Cymerin (ranimustine)

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Company:

Mitsubishi Tanabe

Drug class:

Alkylating agent

Related drugs:

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Discordant lymphoma characterized by the coexistence of diffuse large B-cell lymphoma in the brain and mantle cell lymphoma in the colon, rectum, and bone marrow. (PubMed, Brain Tumor Pathol)

After five cycles of R-MPV (rituximab, methotrexate, procarbazine, vincristine) therapy and three cycles of R-ESHAP (rituximab, etoposide, cytarabine, cisplatin, methylprednisolone) therapy, the patient received autologous hematopoietic stem cell transplantation using R-MEAM (rituximab, ranimustine, etoposide, cytarabine, melphalan) regimen after bridging therapy with ibrutinib. He did not relapse within 3 years of transplantation. To the best of our knowledge, this is the first case report of DLBCL and MCL coexistence.

1 month ago

Journal

IGH (Immunoglobulin Heavy Locus)

cisplatin • Imbruvica (ibrutinib) • Rituxan (rituximab) • cytarabine • etoposide IV • methotrexate • vincristine • melphalan • Matulane (procarbazine hydrochloride) • Cymerin (ranimustine)