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BIOMARKER:

EGFR mutation + PD-L1 overexpression

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Other names: PD-L1, CD274, HPD-L1, PD-L1, B7H1, PDL1, Programmed death ligand 1, B7-H1, B7-H, PDCD1L1, PDCD1LG1, PDCD1 Ligand 1, B7 homolog 1, CD274 Antigen, Programmed cell death 1 ligand 1, CD274 molecule, EGFR, ERBB, ERBB1, Epidermal growth factor receptor
Entrez ID:
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Trials
EGFR mutation + PD-L1 overexpression
LUAD
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
EGFR mutation + PD-L1 overexpression
LUAD
afatinib
Resistant: C3 – Early Trials
EGFR mutation + PD-L1 overexpression
LUAD
erlotinib
Resistant: C3 – Early Trials
EGFR mutation + PD-L1 overexpression
LUAD
gefitinib
Resistant: C3 – Early Trials
EGFR mutation + PD-L1 overexpression
NSCLC
EGFR inhibitor
Sensitive: C3 – Early Trials
EGFR mutation + PD-L1 overexpression
NSCLC
pembrolizumab
Resistant: C3 – Early Trials
EGFR mutation + PD-L1 overexpression
NSCLC
osimertinib
Resistant: C3 – Early Trials