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BIOMARKER:
HER-2 negative
i
Other names:
ERBB2, CD340, HER-2, HER2, NEU, NGL, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
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Entrez ID:
2064
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
HER-2 mutation (89)
HER-2 exon 20 insertion (27)
HER-2 L755S (26)
HER-2 A775_G776insYVMA (10)
HER-2 S310F (10)
HER-2 V777L (10)
HER-2 L755P (7)
HER-2 S310Y (6)
HER-2 G778_P780dup (5)
HER-2 L768S (4)
HER-2 Y772_A775dup (4)
HER-2 exon 20 mutation (4)
HER-2 C634R (3)
HER-2 D769Y (3)
HER-2 I655V (3)
HER-2 K753E (3)
HER-2 L869R (3)
HER-2 V777L + EGFR L858R (3)
HER-2 V842I (3)
HER-2 G776insV_C (2)
HER-2 G776insV_G (2)
HER-2 G778_S779insCPG (2)
HER-2 G780_P781dupGSP (2)
HER-2 H878Y (2)
HER-2 L755_T759del (2)
HER-2 L866M (2)
HER-2 T798M (2)
HER-2 T862A + HER-2 L755S (2)
HER-2 V773A (2)
HER-2 V773L (2)
HER-2 V777L + PIK3CA H1047R (2)
HER-2 exon 20 YVMA insertion (2)
HER-2 exon 20G776>VC insertion (2)
ALK rearrangement + HER-2 mutation (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR T790M + HER-2 mutation (1)
ERBB3 mutation + HER-2 mutation (1)
HER-2 1899‐1G>A (1)
HER-2 755_759del (1)
HER-2 778insGSP (1)
HER-2 A1170P (1)
HER-2 A775 (1)
HER-2 D769H (1)
HER-2 E395K (1)
HER-2 G309A (1)
HER-2 G660D + HER-2 S310F (1)
HER-2 G766V (1)
HER-2 G776L (1)
HER-2 G776S (1)
HER-2 K676R (1)
HER-2 L726I (1)
HER-2 M774delinsWLV (1)
HER-2 N857S (1)
HER-2 P780-Y781insGSP (1)
HER-2 P780ins (1)
HER-2 Q57R (1)
HER-2 Q680R (1)
HER-2 R647K (1)
HER-2 R678Q (1)
HER-2 R784G (1)
HER-2 R896C (1)
HER-2 R896G (1)
HER-2 S335C (1)
HER-2 T798I (1)
HER-2 T862A (1)
HER-2 V658E (1)
HER-2 V659D (1)
HER-2 YVMA (1)
HER-2 exon 17 mutation (1)
HER-2 exon 19 mutation (1)
HER-2 exon 20 G776delinsVC (1)
HER-2 exon 23 mutation (1)
HER-2 mutation + CDK6 mutation (1)
HER-2 mutation + HER-2 T798I (1)
HER-2 mutation + TP53 wild-type (1)
HER-2 rearrangement (1)
p95HER2 mutation (1)
HER-2 negative + HR positive + PTEN mutation (0)
HER-2 negative + ER positive + ESR1 mutation (0)
HER-2 negative + HR negative + BRCA mutation (0)
HER-2 negative + HR positive + AKT1 mutation (0)
HER-2 negative + HR positive + BRCA mutation (0)
HER-2 negative + HR positive + ESR1 mutation (0)
HER-2 negative + HR positive + ESR1 mutation + PIK3CA mutation (0)
HER-2 negative + HR positive + ESR1 wild-type (0)
HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)
HER-2 negative + HR positive + PIK3CA mutation (0)
HER2 L726I (0)
HER-2 mutation (89)
HER-2 exon 20 insertion (27)
HER-2 L755S (26)
HER-2 A775_G776insYVMA (10)
HER-2 S310F (10)
HER-2 V777L (10)
HER-2 L755P (7)
HER-2 S310Y (6)
HER-2 G778_P780dup (5)
HER-2 L768S (4)
HER-2 Y772_A775dup (4)
HER-2 exon 20 mutation (4)
HER-2 C634R (3)
HER-2 D769Y (3)
HER-2 I655V (3)
HER-2 K753E (3)
HER-2 L869R (3)
HER-2 V777L + EGFR L858R (3)
HER-2 V842I (3)
HER-2 G776insV_C (2)
HER-2 G776insV_G (2)
HER-2 G778_S779insCPG (2)
HER-2 G780_P781dupGSP (2)
HER-2 H878Y (2)
HER-2 L755_T759del (2)
HER-2 L866M (2)
HER-2 T798M (2)
HER-2 T862A + HER-2 L755S (2)
HER-2 V773A (2)
HER-2 V773L (2)
HER-2 V777L + PIK3CA H1047R (2)
HER-2 exon 20 YVMA insertion (2)
HER-2 exon 20G776>VC insertion (2)
ALK rearrangement + HER-2 mutation (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR T790M + HER-2 mutation (1)
ERBB3 mutation + HER-2 mutation (1)
HER-2 1899‐1G>A (1)
HER-2 755_759del (1)
HER-2 778insGSP (1)
HER-2 A1170P (1)
HER-2 A775 (1)
HER-2 D769H (1)
HER-2 E395K (1)
HER-2 G309A (1)
HER-2 G660D + HER-2 S310F (1)
HER-2 G766V (1)
HER-2 G776L (1)
HER-2 G776S (1)
HER-2 K676R (1)
HER-2 L726I (1)
HER-2 M774delinsWLV (1)
HER-2 N857S (1)
HER-2 P780-Y781insGSP (1)
HER-2 P780ins (1)
HER-2 Q57R (1)
HER-2 Q680R (1)
HER-2 R647K (1)
HER-2 R678Q (1)
