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BIOMARKER:

TMB-H + PD-L1 negative

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News alerts, weekly reports and conference planners

Entrez ID:

Related biomarkers:

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PD-L1 elevation (15)

TMB-H + PD-L1 expression (15)

EGFR mutation + PD-L1 overexpression (8)

MSI-H/dMMR + TMB-H (8)

TMB-H + PD-L1 overexpression (7)

EGFR exon 19 deletion + PD-L1 overexpression (5)

EGFR mutation + PD-L1 expression (5)

MSI-H/dMMR + TMB-L (5)

KRAS G12C + PD-L1 overexpression (4)

KRAS mutation + PD-L1 expression (4)

MSI-H/dMMR + PD-L1 expression (4)

PD-L1 expression + EGFR mutation (4)

CD74-ROS1 F2004L + PD-L1 expression (3)

EGFR wild-type + ALK wild-type + PD-L1 expression (3)

MSI-H/dMMR + TMB-H + PD-L1 negative (3)

PD-L1 expression + TMB-H (3)

PD-L1 overexpression + KRAS mutation (3)

BRCA1 mutation + TMB-H (3)

KMT2D mutation + TMB-H (3)

MLL3 mutation + TMB-H (3)

ALK rearrangement + PD-L1 overepxression (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PD-L1 expression (2)

EGFR L858R + PD-L1 overexpression (2)

EGFR exon 19 deletion + PD-L1 expression (2)

HER-2 amplification + PD-L1 expression (2)

KRAS G12C + PD-L1 underexpression (2)

KRAS mutation + PD-L1 negative (2)

MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)

PD-1-L + PD-L1 elevation (2)

PD-L1 expression + NRAS Q61R + BRAF D594N (2)

PD-L1 expression + TMB-H + FANCA deletion (2)

PD-L1 overexpression + BRAF V600E (2)

PD-L1 overexpression + EGFR mutation (2)

PD-L1 overexpression + FGFR3 amplification (2)

PD-L1 overexpression + MET exon 14 mutation (2)

RAD51B promoter methylation + PD-L1 expression (2)

TMB-H + PD-L1 underexpression (2)

TMB-L + PD-L1 expression (2)

EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)

HER-2 expression + TMB-H (2)

LRP1B mutation + TMB-H (2)

NCOR2-NTRK1 fusion + TMB-H (2)

PAPPA2 mutation + TMB-H (2)

STK11 mutation + TMB-H (2)

TMB-H + EGFR exon 19 deletion (2)

TMB-H + EGFR mutation (2)

TMB-H + HER-2 positive (2)

TMB-H + PIK3CA mutation (2)

TMB-L + BAP1 V99M + NF2 R34 + Chr del(14q) + Chr del(19q) (2)

ALK wild-type + NT5E overexpression + PD-L1 expression (1)

ALK-EML4_V3a + PD-L1 overexpression (1)

ALK-EML4_V3b + PD-L1 overexpression (1)

BAP1 R300Gfs*6 + PD-L1 expression (1)

BAP1 deletion + TMB-L + PD-L1 expression (1)

BRAF E501Q + PD-L1 negative (1)

BRAF V600 + LDH elevation + PD-L1 negative (1)

BRAF mutation + PD-L1 overexpression (1)

BRCA1 mutation + PD-L1 expression (1)

CDKN2A mutation + PD-L1 overexpression (1)

Chr del(9p) + PD-L1 overexpression (1)

DDR + PD-L1 expression (1)

EGFR G719A + EGFR S768I + PD-L1 overexpression (1)

EGFR G719A + PD-L1 overexpression (1)

EGFR L747P + PD-L1 overexpression (1)

EGFR L858R + PD-L1 expression (1)

EGFR L858R + PD-L1 underexpression (1)

EGFR P719A + PD-L1 overexpression (1)

EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)

EGFR exon 19 deletion + EGFR T790M + PD-L1 expression (1)

EGFR exon 19 deletion + PD-L1 underexpression (1)

EGFR exon 20 insertion + PD-L1 overexpression (1)

EGFR fusion + PD-L1 overexpression (1)

EGFR mutation + PD-L1 elevation (1)

