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BIOMARKER:

EGFR V774_C775insHV

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Entrez ID:

Related biomarkers:

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EGFR exon 19 deletion + EGFR T790M (10)

EGFR mutation + PD-L1 overexpression (8)

MET amplification + EGFR mutation (8)

EGFR exon 19 deletion + PD-L1 overexpression (5)

EGFR mutation + MET amplification (5)

EGFR mutation + PD-L1 expression (5)

EGFR exon 19 deletion + EGFR L643V (4)

EGFR exon 19 deletion + EGFR T790M + EGFR C797S + CTNNB1 exon 3 mutation (4)

PD-L1 expression + EGFR mutation (4)

TA-MUC1 elevation + EGFR expression (4)

TNFRSF10A overexpression + EGFR mutation (4)

EGFR exon 19 deletion + EGFR G724S (3)

EGFR exon 19 deletion + NRAS Q61K (3)

EGFR exon 19 deletion + PTEN K237Cfs*17 (3)

EGFR mutation + ANKRD1 overexpression (3)

EGFR mutation + EGFR amplification (3)

EGFR mutation + MET overexpression (3)

EGFR wild-type + ALK wild-type + PD-L1 expression (3)

MET overexpression + EGFR mutation (3)

AXL expression + EGFR mutation (2)

EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)

EGFR L858R + EGFR exon 19 deletion (2)

EGFR L858R + PD-L1 overexpression (2)

EGFR L858R + VOPP1-EGFR fusion + EGFR T790M (2)

EGFR exon 19 deletion + MET amplification (2)

EGFR exon 19 deletion + EGFR K754E (2)

EGFR exon 19 deletion + EGFR L861Q + EGFR G873E (2)

EGFR exon 19 deletion + KRAS mutation (2)

EGFR exon 19 deletion + PD-L1 expression (2)

EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)

EGFR exon 20 insertion + EGFR amplification (2)

EGFR mutation + BCL2L11 deletion (2)

EGFR mutation + CDCA3 underexpression (2)

EGFR mutation + PTEN deletion (2)

EGFR mutation + RET fusion (2)

EGFR mutation + YAP1 overexpression (2)

EGFR mutation + YES1 overexpression (2)

EGFR-SEPTIN14 fusion + EGFR amplification (2)

EGFR exon 19 deletion + MET Amplification + MET D1228V (2)

EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)

ERBB3 mutation + TMB-H (2)

HER-2 amplification + EGFR-ZNF880 fusion + EGFR E114K (2)

PD-L1 overexpression + EGFR mutation (2)

TMB-H + EGFR exon 19 deletion (2)

TMB-H + EGFR mutation (2)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

APC V2194fs + EGFR amplification + EGFR-SEPTIN14 fusion (1)

APOA1 elevation + EGFR T790M (1)

ARID1A underexpression + EGFR mutation (1)

ATM expression + ATM T2333fs* + EGFR negative (1)

AXL overexpression + EGFR mutation (1)

AXL underexpression + EGFR mutation (1)

BCL2L11 deletion + EGFR T790M (1)

BRAF V600E + EGFR expression (1)

CCDC6-RET fusion + EGFR mutation (1)

CD276 underexpression + EGFR mutation (1)

CD74-NRG1 fusion + EGFR mutation + HER-2 mutation (1)

CRKL overexpression + EGFR mutation (1)

EGFR C797S + KRAS amplification + RB1 deletion (1)

EGFR C797S + MET amplification (1)

EGFR E746_A750del + KRAS amplification (1)

EGFR G719A + EGFR S768I + PD-L1 overexpression (1)

EGFR G719A + PD-L1 overexpression (1)

EGFR G719D + EGFR L861Q + CUX1-MET fusion (1)

EGFR L747P + PD-L1 overexpression (1)

EGFR L747_A750delinsP + MET D1228H + MET D1228N + MET D1228Y + MET Y1230H + MET amplification (1)

EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)

EGFR L858R + KDR overexpression + VEGFC overexpression (1)

EGFR L858R + KRAS amplification + RB1 deletion (1)

EGFR L858R + MET amplification (1)

EGFR L858R + MET overexpression (1)

EGFR L858R + MET positive (1)

EGFR L858R + PD-L1 expression (1)

EGFR L858R + PD-L1 underexpression (1)

EGFR L858R + ROS1 fusion (1)

EGFR L858R + ROS1-ADGRG6 fusion (1)

