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BIOMARKER:
EGFR N771delinsKG
i
Other names:
EGFR, ERBB, ERBB1, Epidermal growth factor receptor
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News alerts, weekly reports and conference planners
Entrez ID:
1956
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
EGFR exon 19 deletion + EGFR T790M (10)
EGFR mutation + PD-L1 overexpression (8)
MET amplification + EGFR mutation (8)
EGFR exon 19 deletion + PD-L1 overexpression (5)
EGFR mutation + MET amplification (5)
EGFR mutation + PD-L1 expression (5)
EGFR exon 19 deletion + EGFR L643V (4)
EGFR exon 19 deletion + EGFR T790M + EGFR C797S + CTNNB1 exon 3 mutation (4)
PD-L1 expression + EGFR mutation (4)
TA-MUC1 elevation + EGFR expression (4)
TNFRSF10A overexpression + EGFR mutation (4)
EGFR exon 19 deletion + EGFR G724S (3)
EGFR exon 19 deletion + NRAS Q61K (3)
EGFR exon 19 deletion + PTEN K237Cfs*17 (3)
EGFR mutation + ANKRD1 overexpression (3)
EGFR mutation + EGFR amplification (3)
EGFR mutation + MET overexpression (3)
EGFR wild-type + ALK wild-type + PD-L1 expression (3)
MET overexpression + EGFR mutation (3)
AXL expression + EGFR mutation (2)
EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)
EGFR L858R + EGFR exon 19 deletion (2)
EGFR L858R + PD-L1 overexpression (2)
EGFR L858R + VOPP1-EGFR fusion + EGFR T790M (2)
EGFR exon 19 deletion + MET amplification (2)
EGFR exon 19 deletion + EGFR K754E (2)
EGFR exon 19 deletion + EGFR L861Q + EGFR G873E (2)
EGFR exon 19 deletion + KRAS mutation (2)
EGFR exon 19 deletion + PD-L1 expression (2)
EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)
EGFR exon 20 insertion + EGFR amplification (2)
EGFR mutation + BCL2L11 deletion (2)
EGFR mutation + CDCA3 underexpression (2)
EGFR mutation + PTEN deletion (2)
EGFR mutation + RET fusion (2)
EGFR mutation + YAP1 overexpression (2)
EGFR mutation + YES1 overexpression (2)
EGFR-SEPTIN14 fusion + EGFR amplification (2)
EGFR exon 19 deletion + MET Amplification + MET D1228V (2)
EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)
ERBB3 mutation + TMB-H (2)
HER-2 amplification + EGFR-ZNF880 fusion + EGFR E114K (2)
PD-L1 overexpression + EGFR mutation (2)
TMB-H + EGFR exon 19 deletion (2)
TMB-H + EGFR mutation (2)
ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)
APC V2194fs + EGFR amplification + EGFR-SEPTIN14 fusion (1)
APOA1 elevation + EGFR T790M (1)
ARID1A underexpression + EGFR mutation (1)
ATM expression + ATM T2333fs* + EGFR negative (1)
AXL overexpression + EGFR mutation (1)
AXL underexpression + EGFR mutation (1)
BCL2L11 deletion + EGFR T790M (1)
BRAF V600E + EGFR expression (1)
CCDC6-RET fusion + EGFR mutation (1)
CD276 underexpression + EGFR mutation (1)
CD74-NRG1 fusion + EGFR mutation + HER-2 mutation (1)
CRKL overexpression + EGFR mutation (1)
EGFR C797S + KRAS amplification + RB1 deletion (1)
EGFR C797S + MET amplification (1)
EGFR E746_A750del + KRAS amplification (1)
EGFR G719A + EGFR S768I + PD-L1 overexpression (1)
EGFR G719A + PD-L1 overexpression (1)
EGFR G719D + EGFR L861Q + CUX1-MET fusion (1)
EGFR L747P + PD-L1 overexpression (1)
EGFR L747_A750delinsP + MET D1228H + MET D1228N + MET D1228Y + MET Y1230H + MET amplification (1)
EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)
EGFR L858R + KDR overexpression + VEGFC overexpression (1)
EGFR L858R + KRAS amplification + RB1 deletion (1)
EGFR L858R + MET amplification (1)
