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BIOMARKER:
EGFR T790M
i
Other names:
EGFR, ERBB, ERBB1, Epidermal growth factor receptor
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Entrez ID:
1956
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
EGFR expression (46)
EGFR overexpression (34)
EGFR positive (8)
EGFR negative (6)
EGFR negative + ALK negative (4)
EGFR expression + ALK positive (3)
EGFRVIII expression + PTEN expression (3)
EGFRvIII expression (3)
EGFR expression + MET expression (2)
EGFR overexpression + HER-2 overexpression (2)
MMP17 expression + EGFR expression + RB1 expression (2)
MUC1 expression + EGFR expression (2)
TROP2 expression + EGFR expression (2)
EGFR expression + HER-2 expression (1)
EGFR underexpression (1)
EGFRVIII overexpression (1)
EPHA2 overexpression + EGFR overexpression (1)
GPC3 positive + EGFR expression (1)
DRD2 expression + EGFR overexpression (0)
YAP1 overexpression + EGFR overexpression (0)
EGFR expression (46)
EGFR overexpression (34)
EGFR positive (8)
EGFR negative (6)
EGFR negative + ALK negative (4)
EGFR expression + ALK positive (3)
EGFRVIII expression + PTEN expression (3)
EGFRvIII expression (3)
EGFR expression + MET expression (2)
EGFR overexpression + HER-2 overexpression (2)
MMP17 expression + EGFR expression + RB1 expression (2)
MUC1 expression + EGFR expression (2)
TROP2 expression + EGFR expression (2)
EGFR expression + HER-2 expression (1)
EGFR underexpression (1)
EGFRVIII overexpression (1)
EPHA2 overexpression + EGFR overexpression (1)
GPC3 positive + EGFR expression (1)
DRD2 expression + EGFR overexpression (0)
YAP1 overexpression + EGFR overexpression (0)
›
Related tests:
FoundationOne® CDx (110)
Guardant360® CDx (54)
cobas® EGFR Mutation Test v2 (13)
Target Selector™ EGFR Mutation Assay
therascreen® EGFR Plus RGQ PCR Kit
FoundationOne® CDx (110)
Guardant360® CDx (54)
cobas® EGFR Mutation Test v2 (13)
Target Selector™ EGFR Mutation Assay
therascreen® EGFR Plus RGQ PCR Kit
Associations
News
Trials
VERI cancer hierarchy
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EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
osimertinib
Sensitive: A1 - Approval
osimertinib
Sensitive
:
A1
osimertinib
Sensitive: A1 - Approval
osimertinib
Sensitive
:
A1
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
lazertinib
Sensitive: A1 - Approval
lazertinib
Sensitive
:
A1
lazertinib
Sensitive: A1 - Approval
lazertinib
Sensitive
:
A1
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
aumolertinib
Sensitive: A1 - Approval
aumolertinib
Sensitive
:
A1
aumolertinib
Sensitive: A1 - Approval
aumolertinib
Sensitive
:
A1
EGFR T790M
Lung Non-Squamous Non-Small Cell Cancer
EGFR T790M
Lung Non-Squamous Non-Small Cell Cancer
osimertinib
Sensitive: A2 - Guideline
osimertinib
Sensitive
:
A2
osimertinib
Sensitive: A2 - Guideline
osimertinib
Sensitive
:
A2
EGFR T790M
Lung Adenocarcinoma
EGFR T790M
Lung Adenocarcinoma
erlotinib
Sensitive: B - Late Trials
erlotinib
Sensitive
:
B
erlotinib
Sensitive: B - Late Trials
erlotinib
Sensitive
:
B
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
erlotinib + ramucirumab
Sensitive: B - Late Trials
erlotinib + ramucirumab
Sensitive
:
B
erlotinib + ramucirumab
Sensitive: B - Late Trials
erlotinib + ramucirumab
Sensitive
:
B
EGFR T790M
Lung Adenocarcinoma
EGFR T790M
Lung Adenocarcinoma
gefitinib
Sensitive: B - Late Trials
gefitinib
Sensitive
:
B
gefitinib
Sensitive: B - Late Trials
gefitinib
Sensitive
:
B
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
bevacizumab
Sensitive: B - Late Trials
bevacizumab
Sensitive
:
B
bevacizumab
Sensitive: B - Late Trials
bevacizumab
Sensitive
:
B
EGFR T790M
Lung Adenocarcinoma
EGFR T790M
Lung Adenocarcinoma
osimertinib
Resistant: C1 - Off-label
osimertinib
Resistant
:
C1
osimertinib
Resistant: C1 - Off-label
osimertinib
Resistant
:
C1
EGFR T790M
Lung Cancer
EGFR T790M
Lung Cancer
osimertinib
Sensitive: C1 - Off-label
osimertinib
Sensitive
:
C1
osimertinib
Sensitive: C1 - Off-label
osimertinib
Sensitive
:
C1
EGFR T790M
Small Cell Lung Cancer
EGFR T790M
