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Association details:
| Biomarker: | ATM deletion + SF3B1 mutation |
|---|---|
| Cancer: | Chronic Lymphocytic Leukemia |
| Drug: | S63845 (MCL1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Identification of Genotype-Specific Therapeutic Vulnerabilities By Comparative Dynamic BH3 Profiling Analysis of Human and Murine CLL
Published date:
11/06/2019
Excerpt:
...transplanted with murine CLLs carrying either MDR or Sf3b1mut/Atmdel mutations. Reduced activity of the MCL1 inhibitor S63845 was observed in murine CLLs compared to human CLLs (p=0.024, Mann-Whitney U test)...
DOI:
https://doi.org/10.1182/blood-2019-127293