HER-2 R784G (1)
HER-2 R896C (1)
HER-2 R896G (1)
HER-2 S335C (1)
HER-2 T798I (1)
HER-2 T862A (1)
HER-2 V658E (1)
HER-2 V659D (1)
HER-2 YVMA (1)
HER-2 exon 17 mutation (1)
HER-2 exon 19 mutation (1)
HER-2 exon 20 G776delinsVC (1)
HER-2 exon 23 mutation (1)
HER-2 mutation + CDK6 mutation (1)
HER-2 mutation + HER-2 T798I (1)
HER-2 mutation + TP53 wild-type (1)
HER-2 rearrangement (1)
p95HER2 mutation (1)
HER-2 negative + HR positive + PTEN mutation (0)
HER-2 negative + ER positive + ESR1 mutation (0)
HER-2 negative + HR negative + BRCA mutation (0)
HER-2 negative + HR positive + AKT1 mutation (0)
HER-2 negative + HR positive + BRCA mutation (0)
HER-2 negative + HR positive + ESR1 mutation (0)
HER-2 negative + HR positive + ESR1 mutation + PIK3CA mutation (0)
HER-2 negative + HR positive + ESR1 wild-type (0)
HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)
HER-2 negative + HR positive + PIK3CA mutation (0)
HER2 L726I (0)
›
Related tests:
PD-L1 IHC 28-8 pharmDx (4)
PD-L1 IHC 28-8 pharmDx (4)
Associations
News
Trials
VERI cancer hierarchy
Reset Filters
HER-2 negative
Gastroesophageal Junction Adenocarcinoma
HER-2 negative
Gastroesophageal Junction Adenocarcinoma
pembrolizumab
Sensitive: A1 - Approval
pembrolizumab
Sensitive
:
A1
pembrolizumab
Sensitive: A1 - Approval
pembrolizumab
Sensitive
:
A1
HER-2 negative
Gastric Cancer
HER-2 negative
Gastric Cancer
pembrolizumab
Sensitive: A1 - Approval
pembrolizumab
Sensitive
:
A1
pembrolizumab
Sensitive: A1 - Approval
pembrolizumab
Sensitive
:
A1
HER-2 negative
Gastric Cancer
HER-2 negative
Gastric Cancer
cisplatin + capecitabine
Sensitive: A2 - Guideline
cisplatin + capecitabine
Sensitive
:
A2
cisplatin + capecitabine
Sensitive: A2 - Guideline
cisplatin + capecitabine
Sensitive
:
A2
HER-2 negative
Gastroesophageal Junction Adenocarcinoma
HER-2 negative
Gastroesophageal Junction Adenocarcinoma
cisplatin + capecitabine
Sensitive: A2 - Guideline
cisplatin + capecitabine
Sensitive
:
A2
cisplatin + capecitabine
Sensitive: A2 - Guideline
cisplatin + capecitabine
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
Sensitive: A2 - Guideline
Sensitive
:
A2
Sensitive: A2 - Guideline
Sensitive
:
A2
HER-2 negative
Gastroesophageal Junction Adenocarcinoma
HER-2 negative
Gastroesophageal Junction Adenocarcinoma
Sensitive: A2 - Guideline
Sensitive
:
A2
Sensitive: A2 - Guideline
Sensitive
:
A2
HER-2 negative
Gastroesophageal Junction Adenocarcinoma
HER-2 negative
Gastroesophageal Junction Adenocarcinoma
5-fluorouracil + oxaliplatin
Sensitive: A2 - Guideline
5-fluorouracil + oxaliplatin
Sensitive
:
A2
5-fluorouracil + oxaliplatin
Sensitive: A2 - Guideline
5-fluorouracil + oxaliplatin
Sensitive
:
A2
HER-2 negative
Gastroesophageal Junction Adenocarcinoma
HER-2 negative
Gastroesophageal Junction Adenocarcinoma
Sensitive: A2 - Guideline
Sensitive
:
A2
Sensitive: A2 - Guideline
Sensitive
:
A2
HER-2 negative
Gastric Cancer
HER-2 negative
Gastric Cancer
cisplatin + 5-fluorouracil
Sensitive: A2 - Guideline
cisplatin + 5-fluorouracil
Sensitive
:
A2
cisplatin + 5-fluorouracil
Sensitive: A2 - Guideline
cisplatin + 5-fluorouracil
Sensitive
:
A2
HER-2 negative
Gastric Cancer
HER-2 negative
Gastric Cancer
Sensitive: A2 - Guideline
Sensitive
:
A2
Sensitive: A2 - Guideline
Sensitive
:
A2
HER-2 negative
Gastric Cancer
HER-2 negative
Gastric Cancer
5-fluorouracil + oxaliplatin
Sensitive: A2 - Guideline
5-fluorouracil + oxaliplatin
Sensitive
:
A2
5-fluorouracil + oxaliplatin
Sensitive: A2 - Guideline
5-fluorouracil + oxaliplatin
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
eribulin mesylate
Sensitive: A2 - Guideline
eribulin mesylate
Sensitive
:
A2
eribulin mesylate
Sensitive: A2 - Guideline
eribulin mesylate
Sensitive
:
A2
HER-2 negative
Gastric Cancer