EGFR mutation + PD-L1 expression + TP53 mutation (1)

EGFR mutation + PD-L1 negative (1)

EGFR negative + ALK negative + PD-L1 expression (1)

EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)

FGFR mutation + PD-L1 expression (1)

HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)

HLA-A*02 + PD-L1 expression (1)

HLA-A*02:01 + PD-L1 expression (1)

HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)

KEAP1 mutation + TMB-H + PD-L1 overexpression (1)

KMT2C mutation + BCOR mutation + KDM5C mutation + PD-L1 expression (1)

KRAS G12C + PD-L1 expression (1)

KRAS G12C + PD-L1 underexpression + STK11 mutation (1)

KRAS mutation + PTPN11 overexpression + PD-L1 overexpression (1)

KRAS mutation + PD-L1 underexpression (1)

KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)

LDHA-L + PD-L1 expression (1)

LDHB-L + PD-L1 expression (1)

MET exon 14 mutation + MET amplification + PD-L1 overexpression (1)

MGAM mutation + PD-L1 overexpression (1)

PAPPA2 mutation + PD-L1 expression (1)

PD-L1 amplification + CD3D overexpression (1)

PD-L1 amplification + HLA-DRA overexpression (1)

PD-L1 amplification + LAG3 overexpression (1)

PD-L1 amplification + PD-L2 amplification + TMB-H (1)

PD-L1 deletion + STK11 mutation (1)

PD-L1 elevation + CXCL10 elevation + TNFA elevation (1)

PD-L1 expression + BRAF negative (1)

PD-L1 expression + JAK2 mutation (1)

PD-L1 expression + KMT2D mutation (1)

PD-L1 expression + MSI-H/dMMR (1)

PD-L1 expression + MSI-L/dMMR (1)

PD-L1 expression + PIK3CA mutation (1)

PD-L1 expression + STK11 mutation (1)

PD-L1 expression + STK11 mutation + JAK2 mutation (1)

PD-L1 expression + T-cell gene signature (1)

PD-L1 negative + KRAS G12C (1)

PD-L1 negative + TMB-L (1)

PD-L1 negative + TMB-L + STING overexpression (1)

PD-L1 overexpression + HER-2 exon 20 insertion (1)

PD-L1 overexpression + KRAS G12C + TP53 mutation (1)

PD-L1 overexpression + RET-CCDC6 fusion (1)

PD-L1 overexpression + RET-KIF5B fusion (1)

PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)

PD-L1 overexpression + TMB-H (1)

PD-L1 overexpression + TMB-H + ARID1A F2141fs*59 (1)

PD-L1 overexpression + TMB-L (1)

PD-L1 underexpression + EGFR mutation (1)

PIK3CA R88Q + PD-L1 expression (1)

POLE mutation + PD-L1 negative + TMB-H (1)

RB1 mutation + PD-L1 expression (1)

RET amplification + TMB-H + PD-L1 expression (1)

ROS1 rearrangement + PD-L1 overexpression (1)

RYR1 mutation + PD-L1 overexpression (1)

SMARCA4 deletion + dMMR/MSI-H + PD-L1 underexpression (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

STK11 mutation + TMB-H + PD-L1 overexpression (1)

TERT positive + PD-L1 expression (1)

TMB-H + PD-L1 expression + MSI-L/dMMR (1)

TMB-H + RB1 mutation + PD-L1 underexpression (1)

TMB-L + PD-L1 underexpression (1)

TP53 mutation + MET amplification + PD-L1 overexpression (1)

TP53 mutation + PD-L1 expression (1)

TP53 mutation + PD-L1 negative (1)

TP53 mutation + TMB-H + PD-L1 overexpression (1)

TTF1 expression + NAPSA expression + PD-L1 expression + TMB-H (1)

AHNAK2 mutation + TMB-H (1)

ALK mutation + TMB-H (1)

ARID1A mutation + TMB-H (1)

ARID1B mutation + TMB-H (1)

ASPSCR1-TFE3 fusion +TMB-H (1)

BRAF mutation + TMB-H (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

BRCA1 mutation + BRCA2 mutation + TMB-H (1)

