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DRUG:

S63845

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Company:

HitGen, Novartis, Servier

Drug class:

MCL1 inhibitor

Related drugs:

SS18-SSX fusion	Soft Tissue Sarcoma	SS18-SSX fusion	Soft Tissue Sarcoma	venetoclax + S63845 Sensitive: C3 – Early Trials venetoclax + S63845 Sensitive : C3	venetoclax + S63845 Sensitive: C3 – Early Trials venetoclax + S63845 Sensitive : C3
BCR-ABL1 fusion	B Acute Lymphoblastic Leukemia	BCR-ABL1 fusion	B Acute Lymphoblastic Leukemia	S63845 + S55746 Sensitive: D – Preclinical S63845 + S55746 Sensitive : D	S63845 + S55746 Sensitive: D – Preclinical S63845 + S55746 Sensitive : D
BCL2L11 deletion	Diffuse Large B Cell Lymphoma	BCL2L11 deletion	Diffuse Large B Cell Lymphoma	S63845 Resistant: D – Preclinical S63845 Resistant : D	S63845 Resistant: D – Preclinical S63845 Resistant : D
BCL2 expression	Diffuse Large B Cell Lymphoma	BCL2 expression	Diffuse Large B Cell Lymphoma	venetoclax + S63845 Sensitive: D – Preclinical venetoclax + S63845 Sensitive : D	venetoclax + S63845 Sensitive: D – Preclinical venetoclax + S63845 Sensitive : D
MCL1 expression	Diffuse Large B Cell Lymphoma	MCL1 expression	Diffuse Large B Cell Lymphoma	venetoclax + S63845 Sensitive: D – Preclinical venetoclax + S63845 Sensitive : D	venetoclax + S63845 Sensitive: D – Preclinical venetoclax + S63845 Sensitive : D
MCL1 expression	Diffuse Large B Cell Lymphoma	MCL1 expression	Diffuse Large B Cell Lymphoma	S63845 Sensitive: D – Preclinical S63845 Sensitive : D	S63845 Sensitive: D – Preclinical S63845 Sensitive : D
BCL2 expression	Diffuse Large B Cell Lymphoma	BCL2 expression	Diffuse Large B Cell Lymphoma	S63845 Resistant: D – Preclinical S63845 Resistant : D	S63845 Resistant: D – Preclinical S63845 Resistant : D
MCL1 expression	Multiple Myeloma	MCL1 expression	Multiple Myeloma	S63845 Sensitive: D – Preclinical S63845 Sensitive : D	S63845 Sensitive: D – Preclinical S63845 Sensitive : D
BCL2 expression	Multiple Myeloma	BCL2 expression	Multiple Myeloma	S63845 Sensitive: D – Preclinical S63845 Sensitive : D	S63845 Sensitive: D – Preclinical S63845 Sensitive : D
ATM deletion + SF3B1 mutation	Chronic Lymphocytic Leukemia	ATM deletion + SF3B1 mutation	Chronic Lymphocytic Leukemia	S63845 Sensitive: D – Preclinical S63845 Sensitive : D	S63845 Sensitive: D – Preclinical S63845 Sensitive : D
CD34 positive	Acute Myelogenous Leukemia	CD34 positive	Acute Myelogenous Leukemia	S63845 + BMIi-1 Sensitive: D – Preclinical S63845 + BMIi-1 Sensitive : D	S63845 + BMIi-1 Sensitive: D – Preclinical S63845 + BMIi-1 Sensitive : D
CD34 positive + MN1 overexpression + MCL1 elevation	Acute Myelogenous Leukemia	CD34 positive + MN1 overexpression + MCL1 elevation	Acute Myelogenous Leukemia	S63845 + BMIi-1 Sensitive: D – Preclinical S63845 + BMIi-1 Sensitive : D	S63845 + BMIi-1 Sensitive: D – Preclinical S63845 + BMIi-1 Sensitive : D
BRAF V600E	Melanoma	BRAF V600E	Melanoma	encorafenib + S63845 Sensitive: D – Preclinical encorafenib + S63845 Sensitive : D	encorafenib + S63845 Sensitive: D – Preclinical encorafenib + S63845 Sensitive : D
BST1 positive	Acute Myelogenous Leukemia	BST1 positive	Acute Myelogenous Leukemia	S63845 Sensitive: D – Preclinical S63845 Sensitive : D	S63845 Sensitive: D – Preclinical S63845 Sensitive : D
ER positive	Estrogen Receptor Positive Breast Cancer	ER positive	Estrogen Receptor Positive Breast Cancer	S63845 + A-1331852 Sensitive: D – Preclinical S63845 + A-1331852 Sensitive : D	S63845 + A-1331852 Sensitive: D – Preclinical S63845 + A-1331852 Sensitive : D
FBXW7 underexpression	Breast Cancer	FBXW7 underexpression	Breast Cancer	JQ-1 + S63845 Sensitive: D – Preclinical JQ-1 + S63845 Sensitive : D	JQ-1 + S63845 Sensitive: D – Preclinical JQ-1 + S63845 Sensitive : D
MCL1 overexpression + HER-2 amplification	Breast Cancer	MCL1 overexpression + HER-2 amplification	Breast Cancer	S63845 Sensitive: D – Preclinical S63845 Sensitive : D	S63845 Sensitive: D – Preclinical S63845 Sensitive : D