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Association details:
Biomarker:BCL2L11 deletion
Cancer:Diffuse Large B Cell Lymphoma
Drug:S63845 (MCL1 inhibitor)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: D – Preclinical
Source:
Title:

TARGETING ANTI-APOPTOTIC MCL1 PROTEIN WITH S63845 IS HIGHLY EFFECTIVE IN AGGRESSIVE B-CELL NON-HODGKIN LYMPHOMAS WITH NON-EXPRESSION OF BCL2

Published date:
06/12/2020
Excerpt:
SU-DHL-5BCL2cDNA and UPF4DBCL2cDNA clones were less sensitive to S63845 compared to controls. Similarly, SU-DHL-5BIMdel and UPF4DBIMdel cell lines were less sensitive to S63845 compared to controls...These experiments confirmed the key role of BCL2 and BIM proteins in mediating resistance to S63846.