mutation + DNMT3A mutation + KMT2D mutation (1)

NPM1 mutation + FLT3-ITD mutation + TET2 mutation + CUX1 mutation (1)

NPM1 mutation + FLT3-TKD mutation (1)

NPM1 mutation + NRAS mutation (1)

NPM1 mutation + SRSF2 mutation (1)

NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

FLT3 mutation + NRAS mutation + PTPN11 mutation (1)

FLT3 mutation + PTPN11 mutation (1)

PTPN11 mutation + KRAS wild-type (1)

NPM1 mutation (42)

PTPN11 mutation (11)

FLT3 mutation + NPM1 mutation (4)

FLT3-ITD mutation + NPM1 mutation (3)

FLT3‐ITD + NPM1 mutation (3)

FLT3‐ITD mutation + DNMT3A mutation + NPM1 mutation (3)

DNMT3A mutation + NPM1 mutation (2)

NPM1 mutation + DNMT3A mutation (2)

FLT3-ITD F692L + NPM1 mutation (1)

IDH2 R140Q + NPM1 mutation (1)

IDH2 mutation + NPM1 mutation (1)

NPM1 exon 11 mutation (1)

NPM1 mutation + DNMT3A mutation + KMT2D mutation (1)

NPM1 mutation + FLT3-ITD mutation + TET2 mutation + CUX1 mutation (1)

NPM1 mutation + FLT3-TKD mutation (1)

NPM1 mutation + NRAS mutation (1)

NPM1 mutation + SRSF2 mutation (1)

NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

FLT3 mutation + NRAS mutation + PTPN11 mutation (1)

FLT3 mutation + PTPN11 mutation (1)

PTPN11 mutation + KRAS wild-type (1)

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3ms

PTPN11 Mutation Clonal Hierarchy in Acute Myeloid Leukemia. (PubMed, bioRxiv)

This immune diversity was reconstituted from early precursor cells when engrafted into immunodeficient mice. Moreover, immune diversity was also observed in the blast component of patient samples with NPM1 and PTPN11 mutations, providing novel antigen targets for immune based approaches in this subset of AML that is resistant to multiple targeted therapies.

3 months ago

Journal

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NPM1 (Nucleophosmin 1) • PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11)

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NPM1 mutation • PTPN11 mutation • PTPN11 mutation + NPM1 mutation

almost4years

[VIRTUAL] The Clinicopathological Features of DNMT3A R882 Mutant Myeloid Neoplasms (USCAP 2021)

DNMT3A R882 mutant MNs show unique clinicopathological characteristics. They are more associated with AML and high-grade MDS at presentation in comparison to DNMT3A non-R882 mutant MNs. A clinical study with a larger cohort is needed to further address the diagnostic and prognostic utilities of DNMT3A R882 mutations.

almost 4 years ago

Clinical

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TP53 (Tumor protein P53) • NPM1 (Nucleophosmin 1) • DNMT3A (DNA methyltransferase 1) • PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11) • U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1)

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TP53 mutation • NPM1 mutation • DNMT3A mutation • PTPN11 mutation • U2AF1 mutation • DNMT3A R882 • PTPN11 mutation + NPM1 mutation