EGFR L858R + MET overexpression (1)
EGFR L858R + MET positive (1)
EGFR L858R + PD-L1 expression (1)
EGFR L858R + PD-L1 underexpression (1)
EGFR L858R + ROS1 fusion (1)
EGFR L858R + ROS1-ADGRG6 fusion (1)
EGFR L858R + TMB-H (1)
EGFR L858R + VEGFA-L (1)
EGFR P719A + PD-L1 overexpression (1)
EGFR T263P + EGFR L858R + MET amplification (1)
EGFR T790M + HER-2 amplification (1)
EGFR T790M + KRAS amplification + RB1 deletion (1)
EGFR T790M + MET amplification (1)
EGFR T790M + MET positive (1)
EGFR T790M + MYC amplification (1)
EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)
EGFR T790M + TMB-H (1)
EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)
EGFR exon 19 deletion + ALK amplification (1)
EGFR exon 19 deletion + BRAF G464A (1)
EGFR exon 19 deletion + CCND1 overexpression (1)
EGFR exon 19 deletion + EGFR L747S (1)
EGFR exon 19 deletion + EGFR S768I (1)
EGFR exon 19 deletion + EGFR T790M + EGFR C797S + HER-2 amplification (1)
EGFR exon 19 deletion + EGFR T790M + PD-L1 expression (1)
EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)
EGFR exon 19 deletion + LMNA-NTRK1 fusion + EGFR T790M (1)
EGFR exon 19 deletion + MET positive (1)
EGFR exon 19 deletion + MET amplification (1)
EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y (1)
EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y + MET Y1230C (1)
EGFR exon 19 deletion + PD-L1 underexpression (1)
EGFR exon 19 deletion + PTEN deletion + PIK3CA overexpression (1)
EGFR exon 19 deletion + RBM10 S167* (1)
EGFR exon 19 deletion + STRN-ALK fusion (1)
EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)
EGFR exon 19 deletion + TP53 mutation + MET amplification (1)
EGFR exon 19 deletion + VEGFA-L (1)
EGFR exon 20 insertion + PD-L1 overexpression (1)
EGFR exon 20 insertion + TP53 mutation (1)
EGFR expression + KRAS G12C (1)
EGFR expression + TP53 mutation (1)
EGFR fusion + PD-L1 overexpression (1)
EGFR mutation + ALK negative + TMB-H (1)
EGFR mutation + BCL2L11 overexpression (1)
EGFR mutation + BRCA1 overexpression (1)
EGFR mutation + BRCA1 underexpression (1)
EGFR mutation + CCND1 expression + CDKN2A deletion (1)
EGFR mutation + CD73 overexpression (1)
EGFR mutation + Chr 14q31.1-q31.3 (1)
EGFR mutation + Chr 1p13.3-p13.1 (1)
EGFR mutation + EGFR amplification + MET amplification + MTAP deletion (1)
EGFR mutation + ER positive (1)
EGFR mutation + LANCL2 overexpression (1)
EGFR mutation + LINC00460 overexpression (1)
EGFR mutation + MET amplification + EGFR amplification (1)
EGFR mutation + MET amplification + TP53 mutation (1)
EGFR mutation + MET overexpression + MET amplification (1)
EGFR mutation + MET-CEP7 fusion (1)
EGFR mutation + PD-L1 elevation (1)
EGFR mutation + PD-L1 expression + TP53 mutation (1)
EGFR mutation + PD-L1 negative (1)
EGFR mutation + RBBP8 underexpression (1)
EGFR mutation + ROMO1 overexpression (1)
EGFR mutation + RPS6KB1 amplification (1)
EGFR mutation + S100A9 overexpression (1)
EGFR mutation + SYK overexpression (1)
EGFR mutation + TP53 expression (1)
EGFR mutation + TSLP underexpression (1)
EGFR mutation + TTF1 negative (1)
EGFR mutation + WNT5A expression (1)
EGFR negative + ALK negative + PD-L1 expression (1)
EGFR negative + S100A8 elevation (1)
EGFR negative + S100A9 elevation (1)
EGFR negative + SAA1 elevation (1)
EGFR negative + SAA2 elevation (1)
EGFR overexpression + BRAF V600E (1)
EGFR overexpression + BRAF mutation (1)
