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    BIOMARKER:

    PTPN11 mutation + NPM1 mutation

    i
    Other names: PTPN11, Protein Tyrosine Phosphatase Non-Receptor Type 11, Tyrosine-Protein Phosphatase Non-Receptor Type 11, Protein-Tyrosine Phosphatase 1D, Protein-Tyrosine Phosphatase 2C, SH-PTP2, SH-PTP3, PTP-1D, PTP2C, Protein Tyrosine Phosphatase Non-Receptor Type 11, Noonan Syndrome 1, METCDS, PTP-2C, SHPTP2, BPTP3, SHP-2, JMML, SHP2, Shp2, CFC, NS1, Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin), Testicular Tissue Protein Li 128, Nucleolar Protein NO38, Numatrin, NPM1, Nucleophosmin 1, Nucleoph
    Entrez ID:
    4869; 5781
    Related biomarkers:
    Expression
    Mutation
    Fusion
    Others
    Associations

    News

    Trials
    2ms
    PTPN11 Mutation Clonal Hierarchy in Acute Myeloid Leukemia. (PubMed, bioRxiv)
    This immune diversity was reconstituted from early precursor cells when engrafted into immunodeficient mice. Moreover, immune diversity was also observed in the blast component of patient samples with NPM1 and PTPN11 mutations, providing novel antigen targets for immune based approaches in this subset of AML that is resistant to multiple targeted therapies.
    Journal
    |
    NPM1 (Nucleophosmin 1) • PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11)
    |
    NPM1 mutation • PTPN11 mutation • PTPN11 mutation + NPM1 mutation
    over3years
    [VIRTUAL] The Clinicopathological Features of DNMT3A R882 Mutant Myeloid Neoplasms (USCAP 2021)
    DNMT3A R882 mutant MNs show unique clinicopathological characteristics. They are more associated with AML and high-grade MDS at presentation in comparison to DNMT3A non-R882 mutant MNs. A clinical study with a larger cohort is needed to further address the diagnostic and prognostic utilities of DNMT3A R882 mutations.
    Clinical
    |
    TP53 (Tumor protein P53) • NPM1 (Nucleophosmin 1) • DNMT3A (DNA methyltransferase 1) • PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11) • U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1)
    |
    TP53 mutation • NPM1 mutation • DNMT3A mutation • PTPN11 mutation • U2AF1 mutation • DNMT3A R882 • PTPN11 mutation + NPM1 mutation