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BIOMARKER:

FGFR2b overexpression + HER-2 negative

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Entrez ID:

Related biomarkers:

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HER-2 mutation (89)

FGFR2 mutation (30)

HER-2 exon 20 insertion (27)

HER-2 L755S (26)

HER-2 A775_G776insYVMA (10)

HER-2 S310F (10)

HER-2 V777L (10)

HER-2 L755P (7)

FGFR2 N549K (7)

FGFR2 rearrangement (7)

HER-2 S310Y (6)

HER-2 G778_P780dup (5)

HER-2 L768S (4)

HER-2 Y772_A775dup (4)

HER-2 exon 20 mutation (4)

HER-2 C634R (3)

HER-2 D769Y (3)

HER-2 I655V (3)

HER-2 K753E (3)

HER-2 L869R (3)

HER-2 V777L + EGFR L858R (3)

HER-2 V842I (3)

FGFR2 P253R (3)

HER-2 G776insV_C (2)

HER-2 G776insV_G (2)

HER-2 G778_S779insCPG (2)

HER-2 G780_P781dupGSP (2)

HER-2 H878Y (2)

HER-2 L755_T759del (2)

HER-2 L866M (2)

HER-2 T798M (2)

HER-2 T862A + HER-2 L755S (2)

HER-2 V773A (2)

HER-2 V773L (2)

HER-2 V777L + PIK3CA H1047R (2)

HER-2 exon 20 YVMA insertion (2)

HER-2 exon 20G776>VC insertion (2)

FGFR2 K310R (2)

FGFR2 translocation (2)

ALK rearrangement + HER-2 mutation (1)

EGFR L858R + TP53 R273C + HER-2 S442L (1)

EGFR T790M + HER-2 mutation (1)

ERBB3 mutation + HER-2 mutation (1)

HER-2 1899‐1G>A (1)

HER-2 755_759del (1)

HER-2 778insGSP (1)

HER-2 A1170P (1)

HER-2 D769H (1)

HER-2 E395K (1)

HER-2 G309A (1)

HER-2 G660D + HER-2 S310F (1)

HER-2 G766V (1)

HER-2 G776L (1)

HER-2 G776S (1)

HER-2 K676R (1)

HER-2 L726I (1)

HER-2 M774delinsWLV (1)

HER-2 N857S (1)

HER-2 P780-Y781insGSP (1)

HER-2 P780ins (1)

HER-2 Q680R (1)

HER-2 R647K (1)

HER-2 R678Q (1)

HER-2 R784G (1)

HER-2 R896C (1)

HER-2 R896G (1)

HER-2 S335C (1)

HER-2 T798I (1)

HER-2 T862A (1)

HER-2 V658E (1)

HER-2 V659D (1)

HER-2 exon 17 mutation (1)

HER-2 exon 19 mutation (1)

HER-2 exon 20 G776delinsVC (1)

HER-2 exon 23 mutation (1)

HER-2 mutation + CDK6 mutation (1)

HER-2 mutation + HER-2 T798I (1)

HER-2 mutation + TP53 wild-type (1)

HER-2 rearrangement (1)

p95HER2 mutation (1)

ARID1A K1238fs + FGFR2 R210Q (1)

BAP1 mutation + FGFR2 rearrangement (1)

FDFT1 rearrangement + FGFR2 rearrangement (1)

FGFR2 A391E (1)

FGFR2 B252W (1)

FGFR2 C382R (1)

FGFR2 E250G (1)

FGFR2 E565A (1)

FGFR2 E565G (1)

FGFR2 E565K (1)

FGFR2 F276C (1)

FGFR2 M540_I541insMM (1)

FGFR2 N549D (1)

FGFR2 N549H (1)

FGFR2 N549T (1)

FGFR2 N550K (1)

FGFR2 S252W (1)

FGFR2 V564F (1)

FGFR2 V564I (1)

FGFR2 V564L (1)

FGFR2 Y375C (1)

FGFR2 Y376C (1)

PIK3CA mutation + FGFR2 rearrangement (1)

PIK3CB mutation + FGFR2 rearrangement (1)

PIK3R1 mutation + FGFR2 rearrangement (1)

TP53 mutation + FGFR2 rearrangement (1)

HER-2 negative + HR positive + PTEN mutation (0)

HER-2 negative + ER positive + ESR1 mutation (0)

HER-2 negative + HR negative + BRCA mutation (0)

HER-2 negative + HR positive + AKT1 mutation (0)

HER-2 negative + HR positive + BRCA mutation (0)

HER-2 negative + HR positive + ESR1 mutation (0)

HER-2 negative + HR positive + ESR1 mutation + PIK3CA mutation (0)

HER-2 negative + HR positive + ESR1 wild-type (0)

HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)

HER-2 negative + HR positive + PIK3CA mutation (0)

FGFR2 C383R (0)

FGFR2 K660N (0)

FGFR2 W290C (0)

FGFR2 wild-type (0)

HER-2 mutation (89)

FGFR2 mutation (30)

HER-2 exon 20 insertion (27)

HER-2 L755S (26)

HER-2 A775_G776insYVMA (10)

HER-2 S310F (10)

HER-2 V777L (10)

HER-2 L755P (7)