EGFR overexpression + KRAS 13D (1)
EGFR overexpression + KRAS mutation (1)
EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)
EGFR wild-type + Chr 11p11.11-q12.1 (1)
EGFR wild-type + Chr 7q31.1-q31.31 (1)
EGFR wild-type + Chr 9q21.31-q22.2 (1)
EGFR wild-type + MET amplification (1)
EGFR wild-type + MET overexpression (1)
EGFR-SEC61G fusion + EGFR amplification (1)
EGFRvIII mutation + EGFR-SEPTIN14 fusion + EGFR amplification (1)
EPHA2 expression + EGFR mutation (1)
ERCC2 positive + SYP negative + EGFR exon 21 mutation (1)
GPRC6A-RET fusion + EGFR mutation (1)
HER-2 amplification + EGFR mutation (1)
HR negative + EGFR amplification (1)
KIF5B-RET fusion + EGFR exon 19 deletion (1)
KRAS mutation + EGFR amplification (1)
MET exon 14 mutation + EGFR wild-type (1)
MET negative + EGFR mutation (1)
MET overexpression + EGFR wild-type (1)
MET positive + EGFR mutation (1)
NOTCH2-NTRK1 fusion + EGFR L858R (1)
PD-L1 underexpression + EGFR mutation (1)
PTGS2 positive + MET positive + PBK positive + EGFR mutation (1)
RBM10 deletion + EGFR mutation (1)
RBM10 underexpression + EGFR mutation (1)
ROS1 translocation + EGFR wild-type (1)
SHTN1-RET fusion + EGFR mutation (1)
SPECC1-RET fusion + EGFR mutation (1)
STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)
TERT mutation + EGFR T790M + EGFR exon 20 insertion (1)
TLN1-RET fusion + EGFR mutation (1)
TRIM24-RET fusion + EGFR mutation (1)
TRIM33-RET fusion + EGFR mutation (1)
CALR elevation + EGFR mutation (0)
HER-2 positive + FGFR1 amplification (0)
PD-L1 underexpression + EGFR wild-type (0)
EGFR exon 19 deletion + EGFR T790M (10)
EGFR mutation + PD-L1 overexpression (8)
MET amplification + EGFR mutation (8)
EGFR exon 19 deletion + PD-L1 overexpression (5)
EGFR mutation + MET amplification (5)
EGFR mutation + PD-L1 expression (5)
EGFR exon 19 deletion + EGFR L643V (4)
EGFR exon 19 deletion + EGFR T790M + EGFR C797S + CTNNB1 exon 3 mutation (4)
PD-L1 expression + EGFR mutation (4)
TA-MUC1 elevation + EGFR expression (4)
TNFRSF10A overexpression + EGFR mutation (4)
EGFR exon 19 deletion + EGFR G724S (3)
EGFR exon 19 deletion + NRAS Q61K (3)
EGFR exon 19 deletion + PTEN K237Cfs*17 (3)
EGFR mutation + ANKRD1 overexpression (3)
EGFR mutation + EGFR amplification (3)
EGFR mutation + MET overexpression (3)
EGFR wild-type + ALK wild-type + PD-L1 expression (3)
MET overexpression + EGFR mutation (3)
AXL expression + EGFR mutation (2)
EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)
EGFR L858R + EGFR exon 19 deletion (2)
EGFR L858R + PD-L1 overexpression (2)
EGFR L858R + VOPP1-EGFR fusion + EGFR T790M (2)
EGFR exon 19 deletion + MET amplification (2)
EGFR exon 19 deletion + EGFR K754E (2)
EGFR exon 19 deletion + EGFR L861Q + EGFR G873E (2)
EGFR exon 19 deletion + KRAS mutation (2)
EGFR exon 19 deletion + PD-L1 expression (2)
EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)
EGFR exon 20 insertion + EGFR amplification (2)
EGFR mutation + BCL2L11 deletion (2)
EGFR mutation + CDCA3 underexpression (2)
EGFR mutation + PTEN deletion (2)
EGFR mutation + RET fusion (2)
EGFR mutation + YAP1 overexpression (2)
EGFR mutation + YES1 overexpression (2)
EGFR-SEPTIN14 fusion + EGFR amplification (2)
EGFR exon 19 deletion + MET Amplification + MET D1228V (2)
EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)
ERBB3 mutation + TMB-H (2)
HER-2 amplification + EGFR-ZNF880 fusion + EGFR E114K (2)