BRCA2 mutation + TMB-H (1)

BRCA2 mutation + TMB-L (1)

CD20 positive + TMB-L (1)

CD74-ROS1 fusion + TMB-H (1)

CDKN2A mutation + TMB-H (1)

EGFR L858R + TMB-H (1)

EGFR T790M + TMB-H (1)

EGFR mutation + ALK negative + TMB-H (1)

ELF3 mutation + TMB-L + MSI-L/dMMR (1)

EML4-ALK fusion + TMB-L (1)

ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)

ERBB3 R135C + TMB-H (1)

HER-2 elevation + TMB-H (1)

HER-2 elevation + TMB-L (1)

HER-2 mutation + TMB-H (1)

HLA-E overexpression + TMB-L (1)

HR positive + TMB-H (1)

HR positive + TMB-L (1)

High IFNG gene signature + TMB-H (1)

IDH1 mutation + TMB-L (1)

IDH2 mutation + TMB-L (1)

KMT2C mutation + BCOR mutation + KDM5C mutation + TMB-H (1)

KMT2C mutation + TMB-H (1)

KRAS A146 + TMB-H (1)

KRAS G12D + HER-2 amplification + TMB-H (1)

MAP2K1 mutation + TMB-H (1)

MAP2K2 mutation + TMB-H (1)

MET mutation + TMB-H (1)

MGA mutation + TMB-L (1)

MGAM mutation + TMB-H (1)

MLH1 methylation + MSI-H/dMMR + TMB-H (1)

MSI-H/dMMR + TMB-H + POLE mutation (1)

NCR3LG1 underexpression + TMB-L (1)

NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)

NPAP1 mutation + TMB-H (1)

NTRK3 mutation + TMB-H (1)

PBRM1 mutation + TMB-H (1)

PBRM1 mutation + TMB-L + MSI-L/dMMR (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

POLE E790Q + ERBB2 amplification + TMB-H (1)

POLE P286R + TMB-H (1)

POLE V1368M + ERBB3 G1271S + TNFAIP3 P714A + PRKN I69T + TSC2 G1399R + TMB-L (1)

PTCH1 1504-1G>T + TMB-H (1)

PTPN11 mutation + TMB-H (1)

PTPRD mutation + TMB-H (1)

RECQL5 mutation + TMB-H (1)

RYR1 mutation + TMB-H (1)

SMARCA4 mutation + TMB-H (1)

SMARCB1 mutation + TMB-H (1)

STK11 deletion + TMB-H (1)

TMB-H + ALK rearrangement (1)

TMB-H + CDKN2B mutation (1)

TMB-H + DDR (1)

TMB-H + KDM6A mutation (1)

TMB-H + LDH elevation (1)

TMB-H + MLL2 mutation (1)

TMB-H + MSH6 F1088fs (1)

TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)

TMB-H + TERT promoter mutation (1)

TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23 (1)

TMB-L + LDH elevation (1)

TMB-L + RB1 mutation (1)

TP53 S12F + KRAS G12D + TMB-L (1)

TP53 mutation + FANCM mutation + TMB-H (1)

TP53 mutation + LRP1B mutation + TMB-H (1)

TPR mutation + TMB-H (1)

XIRP2 mutation + TMB-H (1)

ZNF479 mutation + TMB-H (1)

ARID1A mutation + PD-L1 expression (0)

DDX3X mutation + PD-L1 overexpression (0)

LDHA-H + PD-L1 negative (0)

LDHB-H + PD-L1 negative (0)

NOTCH4 mutation + PD-L1 expression + TMB-H (0)

PD-L1 overexpression + BRAF mutation (0)

PD-L1 underexpression + ALK wild-type (0)

PD-L1 underexpression + EGFR wild-type (0)

STAT3 mutation + PD-L1 overexpression (0)

HR positive + HER-2 negative + TMB-L (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

PD-L1 elevation (15)

TMB-H + PD-L1 expression (15)

EGFR mutation + PD-L1 overexpression (8)

MSI-H/dMMR + TMB-H (8)

TMB-H + PD-L1 overexpression (7)

EGFR exon 19 deletion + PD-L1 overexpression (5)