EGFR L858R + TMB-H (1)

EGFR L858R + VEGFA-L (1)

EGFR P719A + PD-L1 overexpression (1)

EGFR T263P + EGFR L858R + MET amplification (1)

EGFR T790M + HER-2 amplification (1)

EGFR T790M + KRAS amplification + RB1 deletion (1)

EGFR T790M + MET amplification (1)

EGFR T790M + MET positive (1)

EGFR T790M + MYC amplification (1)

EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)

EGFR T790M + TMB-H (1)

EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)

EGFR exon 19 deletion + ALK amplification (1)

EGFR exon 19 deletion + BRAF G464A (1)

EGFR exon 19 deletion + CCND1 overexpression (1)

EGFR exon 19 deletion + EGFR L747S (1)

EGFR exon 19 deletion + EGFR S768I (1)

EGFR exon 19 deletion + EGFR T790M + EGFR C797S + HER-2 amplification (1)

EGFR exon 19 deletion + EGFR T790M + PD-L1 expression (1)

EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)

EGFR exon 19 deletion + LMNA-NTRK1 fusion + EGFR T790M (1)

EGFR exon 19 deletion + MET positive (1)

EGFR exon 19 deletion + MET amplification (1)

EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y (1)

EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y + MET Y1230C (1)

EGFR exon 19 deletion + PD-L1 underexpression (1)

EGFR exon 19 deletion + PTEN deletion + PIK3CA overexpression (1)

EGFR exon 19 deletion + RBM10 S167* (1)

EGFR exon 19 deletion + STRN-ALK fusion (1)

EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)

EGFR exon 19 deletion + TP53 mutation + MET amplification (1)

EGFR exon 19 deletion + VEGFA-L (1)

EGFR exon 20 insertion + PD-L1 overexpression (1)

EGFR exon 20 insertion + TP53 mutation (1)

EGFR expression + KRAS G12C (1)

EGFR expression + TP53 mutation (1)

EGFR fusion + PD-L1 overexpression (1)

EGFR mutation + ALK negative + TMB-H (1)

EGFR mutation + BCL2L11 overexpression (1)

EGFR mutation + BRCA1 overexpression (1)

EGFR mutation + BRCA1 underexpression (1)

EGFR mutation + CCND1 expression + CDKN2A deletion (1)

EGFR mutation + CD73 overexpression (1)

EGFR mutation + Chr 14q31.1-q31.3 (1)

EGFR mutation + Chr 1p13.3-p13.1 (1)

EGFR mutation + EGFR amplification + MET amplification + MTAP deletion (1)

EGFR mutation + ER positive (1)

EGFR mutation + LANCL2 overexpression (1)

EGFR mutation + LINC00460 overexpression (1)

EGFR mutation + MET amplification + EGFR amplification (1)

EGFR mutation + MET amplification + TP53 mutation (1)

EGFR mutation + MET overexpression + MET amplification (1)

EGFR mutation + MET-CEP7 fusion (1)

EGFR mutation + PD-L1 elevation (1)

EGFR mutation + PD-L1 expression + TP53 mutation (1)

EGFR mutation + PD-L1 negative (1)

EGFR mutation + RBBP8 underexpression (1)

EGFR mutation + ROMO1 overexpression (1)

EGFR mutation + RPS6KB1 amplification (1)

EGFR mutation + S100A9 overexpression (1)

EGFR mutation + SYK overexpression (1)

EGFR mutation + TP53 expression (1)

EGFR mutation + TSLP underexpression (1)

EGFR mutation + TTF1 negative (1)

EGFR mutation + WNT5A expression (1)

EGFR negative + ALK negative + PD-L1 expression (1)

EGFR negative + S100A8 elevation (1)

EGFR negative + S100A9 elevation (1)

EGFR negative + SAA1 elevation (1)

EGFR negative + SAA2 elevation (1)

EGFR overexpression + BRAF V600E (1)

EGFR overexpression + BRAF mutation (1)

EGFR overexpression + KRAS 13D (1)

EGFR overexpression + KRAS mutation (1)

EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)

EGFR wild-type + Chr 11p11.11-q12.1 (1)

EGFR wild-type + Chr 7q31.1-q31.31 (1)

EGFR wild-type + Chr 9q21.31-q22.2 (1)

EGFR wild-type + MET amplification (1)

EGFR wild-type + MET overexpression (1)

EGFR-SEC61G fusion + EGFR amplification (1)