PD-L1 overexpression + EGFR mutation (2)
TMB-H + EGFR exon 19 deletion (2)
TMB-H + EGFR mutation (2)
ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)
APC V2194fs + EGFR amplification + EGFR-SEPTIN14 fusion (1)
APOA1 elevation + EGFR T790M (1)
ARID1A underexpression + EGFR mutation (1)
ATM expression + ATM T2333fs* + EGFR negative (1)
AXL overexpression + EGFR mutation (1)
AXL underexpression + EGFR mutation (1)
BCL2L11 deletion + EGFR T790M (1)
BRAF V600E + EGFR expression (1)
CCDC6-RET fusion + EGFR mutation (1)
CD276 underexpression + EGFR mutation (1)
CD74-NRG1 fusion + EGFR mutation + HER-2 mutation (1)
CRKL overexpression + EGFR mutation (1)
EGFR C797S + KRAS amplification + RB1 deletion (1)
EGFR C797S + MET amplification (1)
EGFR E746_A750del + KRAS amplification (1)
EGFR G719A + EGFR S768I + PD-L1 overexpression (1)
EGFR G719A + PD-L1 overexpression (1)
EGFR G719D + EGFR L861Q + CUX1-MET fusion (1)
EGFR L747P + PD-L1 overexpression (1)
EGFR L747_A750delinsP + MET D1228H + MET D1228N + MET D1228Y + MET Y1230H + MET amplification (1)
EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)
EGFR L858R + KDR overexpression + VEGFC overexpression (1)
EGFR L858R + KRAS amplification + RB1 deletion (1)
EGFR L858R + MET amplification (1)
EGFR L858R + MET overexpression (1)
EGFR L858R + MET positive (1)
EGFR L858R + PD-L1 expression (1)
EGFR L858R + PD-L1 underexpression (1)
EGFR L858R + ROS1 fusion (1)
EGFR L858R + ROS1-ADGRG6 fusion (1)
EGFR L858R + TMB-H (1)
EGFR L858R + VEGFA-L (1)
EGFR P719A + PD-L1 overexpression (1)
EGFR T263P + EGFR L858R + MET amplification (1)
EGFR T790M + HER-2 amplification (1)
EGFR T790M + KRAS amplification + RB1 deletion (1)
EGFR T790M + MET amplification (1)
EGFR T790M + MET positive (1)
EGFR T790M + MYC amplification (1)
EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)
EGFR T790M + TMB-H (1)
EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)
EGFR exon 19 deletion + ALK amplification (1)
EGFR exon 19 deletion + BRAF G464A (1)
EGFR exon 19 deletion + CCND1 overexpression (1)
EGFR exon 19 deletion + EGFR L747S (1)
EGFR exon 19 deletion + EGFR S768I (1)
EGFR exon 19 deletion + EGFR T790M + EGFR C797S + HER-2 amplification (1)
EGFR exon 19 deletion + EGFR T790M + PD-L1 expression (1)
EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)
EGFR exon 19 deletion + LMNA-NTRK1 fusion + EGFR T790M (1)
EGFR exon 19 deletion + MET positive (1)
EGFR exon 19 deletion + MET amplification (1)
EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y (1)
EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y + MET Y1230C (1)
EGFR exon 19 deletion + PD-L1 underexpression (1)
EGFR exon 19 deletion + PTEN deletion + PIK3CA overexpression (1)
EGFR exon 19 deletion + RBM10 S167* (1)
EGFR exon 19 deletion + STRN-ALK fusion (1)
EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)
EGFR exon 19 deletion + TP53 mutation + MET amplification (1)
EGFR exon 19 deletion + VEGFA-L (1)
EGFR exon 20 insertion + PD-L1 overexpression (1)
EGFR exon 20 insertion + TP53 mutation (1)
EGFR expression + KRAS G12C (1)
EGFR expression + TP53 mutation (1)
EGFR fusion + PD-L1 overexpression (1)
EGFR mutation + ALK negative + TMB-H (1)
EGFR mutation + BCL2L11 overexpression (1)
EGFR mutation + BRCA1 overexpression (1)
EGFR mutation + BRCA1 underexpression (1)
EGFR mutation + CCND1 expression + CDKN2A deletion (1)
EGFR mutation + CD73 overexpression (1)