FGFR2 N549K (7)

FGFR2 rearrangement (7)

HER-2 S310Y (6)

HER-2 G778_P780dup (5)

HER-2 L768S (4)

HER-2 Y772_A775dup (4)

HER-2 exon 20 mutation (4)

HER-2 C634R (3)

HER-2 D769Y (3)

HER-2 I655V (3)

HER-2 K753E (3)

HER-2 L869R (3)

HER-2 V777L + EGFR L858R (3)

HER-2 V842I (3)

FGFR2 P253R (3)

HER-2 G776insV_C (2)

HER-2 G776insV_G (2)

HER-2 G778_S779insCPG (2)

HER-2 G780_P781dupGSP (2)

HER-2 H878Y (2)

HER-2 L755_T759del (2)

HER-2 L866M (2)

HER-2 T798M (2)

HER-2 T862A + HER-2 L755S (2)

HER-2 V773A (2)

HER-2 V773L (2)

HER-2 V777L + PIK3CA H1047R (2)

HER-2 exon 20 YVMA insertion (2)

HER-2 exon 20G776>VC insertion (2)

FGFR2 K310R (2)

FGFR2 translocation (2)

ALK rearrangement + HER-2 mutation (1)

EGFR L858R + TP53 R273C + HER-2 S442L (1)

EGFR T790M + HER-2 mutation (1)

ERBB3 mutation + HER-2 mutation (1)

HER-2 1899‐1G>A (1)

HER-2 755_759del (1)

HER-2 778insGSP (1)

HER-2 A1170P (1)

HER-2 D769H (1)

HER-2 E395K (1)

HER-2 G309A (1)

HER-2 G660D + HER-2 S310F (1)

HER-2 G766V (1)

HER-2 G776L (1)

HER-2 G776S (1)

HER-2 K676R (1)

HER-2 L726I (1)

HER-2 M774delinsWLV (1)

HER-2 N857S (1)

HER-2 P780-Y781insGSP (1)

HER-2 P780ins (1)

HER-2 Q680R (1)

HER-2 R647K (1)

HER-2 R678Q (1)

HER-2 R784G (1)

HER-2 R896C (1)

HER-2 R896G (1)

HER-2 S335C (1)

HER-2 T798I (1)

HER-2 T862A (1)

HER-2 V658E (1)

HER-2 V659D (1)

HER-2 exon 17 mutation (1)

HER-2 exon 19 mutation (1)

HER-2 exon 20 G776delinsVC (1)

HER-2 exon 23 mutation (1)

HER-2 mutation + CDK6 mutation (1)

HER-2 mutation + HER-2 T798I (1)

HER-2 mutation + TP53 wild-type (1)

HER-2 rearrangement (1)

p95HER2 mutation (1)

ARID1A K1238fs + FGFR2 R210Q (1)

BAP1 mutation + FGFR2 rearrangement (1)

FDFT1 rearrangement + FGFR2 rearrangement (1)

FGFR2 A391E (1)

FGFR2 B252W (1)

FGFR2 C382R (1)

FGFR2 E250G (1)

FGFR2 E565A (1)

FGFR2 E565G (1)

FGFR2 E565K (1)

FGFR2 F276C (1)

FGFR2 M540_I541insMM (1)

FGFR2 N549D (1)

FGFR2 N549H (1)

FGFR2 N549T (1)

FGFR2 N550K (1)

FGFR2 S252W (1)

FGFR2 V564F (1)

FGFR2 V564I (1)

FGFR2 V564L (1)

FGFR2 Y375C (1)

FGFR2 Y376C (1)

PIK3CA mutation + FGFR2 rearrangement (1)

PIK3CB mutation + FGFR2 rearrangement (1)

PIK3R1 mutation + FGFR2 rearrangement (1)

TP53 mutation + FGFR2 rearrangement (1)

HER-2 negative + HR positive + PTEN mutation (0)

HER-2 negative + ER positive + ESR1 mutation (0)

HER-2 negative + HR negative + BRCA mutation (0)

HER-2 negative + HR positive + AKT1 mutation (0)

HER-2 negative + HR positive + BRCA mutation (0)

HER-2 negative + HR positive + ESR1 mutation (0)

HER-2 negative + HR positive + ESR1 mutation + PIK3CA mutation (0)

HER-2 negative + HR positive + ESR1 wild-type (0)

HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)

HER-2 negative + HR positive + PIK3CA mutation (0)

FGFR2 C383R (0)

FGFR2 K660N (0)

FGFR2 W290C (0)

FGFR2 wild-type (0)

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FGFR2b overexpression + HER-2 negative	Gastric Cancer	FGFR2b overexpression + HER-2 negative	Gastric Cancer	AMG 552 Sensitive: B - Late Trials AMG 552 Sensitive : B	AMG 552 Sensitive: B - Late Trials AMG 552 Sensitive : B
FGFR2b overexpression + HER-2 negative	Gastroesophageal Junction Adenocarcinoma	FGFR2b overexpression + HER-2 negative	Gastroesophageal Junction Adenocarcinoma	AMG 552 Sensitive: B - Late Trials AMG 552 Sensitive : B	AMG 552 Sensitive: B - Late Trials AMG 552 Sensitive : B