EGFRvIII mutation + EGFR-SEPTIN14 fusion + EGFR amplification (1)

EPHA2 expression + EGFR mutation (1)

ERCC2 positive + SYP negative + EGFR exon 21 mutation (1)

GPRC6A-RET fusion + EGFR mutation (1)

HER-2 amplification + EGFR mutation (1)

HR negative + EGFR amplification (1)

KIF5B-RET fusion + EGFR exon 19 deletion (1)

KRAS mutation + EGFR amplification (1)

MET exon 14 mutation + EGFR wild-type (1)

MET negative + EGFR mutation (1)

MET overexpression + EGFR wild-type (1)

MET positive + EGFR mutation (1)

NOTCH2-NTRK1 fusion + EGFR L858R (1)

PD-L1 underexpression + EGFR mutation (1)

PTGS2 positive + MET positive + PBK positive + EGFR mutation (1)

RBM10 deletion + EGFR mutation (1)

RBM10 underexpression + EGFR mutation (1)

ROS1 translocation + EGFR wild-type (1)

SHTN1-RET fusion + EGFR mutation (1)

SPECC1-RET fusion + EGFR mutation (1)

STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)

TERT mutation + EGFR T790M + EGFR exon 20 insertion (1)

TLN1-RET fusion + EGFR mutation (1)

TRIM24-RET fusion + EGFR mutation (1)

TRIM33-RET fusion + EGFR mutation (1)

CALR elevation + EGFR mutation (0)

HER-2 positive + FGFR1 amplification (0)

PD-L1 underexpression + EGFR wild-type (0)

EGFR exon 19 deletion + EGFR T790M (10)

EGFR mutation + PD-L1 overexpression (8)

MET amplification + EGFR mutation (8)

EGFR exon 19 deletion + PD-L1 overexpression (5)

EGFR mutation + MET amplification (5)

EGFR mutation + PD-L1 expression (5)

EGFR exon 19 deletion + EGFR L643V (4)

EGFR exon 19 deletion + EGFR T790M + EGFR C797S + CTNNB1 exon 3 mutation (4)

PD-L1 expression + EGFR mutation (4)

TA-MUC1 elevation + EGFR expression (4)

TNFRSF10A overexpression + EGFR mutation (4)

EGFR exon 19 deletion + EGFR G724S (3)

EGFR exon 19 deletion + NRAS Q61K (3)

EGFR exon 19 deletion + PTEN K237Cfs*17 (3)

EGFR mutation + ANKRD1 overexpression (3)

EGFR mutation + EGFR amplification (3)

EGFR mutation + MET overexpression (3)

EGFR wild-type + ALK wild-type + PD-L1 expression (3)

MET overexpression + EGFR mutation (3)

AXL expression + EGFR mutation (2)

EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)

EGFR L858R + EGFR exon 19 deletion (2)

EGFR L858R + PD-L1 overexpression (2)

EGFR L858R + VOPP1-EGFR fusion + EGFR T790M (2)

EGFR exon 19 deletion + MET amplification (2)

EGFR exon 19 deletion + EGFR K754E (2)

EGFR exon 19 deletion + EGFR L861Q + EGFR G873E (2)

EGFR exon 19 deletion + KRAS mutation (2)

EGFR exon 19 deletion + PD-L1 expression (2)

EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)

EGFR exon 20 insertion + EGFR amplification (2)

EGFR mutation + BCL2L11 deletion (2)

EGFR mutation + CDCA3 underexpression (2)

EGFR mutation + PTEN deletion (2)

EGFR mutation + RET fusion (2)

EGFR mutation + YAP1 overexpression (2)

EGFR mutation + YES1 overexpression (2)

EGFR-SEPTIN14 fusion + EGFR amplification (2)

EGFR exon 19 deletion + MET Amplification + MET D1228V (2)

EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)

ERBB3 mutation + TMB-H (2)

HER-2 amplification + EGFR-ZNF880 fusion + EGFR E114K (2)

PD-L1 overexpression + EGFR mutation (2)

TMB-H + EGFR exon 19 deletion (2)

TMB-H + EGFR mutation (2)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

APC V2194fs + EGFR amplification + EGFR-SEPTIN14 fusion (1)

APOA1 elevation + EGFR T790M (1)

ARID1A underexpression + EGFR mutation (1)

ATM expression + ATM T2333fs* + EGFR negative (1)

