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Association details:
| Biomarker: | MCL1 expression |
|---|---|
| Cancer: | Diffuse Large B Cell Lymphoma |
| Drug: | S63845 (MCL1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
TARGETING ANTI-APOPTOTIC MCL1 PROTEIN WITH S63845 IS HIGHLY EFFECTIVE IN AGGRESSIVE B-CELL NON-HODGKIN LYMPHOMAS WITH NON-EXPRESSION OF BCL2
Published date:
06/12/2020
Excerpt:
...while the total level of MCL1 expression did not correlate with sensitivity to S63845, the occupational status of MCL1 with proapoptotic proteins proved as an important determinant of S63845 sensitivity...co-targeting of MCL1 and BCL2 (with S63845 and venetoclax) induced additive to synergistic anti-lymphoma effect in all tested PDX models. The data represent preclinical substantiation for novel salvage therapy of this prognostically adverse group of B-NHL patients.
