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DRUG:

tapotoclax (AMG 176)

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Company:

Amgen, BeiGene

Drug class:

MCL1 inhibitor

Related drugs:

FLT3-ITD mutation	Acute Myelogenous Leukemia	FLT3-ITD mutation	Acute Myelogenous Leukemia	venetoclax + AMG 176 Sensitive: D – Preclinical venetoclax + AMG 176 Sensitive : D	venetoclax + AMG 176 Sensitive: D – Preclinical venetoclax + AMG 176 Sensitive : D
STK11 deletion + KRAS mutation	Non Small Cell Lung Cancer	STK11 deletion + KRAS mutation	Non Small Cell Lung Cancer	AMG 176 + MEK inhibitor Sensitive: D – Preclinical AMG 176 + MEK inhibitor Sensitive : D	AMG 176 + MEK inhibitor Sensitive: D – Preclinical AMG 176 + MEK inhibitor Sensitive : D
FLT3-ITD mutation	Acute Myelogenous Leukemia	FLT3-ITD mutation	Acute Myelogenous Leukemia	gilteritinib + AMG 176 Sensitive: D – Preclinical gilteritinib + AMG 176 Sensitive : D	gilteritinib + AMG 176 Sensitive: D – Preclinical gilteritinib + AMG 176 Sensitive : D