EGFR mutation + Chr 14q31.1-q31.3 (1)
EGFR mutation + Chr 1p13.3-p13.1 (1)
EGFR mutation + EGFR amplification + MET amplification + MTAP deletion (1)
EGFR mutation + ER positive (1)
EGFR mutation + LANCL2 overexpression (1)
EGFR mutation + LINC00460 overexpression (1)
EGFR mutation + MET amplification + EGFR amplification (1)
EGFR mutation + MET amplification + TP53 mutation (1)
EGFR mutation + MET overexpression + MET amplification (1)
EGFR mutation + MET-CEP7 fusion (1)
EGFR mutation + PD-L1 elevation (1)
EGFR mutation + PD-L1 expression + TP53 mutation (1)
EGFR mutation + PD-L1 negative (1)
EGFR mutation + RBBP8 underexpression (1)
EGFR mutation + ROMO1 overexpression (1)
EGFR mutation + RPS6KB1 amplification (1)
EGFR mutation + S100A9 overexpression (1)
EGFR mutation + SYK overexpression (1)
EGFR mutation + TP53 expression (1)
EGFR mutation + TSLP underexpression (1)
EGFR mutation + TTF1 negative (1)
EGFR mutation + WNT5A expression (1)
EGFR negative + ALK negative + PD-L1 expression (1)
EGFR negative + S100A8 elevation (1)
EGFR negative + S100A9 elevation (1)
EGFR negative + SAA1 elevation (1)
EGFR negative + SAA2 elevation (1)
EGFR overexpression + BRAF V600E (1)
EGFR overexpression + BRAF mutation (1)
EGFR overexpression + KRAS 13D (1)
EGFR overexpression + KRAS mutation (1)
EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)
EGFR wild-type + Chr 11p11.11-q12.1 (1)
EGFR wild-type + Chr 7q31.1-q31.31 (1)
EGFR wild-type + Chr 9q21.31-q22.2 (1)
EGFR wild-type + MET amplification (1)
EGFR wild-type + MET overexpression (1)
EGFR-SEC61G fusion + EGFR amplification (1)
EGFRvIII mutation + EGFR-SEPTIN14 fusion + EGFR amplification (1)
EPHA2 expression + EGFR mutation (1)
ERCC2 positive + SYP negative + EGFR exon 21 mutation (1)
GPRC6A-RET fusion + EGFR mutation (1)
HER-2 amplification + EGFR mutation (1)
HR negative + EGFR amplification (1)
KIF5B-RET fusion + EGFR exon 19 deletion (1)
KRAS mutation + EGFR amplification (1)
MET exon 14 mutation + EGFR wild-type (1)
MET negative + EGFR mutation (1)
MET overexpression + EGFR wild-type (1)
MET positive + EGFR mutation (1)
NOTCH2-NTRK1 fusion + EGFR L858R (1)
PD-L1 underexpression + EGFR mutation (1)
PTGS2 positive + MET positive + PBK positive + EGFR mutation (1)
RBM10 deletion + EGFR mutation (1)
RBM10 underexpression + EGFR mutation (1)
ROS1 translocation + EGFR wild-type (1)
SHTN1-RET fusion + EGFR mutation (1)
SPECC1-RET fusion + EGFR mutation (1)
STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)
TERT mutation + EGFR T790M + EGFR exon 20 insertion (1)
TLN1-RET fusion + EGFR mutation (1)
TRIM24-RET fusion + EGFR mutation (1)
TRIM33-RET fusion + EGFR mutation (1)
CALR elevation + EGFR mutation (0)
HER-2 positive + FGFR1 amplification (0)
PD-L1 underexpression + EGFR wild-type (0)
›
Associations
(2)
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Latest
4years
[VIRTUAL] Response to Afatinib in a Patient with NSCLC Harboring Novel EGFR Exon 20 Insertion Mutations (IASLC-WCLC 2020)
Based on this finding, afatinib might be considered as an optimal treatment for NSCLC harboring uncommon EGFR exon 20 insertion mutations. Further investigations need to be carried out.
4 years ago
Clinical
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR exon 20 insertion • EGFR exon 20 mutation • EGFR N771delinsKG
|
Gilotrif (afatinib)
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