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Association details:
| Biomarker: | BCL2 expression |
|---|---|
| Cancer: | Diffuse Large B Cell Lymphoma |
| Drug: | S63845 (MCL1 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
TARGETING ANTI-APOPTOTIC MCL1 PROTEIN WITH S63845 IS HIGHLY EFFECTIVE IN AGGRESSIVE B-CELL NON-HODGKIN LYMPHOMAS WITH NON-EXPRESSION OF BCL2
Published date:
06/12/2020
Excerpt:
SU-DHL-5BCL2cDNA and UPF4DBCL2cDNA clones were less sensitive to S63845 compared to controls. Similarly, SU-DHL-5BIMdel and UPF4DBIMdel cell lines were less sensitive to S63845 compared to controls...These experiments confirmed the key role of BCL2 and BIM proteins in mediating resistance to S63845.