EGFR mutation + PD-L1 expression (5)

MSI-H/dMMR + TMB-L (5)

KRAS G12C + PD-L1 overexpression (4)

KRAS mutation + PD-L1 expression (4)

MSI-H/dMMR + PD-L1 expression (4)

PD-L1 expression + EGFR mutation (4)

CD74-ROS1 F2004L + PD-L1 expression (3)

EGFR wild-type + ALK wild-type + PD-L1 expression (3)

MSI-H/dMMR + TMB-H + PD-L1 negative (3)

PD-L1 expression + TMB-H (3)

PD-L1 overexpression + KRAS mutation (3)

BRCA1 mutation + TMB-H (3)

KMT2D mutation + TMB-H (3)

MLL3 mutation + TMB-H (3)

ALK rearrangement + PD-L1 overepxression (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PD-L1 expression (2)

EGFR L858R + PD-L1 overexpression (2)

EGFR exon 19 deletion + PD-L1 expression (2)

HER-2 amplification + PD-L1 expression (2)

KRAS G12C + PD-L1 underexpression (2)

KRAS mutation + PD-L1 negative (2)

MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)

PD-1-L + PD-L1 elevation (2)

PD-L1 expression + NRAS Q61R + BRAF D594N (2)

PD-L1 expression + TMB-H + FANCA deletion (2)

PD-L1 overexpression + BRAF V600E (2)

PD-L1 overexpression + EGFR mutation (2)

PD-L1 overexpression + FGFR3 amplification (2)

PD-L1 overexpression + MET exon 14 mutation (2)

RAD51B promoter methylation + PD-L1 expression (2)

TMB-H + PD-L1 underexpression (2)

TMB-L + PD-L1 expression (2)

EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)

HER-2 expression + TMB-H (2)

LRP1B mutation + TMB-H (2)

NCOR2-NTRK1 fusion + TMB-H (2)

PAPPA2 mutation + TMB-H (2)

STK11 mutation + TMB-H (2)

TMB-H + EGFR exon 19 deletion (2)

TMB-H + EGFR mutation (2)

TMB-H + HER-2 positive (2)

TMB-H + PIK3CA mutation (2)

TMB-L + BAP1 V99M + NF2 R34 + Chr del(14q) + Chr del(19q) (2)

ALK wild-type + NT5E overexpression + PD-L1 expression (1)

ALK-EML4_V3a + PD-L1 overexpression (1)

ALK-EML4_V3b + PD-L1 overexpression (1)

BAP1 R300Gfs*6 + PD-L1 expression (1)

BAP1 deletion + TMB-L + PD-L1 expression (1)

BRAF E501Q + PD-L1 negative (1)

BRAF V600 + LDH elevation + PD-L1 negative (1)

BRAF mutation + PD-L1 overexpression (1)

BRCA1 mutation + PD-L1 expression (1)

CDKN2A mutation + PD-L1 overexpression (1)

Chr del(9p) + PD-L1 overexpression (1)

DDR + PD-L1 expression (1)

EGFR G719A + EGFR S768I + PD-L1 overexpression (1)

EGFR G719A + PD-L1 overexpression (1)

EGFR L747P + PD-L1 overexpression (1)

EGFR L858R + PD-L1 expression (1)

EGFR L858R + PD-L1 underexpression (1)

EGFR P719A + PD-L1 overexpression (1)

EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)

EGFR exon 19 deletion + EGFR T790M + PD-L1 expression (1)

EGFR exon 19 deletion + PD-L1 underexpression (1)

EGFR exon 20 insertion + PD-L1 overexpression (1)

EGFR fusion + PD-L1 overexpression (1)

EGFR mutation + PD-L1 elevation (1)

EGFR mutation + PD-L1 expression + TP53 mutation (1)

EGFR mutation + PD-L1 negative (1)

EGFR negative + ALK negative + PD-L1 expression (1)

EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)

FGFR mutation + PD-L1 expression (1)

HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)

HLA-A*02 + PD-L1 expression (1)

HLA-A*02:01 + PD-L1 expression (1)

HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)

KEAP1 mutation + TMB-H + PD-L1 overexpression (1)