Small Cell Lung Cancer
osimertinib
Sensitive: C1 - Off-label
osimertinib
Sensitive
:
C1
osimertinib
Sensitive: C1 - Off-label
osimertinib
Sensitive
:
C1
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
bevacizumab + osimertinib
Sensitive: C2 – Inclusion Criteria
bevacizumab + osimertinib
Sensitive
:
C2
bevacizumab + osimertinib
Sensitive: C2 – Inclusion Criteria
bevacizumab + osimertinib
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
rociletinib
Sensitive: C2 – Inclusion Criteria
rociletinib
Sensitive
:
C2
rociletinib
Sensitive: C2 – Inclusion Criteria
rociletinib
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
ASP8273
Sensitive: C2 – Inclusion Criteria
ASP8273
Sensitive
:
C2
ASP8273
Sensitive: C2 – Inclusion Criteria
ASP8273
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
ASK120067
Sensitive: C2 – Inclusion Criteria
ASK120067
Sensitive
:
C2
ASK120067
Sensitive: C2 – Inclusion Criteria
ASK120067
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
osimertinib + ramucirumab
Sensitive: C2 – Inclusion Criteria
osimertinib + ramucirumab
Sensitive
:
C2
osimertinib + ramucirumab
Sensitive: C2 – Inclusion Criteria
osimertinib + ramucirumab
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
olmutinib
Sensitive: C2 – Inclusion Criteria
olmutinib
Sensitive
:
C2
olmutinib
Sensitive: C2 – Inclusion Criteria
olmutinib
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
osimertinib + ABT 263
Sensitive: C2 – Inclusion Criteria
osimertinib + ABT 263
Sensitive
:
C2
osimertinib + ABT 263
Sensitive: C2 – Inclusion Criteria
osimertinib + ABT 263
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
amivantamab-vmjw
Sensitive: C2 – Inclusion Criteria
amivantamab-vmjw
Sensitive
:
C2
amivantamab-vmjw
Sensitive: C2 – Inclusion Criteria
amivantamab-vmjw
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
anlotinib
Sensitive: C2 – Inclusion Criteria
anlotinib
Sensitive
:
C2
anlotinib
Sensitive: C2 – Inclusion Criteria
anlotinib
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
firmonertinib
Sensitive: C2 – Inclusion Criteria
firmonertinib
Sensitive
:
C2
firmonertinib
Sensitive: C2 – Inclusion Criteria
firmonertinib
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
abivertinib
Sensitive: C2 – Inclusion Criteria
abivertinib
Sensitive
:
C2
abivertinib
Sensitive: C2 – Inclusion Criteria
abivertinib
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
befotertinib
Sensitive: C2 – Inclusion Criteria
befotertinib
Sensitive
:
C2
befotertinib
Sensitive: C2 – Inclusion Criteria
befotertinib
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
rilertinib
Sensitive: C2 – Inclusion Criteria
rilertinib
Sensitive
:
C2
rilertinib
Sensitive: C2 – Inclusion Criteria
rilertinib
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
osimertinib + anlotinib
Sensitive: C2 – Inclusion Criteria
osimertinib + anlotinib
Sensitive
:
C2
osimertinib + anlotinib
Sensitive: C2 – Inclusion Criteria
osimertinib + anlotinib
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
AUY922
Sensitive: C2 – Inclusion Criteria
AUY922
Sensitive
:
C2
AUY922
Sensitive: C2 – Inclusion Criteria
AUY922
Sensitive
:
C2
EGFR T790M
Lung Non-Squamous Non-Small Cell Cancer
EGFR T790M
Lung Non-Squamous Non-Small Cell Cancer
PD-L1 inhibitor
Resistant: C3 – Early Trials
PD-L1 inhibitor
Resistant
:
C3
PD-L1 inhibitor
Resistant: C3 – Early Trials
PD-L1 inhibitor
Resistant
:
C3
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
EGFR inhibitor
Resistant: C3 – Early Trials
EGFR inhibitor
Resistant
:
C3
EGFR inhibitor
Resistant: C3 – Early Trials
EGFR inhibitor
Resistant
:
C3
EGFR T790M
Lung Adenocarcinoma
EGFR T790M
Lung Adenocarcinoma
bevacizumab + osimertinib
Resistant: C3 – Early Trials
bevacizumab + osimertinib
Resistant
:
C3
bevacizumab + osimertinib
Resistant: C3 – Early Trials
bevacizumab + osimertinib
Resistant
:
C3
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
EGFR T790M
Lung Adenocarcinoma
EGFR T790M
Lung Adenocarcinoma
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
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