HER-2 negative
Gastric Cancer
nivolumab
Sensitive: A2 - Guideline
nivolumab
Sensitive
:
A2
nivolumab
Sensitive: A2 - Guideline
nivolumab
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
ribociclib
Sensitive: A2 - Guideline
ribociclib
Sensitive
:
A2
ribociclib
Sensitive: A2 - Guideline
ribociclib
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
docetaxel
Sensitive: A2 - Guideline
docetaxel
Sensitive
:
A2
docetaxel
Sensitive: A2 - Guideline
docetaxel
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
paclitaxel
Sensitive: A2 - Guideline
paclitaxel
Sensitive
:
A2
paclitaxel
Sensitive: A2 - Guideline
paclitaxel
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
bevacizumab
Sensitive: A2 - Guideline
bevacizumab
Sensitive
:
A2
bevacizumab
Sensitive: A2 - Guideline
bevacizumab
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
albumin-bound paclitaxel
Sensitive: A2 - Guideline
albumin-bound paclitaxel
Sensitive
:
A2
albumin-bound paclitaxel
Sensitive: A2 - Guideline
albumin-bound paclitaxel
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
ixabepilone
Sensitive: A2 - Guideline
ixabepilone
Sensitive
:
A2
ixabepilone
Sensitive: A2 - Guideline
ixabepilone
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
capecitabine
Sensitive: A2 - Guideline
capecitabine
Sensitive
:
A2
capecitabine
Sensitive: A2 - Guideline
capecitabine
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
gemcitabine
Sensitive: A2 - Guideline
gemcitabine
Sensitive
:
A2
gemcitabine
Sensitive: A2 - Guideline
gemcitabine
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
vinorelbine tartrate
Sensitive: A2 - Guideline
vinorelbine tartrate
Sensitive
:
A2
vinorelbine tartrate
Sensitive: A2 - Guideline
vinorelbine tartrate
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
letrozole
Sensitive: A2 - Guideline
letrozole
Sensitive
:
A2
letrozole
Sensitive: A2 - Guideline
letrozole
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
docetaxel + capecitabine
Sensitive: A2 - Guideline
docetaxel + capecitabine
Sensitive
:
A2
docetaxel + capecitabine
Sensitive: A2 - Guideline
docetaxel + capecitabine
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
tamoxifen
Sensitive: A2 - Guideline
tamoxifen
Sensitive
:
A2
tamoxifen
Sensitive: A2 - Guideline
tamoxifen
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
carboplatin + albumin-bound paclitaxel
Sensitive: A2 - Guideline
carboplatin + albumin-bound paclitaxel
Sensitive
:
A2
carboplatin + albumin-bound paclitaxel
Sensitive: A2 - Guideline
carboplatin + albumin-bound paclitaxel
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
everolimus
Sensitive: A2 - Guideline
everolimus
Sensitive
:
A2
everolimus
Sensitive: A2 - Guideline
everolimus
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
Sensitive: A2 - Guideline
Sensitive
:
A2
Sensitive: A2 - Guideline
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
fulvestrant
Sensitive: A2 - Guideline
fulvestrant
Sensitive
:
A2
fulvestrant
Sensitive: A2 - Guideline
fulvestrant
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
fulvestrant + anastrozole
Sensitive: A2 - Guideline
fulvestrant + anastrozole
Sensitive
:
A2
fulvestrant + anastrozole
Sensitive: A2 - Guideline
fulvestrant + anastrozole
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
fulvestrant + letrozole
Sensitive: A2 - Guideline
fulvestrant + letrozole
Sensitive
:
A2
fulvestrant + letrozole
Sensitive: A2 - Guideline
fulvestrant + letrozole
Sensitive
:
A2
HER-2 negative
HER2 Negative Breast Cancer
HER-2 negative
HER2 Negative Breast Cancer
palbociclib
Sensitive: A2 - Guideline
palbociclib
Sensitive
:
A2
palbociclib
Sensitive: A2 - Guideline
palbociclib
Sensitive
:
A2
^
^
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