KMT2C mutation + BCOR mutation + KDM5C mutation + PD-L1 expression (1)

KRAS G12C + PD-L1 expression (1)

KRAS G12C + PD-L1 underexpression + STK11 mutation (1)

KRAS mutation + PTPN11 overexpression + PD-L1 overexpression (1)

KRAS mutation + PD-L1 underexpression (1)

KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)

LDHA-L + PD-L1 expression (1)

LDHB-L + PD-L1 expression (1)

MET exon 14 mutation + MET amplification + PD-L1 overexpression (1)

MGAM mutation + PD-L1 overexpression (1)

PAPPA2 mutation + PD-L1 expression (1)

PD-L1 amplification + CD3D overexpression (1)

PD-L1 amplification + HLA-DRA overexpression (1)

PD-L1 amplification + LAG3 overexpression (1)

PD-L1 amplification + PD-L2 amplification + TMB-H (1)

PD-L1 deletion + STK11 mutation (1)

PD-L1 elevation + CXCL10 elevation + TNFA elevation (1)

PD-L1 expression + BRAF negative (1)

PD-L1 expression + JAK2 mutation (1)

PD-L1 expression + KMT2D mutation (1)

PD-L1 expression + MSI-H/dMMR (1)

PD-L1 expression + MSI-L/dMMR (1)

PD-L1 expression + PIK3CA mutation (1)

PD-L1 expression + STK11 mutation (1)

PD-L1 expression + STK11 mutation + JAK2 mutation (1)

PD-L1 expression + T-cell gene signature (1)

PD-L1 negative + KRAS G12C (1)

PD-L1 negative + TMB-L (1)

PD-L1 negative + TMB-L + STING overexpression (1)

PD-L1 overexpression + HER-2 exon 20 insertion (1)

PD-L1 overexpression + KRAS G12C + TP53 mutation (1)

PD-L1 overexpression + RET-CCDC6 fusion (1)

PD-L1 overexpression + RET-KIF5B fusion (1)

PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)

PD-L1 overexpression + TMB-H (1)

PD-L1 overexpression + TMB-H + ARID1A F2141fs*59 (1)

PD-L1 overexpression + TMB-L (1)

PD-L1 underexpression + EGFR mutation (1)

PIK3CA R88Q + PD-L1 expression (1)

POLE mutation + PD-L1 negative + TMB-H (1)

RB1 mutation + PD-L1 expression (1)

RET amplification + TMB-H + PD-L1 expression (1)

ROS1 rearrangement + PD-L1 overexpression (1)

RYR1 mutation + PD-L1 overexpression (1)

SMARCA4 deletion + dMMR/MSI-H + PD-L1 underexpression (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

STK11 mutation + TMB-H + PD-L1 overexpression (1)

TERT positive + PD-L1 expression (1)

TMB-H + PD-L1 expression + MSI-L/dMMR (1)

TMB-H + RB1 mutation + PD-L1 underexpression (1)

TMB-L + PD-L1 underexpression (1)

TP53 mutation + MET amplification + PD-L1 overexpression (1)

TP53 mutation + PD-L1 expression (1)

TP53 mutation + PD-L1 negative (1)

TP53 mutation + TMB-H + PD-L1 overexpression (1)

TTF1 expression + NAPSA expression + PD-L1 expression + TMB-H (1)

AHNAK2 mutation + TMB-H (1)

ALK mutation + TMB-H (1)

ARID1A mutation + TMB-H (1)

ARID1B mutation + TMB-H (1)

ASPSCR1-TFE3 fusion +TMB-H (1)

BRAF mutation + TMB-H (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

BRCA1 mutation + BRCA2 mutation + TMB-H (1)

BRCA2 mutation + TMB-H (1)

BRCA2 mutation + TMB-L (1)

CD20 positive + TMB-L (1)

CD74-ROS1 fusion + TMB-H (1)

CDKN2A mutation + TMB-H (1)

EGFR L858R + TMB-H (1)

EGFR T790M + TMB-H (1)

EGFR mutation + ALK negative + TMB-H (1)

ELF3 mutation + TMB-L + MSI-L/dMMR (1)

