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    DRUG:

    NBE-002

    i
    Other names: NBE-002, PNU-159682-anti-ROR1 antibody drug conjugate, huXBR1-402-G5-PNU, BI 3702025
    Company:
    Boehringer Ingelheim, Sotio
    Drug class:
    DNA replication inhibitor, ROR1-targeted antibody-drug conjugate
    Related drugs:
    over3years
    [VIRTUAL] NBE-002: A novel anthracycline-based antibody-drug conjugate (ADC) targeting ROR1 for the treatment of advanced solid tumors—A phase 1/2 clinical trial. (ASCO 2021)
    Ph 1 dose escalation was initiated on 17 JULY 2020 and is still recruiting in the US . Ph 2 is planned to be initiated in 2022.
    Clinical • P1/2 data
    |
    CD8 (cluster of differentiation 8) • ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1)
    |
    ROR1 expression
    |
    NBE-002