AXL overexpression + EGFR mutation (1)

AXL underexpression + EGFR mutation (1)

BCL2L11 deletion + EGFR T790M (1)

BRAF V600E + EGFR expression (1)

CCDC6-RET fusion + EGFR mutation (1)

CD276 underexpression + EGFR mutation (1)

CD74-NRG1 fusion + EGFR mutation + HER-2 mutation (1)

CRKL overexpression + EGFR mutation (1)

EGFR C797S + KRAS amplification + RB1 deletion (1)

EGFR C797S + MET amplification (1)

EGFR E746_A750del + KRAS amplification (1)

EGFR G719A + EGFR S768I + PD-L1 overexpression (1)

EGFR G719A + PD-L1 overexpression (1)

EGFR G719D + EGFR L861Q + CUX1-MET fusion (1)

EGFR L747P + PD-L1 overexpression (1)

EGFR L747_A750delinsP + MET D1228H + MET D1228N + MET D1228Y + MET Y1230H + MET amplification (1)

EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)

EGFR L858R + KDR overexpression + VEGFC overexpression (1)

EGFR L858R + KRAS amplification + RB1 deletion (1)

EGFR L858R + MET amplification (1)

EGFR L858R + MET overexpression (1)

EGFR L858R + MET positive (1)

EGFR L858R + PD-L1 expression (1)

EGFR L858R + PD-L1 underexpression (1)

EGFR L858R + ROS1 fusion (1)

EGFR L858R + ROS1-ADGRG6 fusion (1)

EGFR L858R + TMB-H (1)

EGFR L858R + VEGFA-L (1)

EGFR P719A + PD-L1 overexpression (1)

EGFR T263P + EGFR L858R + MET amplification (1)

EGFR T790M + HER-2 amplification (1)

EGFR T790M + KRAS amplification + RB1 deletion (1)

EGFR T790M + MET amplification (1)

EGFR T790M + MET positive (1)

EGFR T790M + MYC amplification (1)

EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)

EGFR T790M + TMB-H (1)

EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)

EGFR exon 19 deletion + ALK amplification (1)

EGFR exon 19 deletion + BRAF G464A (1)

EGFR exon 19 deletion + CCND1 overexpression (1)

EGFR exon 19 deletion + EGFR L747S (1)

EGFR exon 19 deletion + EGFR S768I (1)

EGFR exon 19 deletion + EGFR T790M + EGFR C797S + HER-2 amplification (1)

EGFR exon 19 deletion + EGFR T790M + PD-L1 expression (1)

EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)

EGFR exon 19 deletion + LMNA-NTRK1 fusion + EGFR T790M (1)

EGFR exon 19 deletion + MET positive (1)

EGFR exon 19 deletion + MET amplification (1)

EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y (1)

EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y + MET Y1230C (1)

EGFR exon 19 deletion + PD-L1 underexpression (1)

EGFR exon 19 deletion + PTEN deletion + PIK3CA overexpression (1)

EGFR exon 19 deletion + RBM10 S167* (1)

EGFR exon 19 deletion + STRN-ALK fusion (1)

EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)

EGFR exon 19 deletion + TP53 mutation + MET amplification (1)

EGFR exon 19 deletion + VEGFA-L (1)

EGFR exon 20 insertion + PD-L1 overexpression (1)

EGFR exon 20 insertion + TP53 mutation (1)

EGFR expression + KRAS G12C (1)

EGFR expression + TP53 mutation (1)

EGFR fusion + PD-L1 overexpression (1)

EGFR mutation + ALK negative + TMB-H (1)

EGFR mutation + BCL2L11 overexpression (1)

EGFR mutation + BRCA1 overexpression (1)

EGFR mutation + BRCA1 underexpression (1)

EGFR mutation + CCND1 expression + CDKN2A deletion (1)

EGFR mutation + CD73 overexpression (1)

EGFR mutation + Chr 14q31.1-q31.3 (1)

EGFR mutation + Chr 1p13.3-p13.1 (1)

EGFR mutation + EGFR amplification + MET amplification + MTAP deletion (1)

EGFR mutation + ER positive (1)

EGFR mutation + LANCL2 overexpression (1)

EGFR mutation + LINC00460 overexpression (1)

EGFR mutation + MET amplification + EGFR amplification (1)

EGFR mutation + MET amplification + TP53 mutation (1)

EGFR mutation + MET overexpression + MET amplification (1)