EML4-ALK fusion + TMB-L (1)

ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)

ERBB3 R135C + TMB-H (1)

HER-2 elevation + TMB-H (1)

HER-2 elevation + TMB-L (1)

HER-2 mutation + TMB-H (1)

HLA-E overexpression + TMB-L (1)

HR positive + TMB-H (1)

HR positive + TMB-L (1)

High IFNG gene signature + TMB-H (1)

IDH1 mutation + TMB-L (1)

IDH2 mutation + TMB-L (1)

KMT2C mutation + BCOR mutation + KDM5C mutation + TMB-H (1)

KMT2C mutation + TMB-H (1)

KRAS A146 + TMB-H (1)

KRAS G12D + HER-2 amplification + TMB-H (1)

MAP2K1 mutation + TMB-H (1)

MAP2K2 mutation + TMB-H (1)

MET mutation + TMB-H (1)

MGA mutation + TMB-L (1)

MGAM mutation + TMB-H (1)

MLH1 methylation + MSI-H/dMMR + TMB-H (1)

MSI-H/dMMR + TMB-H + POLE mutation (1)

NCR3LG1 underexpression + TMB-L (1)

NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)

NPAP1 mutation + TMB-H (1)

NTRK3 mutation + TMB-H (1)

PBRM1 mutation + TMB-H (1)

PBRM1 mutation + TMB-L + MSI-L/dMMR (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

POLE E790Q + ERBB2 amplification + TMB-H (1)

POLE P286R + TMB-H (1)

POLE V1368M + ERBB3 G1271S + TNFAIP3 P714A + PRKN I69T + TSC2 G1399R + TMB-L (1)

PTCH1 1504-1G>T + TMB-H (1)

PTPN11 mutation + TMB-H (1)

PTPRD mutation + TMB-H (1)

RECQL5 mutation + TMB-H (1)

RYR1 mutation + TMB-H (1)

SMARCA4 mutation + TMB-H (1)

SMARCB1 mutation + TMB-H (1)

STK11 deletion + TMB-H (1)

TMB-H + ALK rearrangement (1)

TMB-H + CDKN2B mutation (1)

TMB-H + DDR (1)

TMB-H + KDM6A mutation (1)

TMB-H + LDH elevation (1)

TMB-H + MLL2 mutation (1)

TMB-H + MSH6 F1088fs (1)

TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)

TMB-H + TERT promoter mutation (1)

TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23 (1)

TMB-L + LDH elevation (1)

TMB-L + RB1 mutation (1)

TP53 S12F + KRAS G12D + TMB-L (1)

TP53 mutation + FANCM mutation + TMB-H (1)

TP53 mutation + LRP1B mutation + TMB-H (1)

TPR mutation + TMB-H (1)

XIRP2 mutation + TMB-H (1)

ZNF479 mutation + TMB-H (1)

ARID1A mutation + PD-L1 expression (0)

DDX3X mutation + PD-L1 overexpression (0)

LDHA-H + PD-L1 negative (0)

LDHB-H + PD-L1 negative (0)

NOTCH4 mutation + PD-L1 expression + TMB-H (0)

PD-L1 overexpression + BRAF mutation (0)

PD-L1 underexpression + ALK wild-type (0)

PD-L1 underexpression + EGFR wild-type (0)

STAT3 mutation + PD-L1 overexpression (0)

HR positive + HER-2 negative + TMB-L (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

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TMB-H + PD-L1 negative	Melanoma	TMB-H + PD-L1 negative	Melanoma	atezolizumab + vemurafenib + cobimetinib Sensitive: B - Late Trials atezolizumab + vemurafenib + cobimetinib Sensitive : B	atezolizumab + vemurafenib + cobimetinib Sensitive: B - Late Trials atezolizumab + vemurafenib + cobimetinib Sensitive : B
TMB-H + PD-L1 negative	Urothelial Cancer	TMB-H + PD-L1 negative	Urothelial Cancer	tislelizumab-jsgr Sensitive: C4 – Case Studies tislelizumab-jsgr Sensitive : C4	tislelizumab-jsgr Sensitive: C4 – Case Studies tislelizumab-jsgr Sensitive : C4