EGFR mutation + MET-CEP7 fusion (1)

EGFR mutation + PD-L1 elevation (1)

EGFR mutation + PD-L1 expression + TP53 mutation (1)

EGFR mutation + PD-L1 negative (1)

EGFR mutation + RBBP8 underexpression (1)

EGFR mutation + ROMO1 overexpression (1)

EGFR mutation + RPS6KB1 amplification (1)

EGFR mutation + S100A9 overexpression (1)

EGFR mutation + SYK overexpression (1)

EGFR mutation + TP53 expression (1)

EGFR mutation + TSLP underexpression (1)

EGFR mutation + TTF1 negative (1)

EGFR mutation + WNT5A expression (1)

EGFR negative + ALK negative + PD-L1 expression (1)

EGFR negative + S100A8 elevation (1)

EGFR negative + S100A9 elevation (1)

EGFR negative + SAA1 elevation (1)

EGFR negative + SAA2 elevation (1)

EGFR overexpression + BRAF V600E (1)

EGFR overexpression + BRAF mutation (1)

EGFR overexpression + KRAS 13D (1)

EGFR overexpression + KRAS mutation (1)

EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)

EGFR wild-type + Chr 11p11.11-q12.1 (1)

EGFR wild-type + Chr 7q31.1-q31.31 (1)

EGFR wild-type + Chr 9q21.31-q22.2 (1)

EGFR wild-type + MET amplification (1)

EGFR wild-type + MET overexpression (1)

EGFR-SEC61G fusion + EGFR amplification (1)

EGFRvIII mutation + EGFR-SEPTIN14 fusion + EGFR amplification (1)

EPHA2 expression + EGFR mutation (1)

ERCC2 positive + SYP negative + EGFR exon 21 mutation (1)

GPRC6A-RET fusion + EGFR mutation (1)

HER-2 amplification + EGFR mutation (1)

HR negative + EGFR amplification (1)

KIF5B-RET fusion + EGFR exon 19 deletion (1)

KRAS mutation + EGFR amplification (1)

MET exon 14 mutation + EGFR wild-type (1)

MET negative + EGFR mutation (1)

MET overexpression + EGFR wild-type (1)

MET positive + EGFR mutation (1)

NOTCH2-NTRK1 fusion + EGFR L858R (1)

PD-L1 underexpression + EGFR mutation (1)

PTGS2 positive + MET positive + PBK positive + EGFR mutation (1)

RBM10 deletion + EGFR mutation (1)

RBM10 underexpression + EGFR mutation (1)

ROS1 translocation + EGFR wild-type (1)

SHTN1-RET fusion + EGFR mutation (1)

SPECC1-RET fusion + EGFR mutation (1)

STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)

TERT mutation + EGFR T790M + EGFR exon 20 insertion (1)

TLN1-RET fusion + EGFR mutation (1)

TRIM24-RET fusion + EGFR mutation (1)

TRIM33-RET fusion + EGFR mutation (1)

CALR elevation + EGFR mutation (0)

HER-2 positive + FGFR1 amplification (0)

PD-L1 underexpression + EGFR wild-type (0)

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4years

[VIRTUAL] Brief Report: Immunochemotherapy in Five Patients with EGFR Exon 20 Insertion Advanced Lung Adenocarcinoma (IASLC-WCLC 2020)

Targeted therapy was followed, including afatinib and osimertinib...The first-line treatment was pemetrexed, nedaplatin plus bevacizumab and the second-line treatment was docetaxel plus carboplatin...Patient 4, a 57-year-old female, stage IVB with EGFR 20 ins (D770del) , she received first-line pemetrexed and carboplatin plus pembrolizumab...After the progression of first-line treatment of osimertinib, he received nab-paclitaxel, carboplatin, bevacizumab and durvalumab...It is not clear whether this regimen is appropriate for each of the 20 insertion sites. The therapeutic combination will need more real-world evidences.

4 years ago

Clinical • PD(L)-1 Biomarker • IO biomarker

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EGFR (Epidermal growth factor receptor)

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EGFR mutation • EGFR exon 20 insertion • EGFR exon 20 mutation • EGFR V774_C775insHV

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Keytruda (pembrolizumab) • Avastin (bevacizumab) • Tagrisso (osimertinib) • Gilotrif (afatinib) • carboplatin • Imfinzi (durvalumab) • docetaxel • albumin-bound paclitaxel • pemetrexed • Aqupla (nedaplatin)